PMID- 35324584
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230308
IS  - 2414-6366 (Electronic)
IS  - 2414-6366 (Linking)
VI  - 7
IP  - 3
DP  - 2022 Feb 28
TI  - The Use of Proton Pump Inhibitors and COVID-19: A Systematic Review and 
      Meta-Analysis.
LID - 10.3390/tropicalmed7030037 [doi]
LID - 37
AB  - COVID-19 has proved to be a serious, and consequential disease that has affected 
      millions of people globally. Previously, the adverse effects of proton pump 
      inhibitors (PPI) have been observed with increasing the risk of pneumonia and 
      COVID-19. This meta-analysis aims to address the relationship between the use of 
      PPI and the severity of COVID-19 infection. We conducted a systemic literature 
      search from PUBMED, Science Direct, and Cinahl from December 2019 to January 
      2022. Published and unpublished randomized control trials and cohort studies were 
      included. Review Manager was used for all statistical analyses. In total, 14 
      studies were included in this systemic review and meta-analysis. Outcomes of 
      interest include: (1) susceptibility of COVID-19 infection and (2) severity of 
      COVID-19 (defined as the composite of poor outcomes: ICU admission, need for 
      oxygen therapy, need for a ventilator, or death), and (3) mortality due to 
      COVID-19. PPI use was marginally associated with a nominal but statistically 
      significant increase in the risk of COVID-19 infection (OR 1.05 [1.01, 1.09]; I2 
      97%, p = 0.007). PPI use also increased the risk of the composite poor outcome 
      (OR 1.84 [1.71, 1.99]; I2 98%, p < 0.00001) and mortality (OR 1.12 [1.00, 1.25]; 
      I2 84%, p = 0.05) in patients with COVID-19.
FAU - Fatima, Kaneez
AU  - Fatima K
AD  - Department of Medicine, Dow University of Health Sciences, Karachi 75510, 
      Pakistan.
FAU - Almas, Talal
AU  - Almas T
AD  - Department of Medicine, Royal College of Surgeons in Ireland, University of 
      Medicine and Health Sciences, 15503 Dublin, Ireland.
FAU - Lakhani, Shan
AU  - Lakhani S
AD  - Department of Medicine, The Aga Khan University, Stadium Road, Karachi 74800, 
      Pakistan.
FAU - Jahangir, Arshia
AU  - Jahangir A
AD  - Department of Medicine, The Aga Khan University, Stadium Road, Karachi 74800, 
      Pakistan.
FAU - Ahmed, Abdullah
AU  - Ahmed A
AUID- ORCID: 0000-0002-9858-6155
AD  - Department of Medicine, The Aga Khan University, Stadium Road, Karachi 74800, 
      Pakistan.
FAU - Siddiqui, Ayra
AU  - Siddiqui A
AD  - Department of Medicine, The Aga Khan University, Stadium Road, Karachi 74800, 
      Pakistan.
FAU - Rahim, Aiman
AU  - Rahim A
AUID- ORCID: 0000-0002-7663-1170
AD  - Department of Medicine, Dow University of Health Sciences, Karachi 75510, 
      Pakistan.
FAU - Qureshi, Saleha Ahmed
AU  - Qureshi SA
AD  - Department of Medicine, The Aga Khan University, Stadium Road, Karachi 74800, 
      Pakistan.
FAU - Arshad, Zukhruf
AU  - Arshad Z
AD  - Department of Medicine, Dow University of Health Sciences, Karachi 75510, 
      Pakistan.
FAU - Golani, Shilpa
AU  - Golani S
AD  - Department of Medicine, The Aga Khan University, Stadium Road, Karachi 74800, 
      Pakistan.
FAU - Musheer, Adeena
AU  - Musheer A
AUID- ORCID: 0000-0003-2639-9366
AD  - Department of Medicine, Dow University of Health Sciences, Karachi 75510, 
      Pakistan.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220228
PL  - Switzerland
TA  - Trop Med Infect Dis
JT  - Tropical medicine and infectious disease
JID - 101709042
PMC - PMC8950138
OTO - NOTNLM
OT  - COVID
OT  - corona virus
OT  - infection
OT  - proton pump inhibitor
OT  - severity
OT  - susceptibility
COIS- The authors declare no conflict of interest.
EDAT- 2022/03/25 06:00
MHDA- 2022/03/25 06:01
PMCR- 2022/02/28
CRDT- 2022/03/24 17:23
PHST- 2021/12/15 00:00 [received]
PHST- 2022/02/02 00:00 [revised]
PHST- 2022/02/22 00:00 [accepted]
PHST- 2022/03/24 17:23 [entrez]
PHST- 2022/03/25 06:00 [pubmed]
PHST- 2022/03/25 06:01 [medline]
PHST- 2022/02/28 00:00 [pmc-release]
AID - tropicalmed7030037 [pii]
AID - tropicalmed-07-00037 [pii]
AID - 10.3390/tropicalmed7030037 [doi]
PST - epublish
SO  - Trop Med Infect Dis. 2022 Feb 28;7(3):37. doi: 10.3390/tropicalmed7030037.