PMID- 35323077
OWN - NLM
STAT- MEDLINE
DCOM- 20220427
LR  - 20220609
IS  - 1522-1601 (Electronic)
IS  - 0161-7567 (Linking)
VI  - 132
IP  - 5
DP  - 2022 May 1
TI  - Acute effect of passive heat exposure on markers of cardiometabolic function in 
      adults with type 2 diabetes mellitus.
PG  - 1154-1166
LID - 10.1152/japplphysiol.00800.2021 [doi]
AB  - Heat therapy is a promising strategy to improve cardiometabolic health. This 
      study evaluated the acute physiological responses to hot water immersion in 
      adults with type 2 diabetes mellitus (T2DM). On separate days in randomized 
      order, 13 adults with T2DM [8 males/5 females, 62 +/- 12 yr, body mass index (BMI): 
      30.1 +/- 4.6 kg/m(2)] were immersed in thermoneutral (34 degrees C, 90 min) or hot (41 degrees C, 
      core temperature >/=38.5 degrees C for 60 min) water. Insulin sensitivity was quantified 
      via the minimal oral model during an oral glucose tolerance test (OGTT) performed 
      60 min after immersion. Brachial artery flow-mediated dilation (FMD) and reactive 
      hyperemia were evaluated before and 40 min after immersion. Blood samples were 
      drawn to quantify protein concentrations and mRNA levels of HSP70 and HSP90, and 
      circulating concentrations of cytokines. Relative to thermoneutral water 
      immersion, hot water immersion increased core temperature (+1.66 degrees C [+1.47, 
      +1.87], P < 0.01), heart rate (+34 beats/min [+24, +44], P < 0.01), antegrade 
      shear rate (+96 s(-1) [+57, +134], P < 0.01), and IL-6 (+1.38 pg/mL [+0.31, 
      +2.45], P = 0.01). Hot water immersion did not exert an acute change in insulin 
      sensitivity (-0.3 dL/kg/min/muU/mL [-0.9, +0.2], P = 0.18), FMD (-1.0% [-3.6, 
      +1.6], P = 0.56), peak (+0.36 mL/min/mmHg [-0.71, +1.43], P = 0.64), and total 
      (+0.11 mL/min/mmHg x min [-0.46, +0.68], P = 0.87) reactive hyperemia. There was 
      also no change in eHSP70 (P = 0.64), iHSP70 (P = 0.06), eHSP90 (P = 0.80), iHSP90 
      (P = 0.51), IL1-RA (P = 0.11), GLP-1 (P = 0.59), and NF-kappaB (P = 0.56) after hot 
      water immersion. The physiological responses elicited by hot water immersion do 
      not acutely improve markers of cardiometabolic function in adults with T2DM.NEW & 
      NOTEWORTHY Heat therapy has been shown to improve markers of cardiometabolic 
      health in preclinical and clinical studies. However, the effects of heat therapy 
      in individuals with type 2 diabetes mellitus (T2DM) remain understudied. We 
      examined the acute effect of hot water immersion on glucose tolerance, 
      flow-mediated dilation, reactive hyperemia, inflammatory markers, and heat shock 
      proteins in adults with T2DM. Hot water immersion did not acutely improve the 
      markers studied.
FAU - Behzadi, Parya
AU  - Behzadi P
AD  - Montreal Heart Institute, Montreal, Quebec, Canada.
AD  - Department of Pharmacology and Physiology, Universite de Montreal, Montreal, 
      Quebec, Canada.
FAU - Ravanelli, Nicholas
AU  - Ravanelli N
AUID- ORCID: 0000-0002-4894-9552
AD  - School of Kinesiology, Lakehead University, Thunder Bay, Ontario, Canada.
FAU - Gravel, Hugo
AU  - Gravel H
AD  - Montreal Heart Institute, Montreal, Quebec, Canada.
AD  - School of Kinesiology and Exercise Science, Universite de Montreal, Montreal, 
      Quebec, Canada.
FAU - Barry, Hadiatou
AU  - Barry H
AD  - Montreal Heart Institute, Montreal, Quebec, Canada.
AD  - Department of Pharmacology and Physiology, Universite de Montreal, Montreal, 
      Quebec, Canada.
FAU - Debray, Amelie
AU  - Debray A
AD  - Montreal Heart Institute, Montreal, Quebec, Canada.
AD  - Department of Medicine, Universite de Montreal, Montreal, Quebec, Canada.
FAU - Chaseling, Georgia K
AU  - Chaseling GK
AD  - Montreal Heart Institute, Montreal, Quebec, Canada.
AD  - Department of Pharmacology and Physiology, Universite de Montreal, Montreal, 
      Quebec, Canada.
FAU - Jacquemet, Vincent
AU  - Jacquemet V
AD  - Department of Pharmacology and Physiology, Universite de Montreal, Montreal, 
      Quebec, Canada.
FAU - Neagoe, Paul-Eduard
AU  - Neagoe PE
AD  - Montreal Heart Institute, Montreal, Quebec, Canada.
FAU - Nigam, Anil
AU  - Nigam A
AD  - Montreal Heart Institute, Montreal, Quebec, Canada.
AD  - Department of Medicine, Universite de Montreal, Montreal, Quebec, Canada.
FAU - Carpentier, Andre C
AU  - Carpentier AC
AUID- ORCID: 0000-0002-3983-8156
AD  - Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, 
      Sherbrooke, Quebec, Canada.
FAU - Sirois, Martin G
AU  - Sirois MG
AD  - Montreal Heart Institute, Montreal, Quebec, Canada.
AD  - Department of Pharmacology and Physiology, Universite de Montreal, Montreal, 
      Quebec, Canada.
FAU - Gagnon, Daniel
AU  - Gagnon D
AUID- ORCID: 0000-0001-5396-9489
AD  - Montreal Heart Institute, Montreal, Quebec, Canada.
AD  - Department of Pharmacology and Physiology, Universite de Montreal, Montreal, 
      Quebec, Canada.
AD  - School of Kinesiology and Exercise Science, Universite de Montreal, Montreal, 
      Quebec, Canada.
LA  - eng
GR  - 35775/Canada Foundation for Innovation (CFI)/
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220324
PL  - United States
TA  - J Appl Physiol (1985)
JT  - Journal of applied physiology (Bethesda, Md. : 1985)
JID - 8502536
RN  - 0 (Biomarkers)
RN  - 059QF0KO0R (Water)
SB  - IM
MH  - Aged
MH  - Biomarkers
MH  - *Diabetes Mellitus, Type 2
MH  - Female
MH  - Humans
MH  - *Hyperemia
MH  - *Insulin Resistance
MH  - Male
MH  - Middle Aged
MH  - Water
OTO - NOTNLM
OT  - heat shock proteins
OT  - inflammation
OT  - insulin
OT  - microvascular
OT  - vascular
EDAT- 2022/03/25 06:00
MHDA- 2022/04/28 06:00
CRDT- 2022/03/24 12:13
PHST- 2022/03/25 06:00 [pubmed]
PHST- 2022/04/28 06:00 [medline]
PHST- 2022/03/24 12:13 [entrez]
AID - 10.1152/japplphysiol.00800.2021 [doi]
PST - ppublish
SO  - J Appl Physiol (1985). 2022 May 1;132(5):1154-1166. doi: 
      10.1152/japplphysiol.00800.2021. Epub 2022 Mar 24.