PMID- 35324832
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220329
IS  - 2306-7381 (Electronic)
IS  - 2306-7381 (Linking)
VI  - 9
IP  - 3
DP  - 2022 Feb 25
TI  - Modulation of Hepatic Insulin and Glucagon Signaling by Nutritional Factors in 
      Broiler Chicken.
LID - 10.3390/vetsci9030103 [doi]
LID - 103
AB  - Influencing the endocrine metabolic regulation of chickens by nutritional factors 
      might provide novel possibilities for improving animal health and productivity. 
      This study was designed to evaluate the impact of dietary cereal type 
      (wheat-based (WB) vs. maize-based (MB) diets), crude protein level (normal (NP) 
      vs. lowered (LP)), and sodium (n-)butyrate (1.5 g/kg diet) supplementation (vs. 
      no butyrate) on the responsiveness of hepatic glucagon receptor (GCGR), insulin 
      receptor beta (IRbeta) and mammalian target of rapamycin (mTOR) in the phase of 
      intensive growth of chickens. Liver samples of Ross 308 broiler chickens (Gallus 
      gallus domesticus) were collected on day 21 for quantitative real-time polymerase 
      chain reaction and Western blot analyses. Hepatic GCGR and mTOR gene expressions 
      were up-regulated by WB and LP diet. GCGR and IRbeta protein level decreased in 
      groups with butyrate supplementation; however, the quantity of IRbeta and mTOR 
      protein increased in WB groups. Based on these data, the applied dietary 
      strategies may be useful tools to modulate hepatic insulin and glucagon signaling 
      of chickens in the period of intensive growth. The obtained results might 
      contribute to the better understanding of glycemic control of birds and increase 
      the opportunity of ameliorating insulin sensitivity, hence, improving the 
      production parameters and the welfare of broilers.
FAU - Petrilla, Janka
AU  - Petrilla J
AD  - Division of Biochemistry, Department of Physiology and Biochemistry, University 
      of Veterinary Medicine, 1078 Budapest, Hungary.
FAU - Matis, Gabor
AU  - Matis G
AUID- ORCID: 0000-0001-7371-9444
AD  - Division of Biochemistry, Department of Physiology and Biochemistry, University 
      of Veterinary Medicine, 1078 Budapest, Hungary.
FAU - Mackei, Mate
AU  - Mackei M
AUID- ORCID: 0000-0001-5992-6797
AD  - Division of Biochemistry, Department of Physiology and Biochemistry, University 
      of Veterinary Medicine, 1078 Budapest, Hungary.
FAU - Kulcsar, Anna
AU  - Kulcsar A
AUID- ORCID: 0000-0001-8704-0440
AD  - Division of Biochemistry, Department of Physiology and Biochemistry, University 
      of Veterinary Medicine, 1078 Budapest, Hungary.
FAU - Sebok, Csilla
AU  - Sebok C
AUID- ORCID: 0000-0003-1498-3127
AD  - Division of Biochemistry, Department of Physiology and Biochemistry, University 
      of Veterinary Medicine, 1078 Budapest, Hungary.
FAU - Papp, Marton
AU  - Papp M
AUID- ORCID: 0000-0003-4975-253X
AD  - Center for Bioinformatics, University of Veterinary Medicine, 1078 Budapest, 
      Hungary.
FAU - Galfi, Peter
AU  - Galfi P
AD  - Department of Pharmacology and Toxicology, University of Veterinary Medicine, 
      1078 Budapest, Hungary.
FAU - Febel, Hedvig
AU  - Febel H
AUID- ORCID: 0000-0002-9867-0664
AD  - Nutrition Physiology Research Group, Institute of Physiology and Nutrition, 
      Kaposvar Campus, Hungarian University of Agriculture and Life Sciences, 2053 
      Herceghalom, Hungary.
FAU - Huber, Korinna
AU  - Huber K
AD  - Department of Functional Anatomy of Livestock, Institute of Animal Science, 
      University of Hohenheim, 70593 Stuttgart, Germany.
FAU - Neogrady, Zsuzsanna
AU  - Neogrady Z
AUID- ORCID: 0000-0002-0139-1942
AD  - Division of Biochemistry, Department of Physiology and Biochemistry, University 
      of Veterinary Medicine, 1078 Budapest, Hungary.
LA  - eng
GR  - 114033/Hungarian Scientific Research Fund/
GR  - 18-3/Hungarian Ministry of Human Resources, New National Excellence Program/
GR  - EFOP-3.6.3-VEKOP-16-2017-00005/European Union, European Social Fund/
PT  - Journal Article
DEP - 20220225
PL  - Switzerland
TA  - Vet Sci
JT  - Veterinary sciences
JID - 101680127
PMC - PMC8955576
OTO - NOTNLM
OT  - butyrate
OT  - chicken
OT  - glucagon
OT  - hepatic glucagon receptor
OT  - insulin
OT  - insulin receptor beta
OT  - mammalian target of rapamycin
OT  - non-starch polysaccharides
COIS- The authors declare no conflict of interest. The funders had no role in the 
      design of the study; in the collection, analyses, or interpretation of data; in 
      the writing of the manuscript, or in the decision to publish the results.
EDAT- 2022/03/25 06:00
MHDA- 2022/03/25 06:01
PMCR- 2022/02/25
CRDT- 2022/03/24 17:24
PHST- 2022/02/07 00:00 [received]
PHST- 2022/02/17 00:00 [revised]
PHST- 2022/02/21 00:00 [accepted]
PHST- 2022/03/24 17:24 [entrez]
PHST- 2022/03/25 06:00 [pubmed]
PHST- 2022/03/25 06:01 [medline]
PHST- 2022/02/25 00:00 [pmc-release]
AID - vetsci9030103 [pii]
AID - vetsci-09-00103 [pii]
AID - 10.3390/vetsci9030103 [doi]
PST - epublish
SO  - Vet Sci. 2022 Feb 25;9(3):103. doi: 10.3390/vetsci9030103.