PMID- 35320869
OWN - NLM
STAT- MEDLINE
DCOM- 20230131
LR  - 20230202
IS  - 1439-3999 (Electronic)
IS  - 0023-2165 (Linking)
VI  - 240
IP  - 1
DP  - 2023 Jan
TI  - Effects of B12 Deficiency Anemia on Radial Peripapillary and Macular Vessel 
      Density: An Optical Coherence Tomography Angiography (OCTA) Study.
PG  - 92-98
LID - 10.1055/a-1738-9941 [doi]
AB  - BACKGROUND: To evaluate the macular and optic disc vascular changes in vitamin 
      B12 deficiency anemia. METHODS: A total of 24 patients with vitamin B12 
      deficiency anemia and 24 healthy controls were involved in this study. All 
      participants were evaluated for central macular thickness (CMT), peripapillary 
      retina nerve fiber layer (RNFL) thickness, foveal avascular zone (FAZ) area, 
      macular vessel density (VD) in superficial capillary plexus (SCP) and deep 
      capillary plexus (DCP), choriocapillaris flow area, and optic disc radial 
      peripapillary capillary (RPC) VD using optic coherence tomography (OCT) and optic 
      coherence tomography angiography (OCTA). Metabolic parameters were also noted. 
      RESULTS: Temporal RNFL thickness significantly decreased in the B12 deficiency 
      anemia group (p = 0.04). Choriocapillaris flow area (p = 0.045) and macular 
      vessel density in both SCP (p = 0.022) and DCP (p = 0.018) markedly declined in 
      the study group. Optic disc RPC VD in the B12 deficiency anemia group was lower 
      in all regions compared to that of the control group, but the difference was not 
      statistically significant (p > 0.05). There were significant positive 
      correlations between choriocapillaris flow area, macular VD, vitamin B12, and 
      hemoglobin. CONCLUSION: Retinal vascular alterations were observed in B12 
      deficiency anemia, and OCTA may be beneficial in the diagnosis and follow-up of 
      ocular complications in these cases.
CI  - Thieme. All rights reserved.
FAU - Koca, Semra
AU  - Koca S
AUID- ORCID: 0000-0002-8275-1507
AD  - Department of Ophthalmology, Kayseri City Education and Research Hospital, 
      Kocasinan/Kayseri, Turkey.
FAU - Bozkurt, Erhan
AU  - Bozkurt E
AD  - Department of Internal Medicine, Afyonkarahisar Health Sciences University, 
      Afyonkarahisar, Turkey.
FAU - Dogan, Mustafa
AU  - Dogan M
AD  - Department of Ophthalmology, Afyonkarahisar Health Sciences University, 
      Afyonkarahisar, Turkey.
FAU - Yavasoglu, Filiz
AU  - Yavasoglu F
AD  - Department of Hematology, Afyonkarahisar Health Sciences University, 
      Afyonkarahisar, Turkey.
FAU - Erogul, Ozgur
AU  - Erogul O
AD  - Department of Ophthalmology, Afyonkarahisar Health Sciences University, 
      Afyonkarahisar, Turkey.
FAU - Bulut, Ayten Kocaman
AU  - Bulut AK
AD  - Department Augenheilkunde, Medizentrum Eckert MVZ GmbH, Bruchsal, Germany.
LA  - eng
PT  - Journal Article
TT  - Auswirkungen der B12-Mangelanamie auf die radiale peripapillare und makulare 
      Gefassdichte: eine optische Koharenztomografiestudie (OCTA-Studie).
DEP - 20220323
PL  - Germany
TA  - Klin Monbl Augenheilkd
JT  - Klinische Monatsblatter fur Augenheilkunde
JID - 0014133
SB  - IM
MH  - Humans
MH  - Fluorescein Angiography/methods
MH  - Retinal Vessels/diagnostic imaging/physiology
MH  - Tomography, Optical Coherence/methods
MH  - *Vitamin B 12 Deficiency/complications/diagnostic imaging
MH  - *Anemia
COIS- The authors declare that they have no conflict of interest.
EDAT- 2022/03/24 06:00
MHDA- 2023/02/01 06:00
CRDT- 2022/03/23 20:07
PHST- 2022/03/24 06:00 [pubmed]
PHST- 2023/02/01 06:00 [medline]
PHST- 2022/03/23 20:07 [entrez]
AID - 10.1055/a-1738-9941 [doi]
PST - ppublish
SO  - Klin Monbl Augenheilkd. 2023 Jan;240(1):92-98. doi: 10.1055/a-1738-9941. Epub 
      2022 Mar 23.