PMID- 35322633
OWN - NLM
STAT- MEDLINE
DCOM- 20220401
LR  - 20231005
IS  - 2589-451X (Electronic)
IS  - 0255-2922 (Print)
IS  - 0255-2922 (Linking)
VI  - 42
IP  - 1
DP  - 2022 Feb
TI  - Effect of aqueous extract of Astragalus membranaceus on behavioral cognition of 
      rats living at high altitude.
PG  - 58-64
LID - 10.19852/j.cnki.jtcm.2022.01.005 [doi]
AB  - OBJECTIVE: To investigate the effect of aqueous extract of Astragalus 
      membranaceus on cognitive ability of rats living at high altitude. METHODS: Rats 
      were exposed to a simulated highaltitude hypobaric hypoxia chamber. The behavior 
      of rats was tested by eight-arm maze. The contents of malondialdehyde (MDA), 
      glutathione (GSH), reactive oxygen species (ROS) and activity of total superoxide 
      dismutase (T-SOD) in hippocampus were measured. The expressions of mammalian 
      target of rapamycin (mTOR) and cleaved capase-3 in hippocampus were determined by 
      reverse transcription-polymerase chain reaction and Western blot. RESULTS: The 
      behavioral cognitive ability of the hypoxic control group was significantly lower 
      than that of the normoxic control group. Under hypoxic environment, after the 
      administration of aqueous extract of Astragalus membranaceus, the behavioral 
      cognitive ability of rats was significantly improved. In hippocampal tissue, the 
      content of MDA and ROS were significantly decreased, while the content of GSH and 
      activity of T-SOD in hippocampus were significantly increased. The mRNA 
      expression of mTOR and P70S6K and the protein expression of p-mTOR were 
      significantly increased; the mRNA expression of 4E-binding protein 1 (4E-BP1) and 
      the protein expression of phosphorylated-4E-BP1 (p-4EBP1) and cleaved capase-3 
      were significantly decreased. CONCLUSION: When the rats are exposed to high 
      altitude hypoxia, the behavioral cognitive ability could be significantly 
      reduced. Aqueous extract of Astragalus membranaceus can significantly improve 
      cognitive function in rats under hypoxia. The potential mechanism is related to 
      improving oxidative stress, reducing the accumulation of free radicals and 
      metabolites, and activating mTOR signaling pathway.
FAU - Du, Xing
AU  - Du X
AD  - Gansu Institute for Drug Control, Lanzhou 730050, China.
FAU - Liu, Tian-Long
AU  - Liu TL
AD  - Department of Clinical Pharmacy, 940th Hospital of Joint Logistic Support Force 
      of PLA, Lanzhou 730050, China.
AD  - Gansu Plateau Pharmaceutical Technology Center, Lanzhou 730050, China.
FAU - Tao, Wen-di
AU  - Tao WD
AD  - Department of Clinical Pharmacy, 940th Hospital of Joint Logistic Support Force 
      of PLA, Lanzhou 730050, China.
AD  - Gansu Plateau Pharmaceutical Technology Center, Lanzhou 730050, China.
FAU - Li, Mao-Xing
AU  - Li MX
AD  - Department of Clinical Pharmacy, 940th Hospital of Joint Logistic Support Force 
      of PLA, Lanzhou 730050, China.
AD  - Gansu Plateau Pharmaceutical Technology Center, Lanzhou 730050, China.
FAU - Li, Xiao-Lin
AU  - Li XL
AD  - Department of Clinical Pharmacy, 940th Hospital of Joint Logistic Support Force 
      of PLA, Lanzhou 730050, China.
AD  - Gansu Plateau Pharmaceutical Technology Center, Lanzhou 730050, China.
FAU - Yan, Lan
AU  - Yan L
AD  - Department of Clinical Pharmacy, 940th Hospital of Joint Logistic Support Force 
      of PLA, Lanzhou 730050, China.
AD  - Gansu Plateau Pharmaceutical Technology Center, Lanzhou 730050, China.
LA  - eng
GR  - 16QNP055/Top Medical Science and Technology Youth Cultivation Program/
GR  - 20YF3FA035/Key Research and Development Program of Gansu Province/
GR  - 20yjky018/Emergency Medical Research Project of "Novel Coronavirus Pneumonia/
GR  - 31920200010/2020 Innovation Team Project of Central University/
PT  - Journal Article
PL  - China
TA  - J Tradit Chin Med
JT  - Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan
JID - 8211546
RN  - 4Y8F71G49Q (Malondialdehyde)
SB  - IM
MH  - *Altitude
MH  - Animals
MH  - *Astragalus propinquus/metabolism
MH  - Cognition
MH  - Hippocampus
MH  - Humans
MH  - Malondialdehyde/metabolism
MH  - Mammals/metabolism
MH  - Rats
PMC - PMC10164624
OTO - NOTNLM
OT  - Astragalus propinquu
OT  - Hypoxia; cognition
OT  - Oxidative stre
OT  - TOR serine-threonine kinase
EDAT- 2022/03/25 06:00
MHDA- 2022/04/02 06:00
PMCR- 2022/01/01
CRDT- 2022/03/24 05:42
PHST- 2022/03/24 05:42 [entrez]
PHST- 2022/03/25 06:00 [pubmed]
PHST- 2022/04/02 06:00 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 3245 [pii]
AID - 0255-2922-42-1-58 [pii]
AID - 10.19852/j.cnki.jtcm.2022.01.005 [doi]
PST - ppublish
SO  - J Tradit Chin Med. 2022 Feb;42(1):58-64. doi: 10.19852/j.cnki.jtcm.2022.01.005.