PMID- 35322435
OWN - NLM
STAT- MEDLINE
DCOM- 20220708
LR  - 20220930
IS  - 1745-4514 (Electronic)
IS  - 0145-8884 (Linking)
VI  - 46
IP  - 7
DP  - 2022 Jul
TI  - Chia seeds and chemical-elicited sprouts supplementation ameliorates insulin 
      resistance, dyslipidemia, and hepatic steatosis in obese rats.
PG  - e14136
LID - 10.1111/jfbc.14136 [doi]
AB  - Chia seeds (CS) and sprouts are rich in bioactive compounds. This study aimed to 
      assess the effects of germination and chemical elicitation (salicylic acid [SA]; 
      hydrogen peroxide [H(2) O(2) ]) on proximate chemical, total phenolics compounds 
      (TPC), non-extractable proanthocyanidins (NEPA), and carotenoids content of chia 
      sprouts; besides, the effects of their supplementation on obesity-associated 
      complications in rats fed with high-fat and fructose diet (HFFD) were evaluated. 
      Protein, carbohydrate, TPC, NEPA, and carotenoids content were higher in sprouts 
      than CS; elicitation enhanced TPC and carotenoids compared to non-elicited (NE) 
      sprouts. CS, NE, and elicited chia sprouts ameliorated insulin resistance and 
      dyslipidemia at the same level in HFFD-fed rats. NE and SA-chia sprouts exerted 
      the biggest reduction in hepatic triglycerides, which could be partially related 
      to inhibition of pancreatic lipase activity. In addition, SA elicitation induced 
      the greatest effect on insulin levels and corporal weight. CS and their sprouts 
      decreased obesity and its complication, mainly SA-elicited sprouts. PRACTICAL 
      APPLICATIONS: The growing epidemic of non-communicable diseases such as diabetes 
      and obesity has led to the search for prevention and treatment through lifestyle 
      changes, including the consumption of foods rich in bioactive compounds, such as 
      seeds and their sprouts. Since sprouts contain higher concentrations of bioactive 
      compounds and nutrients than seed, germination is a natural alternative to 
      produce ready-to-eat functional foods. Chemical elicitation is a strategy to 
      increase even more the bioactivity of sprouts. CS has been recognized for its 
      beneficial health effects ameliorating dyslipidemia and insulin resistance. This 
      study demonstrates that elicitation, with SA and H(2) O(2) , during germination 
      of CS, increases the nutrient and phytochemical content of sprouts, with 
      beneficial effects on body weight gain, insulin resistance, dyslipidemia, and 
      prevention of NAFLD progression in diet-induced obese rats. Therefore, chia 
      sprouts, natural and elicited, may be used as potential nutraceutical foods for 
      the prevention and treatment of obesity and its complications.
CI  - (c) 2022 Wiley Periodicals LLC.
FAU - Gomez-Velazquez, Haiku D J
AU  - Gomez-Velazquez HDJ
AUID- ORCID: 0000-0003-2621-6603
AD  - Departamento de la Tierra y de la Vida, Centro Universitario de los Lagos, 
      Universidad de Guadalajara, Lagos de Moreno, Mexico.
AD  - Research and Graduate School of Chemistry, Autonomous University of Queretaro, 
      Queretaro, Mexico.
FAU - Aparicio-Fernandez, Xochitl
AU  - Aparicio-Fernandez X
AUID- ORCID: 0000-0002-5980-085X
AD  - Departamento de la Tierra y de la Vida, Centro Universitario de los Lagos, 
      Universidad de Guadalajara, Lagos de Moreno, Mexico.
FAU - Mora, Ofelia
AU  - Mora O
AUID- ORCID: 0000-0002-7073-7740
AD  - Laboratorio de Rumiologia y Metabolismo Nutricional (RuMeN). Facultad de Estudios 
      Superiores Cuautitlan, Universidad Nacional Autonoma de Mexico, Queretaro, 
      Mexico.
FAU - Gonzalez Davalos, Maria Laura
AU  - Gonzalez Davalos ML
AUID- ORCID: 0000-0001-5581-1773
AD  - Laboratorio de Rumiologia y Metabolismo Nutricional (RuMeN). Facultad de Estudios 
      Superiores Cuautitlan, Universidad Nacional Autonoma de Mexico, Queretaro, 
      Mexico.
FAU - de Los Rios, Erika A
AU  - de Los Rios EA
AUID- ORCID: 0000-0001-9235-5199
AD  - Instituto de Neurobiologia, Universidad Nacional Autonoma de Mexico, Queretaro, 
      Mexico.
FAU - Reynoso-Camacho, Rosalia
AU  - Reynoso-Camacho R
AUID- ORCID: 0000-0002-7223-0062
AD  - Research and Graduate School of Chemistry, Autonomous University of Queretaro, 
      Queretaro, Mexico.
LA  - eng
PT  - Journal Article
DEP - 20220323
PL  - United States
TA  - J Food Biochem
JT  - Journal of food biochemistry
JID - 7706045
RN  - 0 (Phenols)
RN  - 36-88-4 (Carotenoids)
SB  - IM
MH  - Animals
MH  - Carotenoids/analysis
MH  - Diet, High-Fat
MH  - Dietary Supplements
MH  - *Dyslipidemias/drug therapy/etiology
MH  - *Fatty Liver
MH  - *Insulin Resistance
MH  - Obesity/drug therapy/metabolism
MH  - Phenols/analysis
MH  - Rats
MH  - Seeds/chemistry
OTO - NOTNLM
OT  - atherogenic dyslipidemia
OT  - chia sprouts
OT  - elicitation
OT  - hepatic steatosis
OT  - insulin resistance
OT  - polyphenol content
EDAT- 2022/03/25 06:00
MHDA- 2022/07/09 06:00
CRDT- 2022/03/24 05:40
PHST- 2022/01/19 00:00 [revised]
PHST- 2021/10/27 00:00 [received]
PHST- 2022/02/01 00:00 [accepted]
PHST- 2022/03/25 06:00 [pubmed]
PHST- 2022/07/09 06:00 [medline]
PHST- 2022/03/24 05:40 [entrez]
AID - 10.1111/jfbc.14136 [doi]
PST - ppublish
SO  - J Food Biochem. 2022 Jul;46(7):e14136. doi: 10.1111/jfbc.14136. Epub 2022 Mar 23.