PMID- 35325771 OWN - NLM STAT- MEDLINE DCOM- 20220426 LR - 20220505 IS - 1873-6750 (Electronic) IS - 0160-4120 (Linking) VI - 163 DP - 2022 May TI - Per- and perfluoroalkyl substances alternatives, mixtures and liver function in adults: A community-based population study in China. PG - 107179 LID - S0160-4120(22)00105-2 [pii] LID - 10.1016/j.envint.2022.107179 [doi] AB - Experimental evidence has shown that per- and polyfluoroalkyl substances (PFAS) alternatives and mixtures may exert hepatotoxic effects in animals. However, epidemiological evidence is limited. This research aimed to explore associations of PFAS and the alternatives with liver function in a general adult population. The study participants consisted of 1,303 adults from a community-based cross-sectional investigation in Guangzhou, China, from November 2018 to August 2019. We selected 13 PFAS with detection rates > 85% in serum samples and focused on perfluorooctane-sulfonic acid (PFOS), perfluorooctanoic acid (PFOA) and their alternatives [6:2 chlorinated polyfluorinated ether sulfonate (6:2 Cl-PFESA), 8:2 Cl-PFESA, and perfluorohexanoic acid (PFHxA)] as predictors of outcome. Six liver function biomarkers (ALB, ALT, AST, GGT, ALP, and DBIL) were chosen as outcomes. We applied regression models with restricted cubic spline function to explore correlations between single PFAS and liver function and inspected the combined effect of PFAS mixtures on liver by applying Bayesian kernel machine regression (BKMR). We discovered positive associations among PFAS and liver function biomarkers except for ALP. For example, compared with the 25th percentile of PFAS concentration, the level of ALT increased by 12.36% (95% CI: 7.91%, 16.98%) for ln-6:2 Cl-PFESA, 5.59% (95% CI: 2.35%, 8.92%) for ln-8:2 Cl-PFESA, 3.56% (95% CI: -0.39%, 7.68%) for ln-PFHxA, 13.91% (95% CI: 8.93%, 19.13%) for ln-PFOA, and 14.25% (95% CI: 9.91%, 18.77%) for ln-PFOS at their 75th percentile. In addition, higher exposed serum PFAS was found to be correlated with greater odds of abnormal liver function. Analysis from BKMR models also showed an adverse association between PFAS mixtures and liver function. The combined effect of the PFAS mixture appeared to be non-interactive, in which PFOS was the main contributor to the overall effect. Our findings provide evidence of associations between PFAS alternatives, PFAS mixtures, and liver function in the general adult population. CI - Copyright (c) 2022 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Liu, Jiao-Jiao AU - Liu JJ AD - Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. FAU - Cui, Xin-Xin AU - Cui XX AD - Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. FAU - Tan, Ya-Wen AU - Tan YW AD - Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. FAU - Dong, Peng-Xin AU - Dong PX AD - Nursing College, Guangxi Medical University, Nanning 530021, China. FAU - Ou, Yan-Qiu AU - Ou YQ AD - Department of Epidemiology, Guangdong Cardiovascular Institute, WHO Collaborating Center for Research and Training in Cardiovascular Diseases, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China. FAU - Li, Qing-Qing AU - Li QQ AD - Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. FAU - Chu, Chu AU - Chu C AD - Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. FAU - Wu, Lu-Yin AU - Wu LY AD - Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. FAU - Liang, Li-Xia AU - Liang LX AD - Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. FAU - Qin, Shuang-Jian AU - Qin SJ AD - Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. FAU - Zeeshan, Mohammed AU - Zeeshan M AD - Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. FAU - Zhou, Yang AU - Zhou Y AD - Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China; State Environmental Protection Key Laboratory of Environmental Pollution Health Risk Assessment, South China Institute of Environmental Sciences, Ministry of Environmental Protection, Guangzhou 510655, China. FAU - Hu, Li-Wen AU - Hu LW AD - Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. FAU - Liu, Ru-Qing AU - Liu RQ AD - Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. FAU - Zeng, Xiao-Wen AU - Zeng XW AD - Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. Electronic address: zxw63@mail.sysu.edu.cn. FAU - Dong, Guang-Hui AU - Dong GH AD - Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. Electronic address: donggh5@mail.sysu.edu.cn. FAU - Zhao, Xiao-Miao AU - Zhao XM AD - Department of Reproductive Medicine, Department of Obstetrics and Gynecology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China. Electronic address: zhaoxmiao@163.com. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20220321 PL - Netherlands TA - Environ Int JT - Environment international JID - 7807270 RN - 0 (Alkanesulfonic Acids) RN - 0 (Environmental Pollutants) RN - 0 (Fluorocarbons) SB - IM MH - *Alkanesulfonic Acids/analysis/toxicity MH - Bayes Theorem MH - China/epidemiology MH - Cross-Sectional Studies MH - *Environmental Pollutants/analysis/toxicity MH - *Fluorocarbons/analysis/toxicity MH - Humans MH - Liver/chemistry OTO - NOTNLM OT - Liver function OT - Mixture OT - PFAS alternatives OT - PFOA OT - PFOS EDAT- 2022/03/25 06:00 MHDA- 2022/04/27 06:00 CRDT- 2022/03/24 20:13 PHST- 2021/11/08 00:00 [received] PHST- 2022/03/07 00:00 [revised] PHST- 2022/03/08 00:00 [accepted] PHST- 2022/03/25 06:00 [pubmed] PHST- 2022/04/27 06:00 [medline] PHST- 2022/03/24 20:13 [entrez] AID - S0160-4120(22)00105-2 [pii] AID - 10.1016/j.envint.2022.107179 [doi] PST - ppublish SO - Environ Int. 2022 May;163:107179. doi: 10.1016/j.envint.2022.107179. Epub 2022 Mar 21.