PMID- 35325892
OWN - NLM
STAT- MEDLINE
DCOM- 20220519
LR  - 20220626
IS  - 1423-0135 (Electronic)
IS  - 1018-1172 (Linking)
VI  - 59
IP  - 3
DP  - 2022
TI  - Association between Arteriosclerosis and Uncontrolled Blood Pressure in Patients 
      with Essential Hypertension: Cross-Sectional Observational Study Results of the 
      BEST Study.
PG  - 189-198
LID - 10.1159/000520744 [doi]
AB  - Whether arteriosclerosis can influence the hypertension control remains 
      incompletely understood. We hypothesized that higher arteriosclerosis may be 
      associated with uncontrolled hypertension. Arteriosclerosis was assessed by 
      carotid femoral artery pulse wave velocity (CF-PWV) and uncontrolled hypertension 
      (systolic blood pressure [BP] >/=130 mm Hg or diastolic BP >/=80 mm Hg). The 
      multivariable-adjusted logistic regression was used for analysis. A total of 
      1,428 patients with essential hypertension (mean age 68 years, 49.6% male) were 
      enrolled into the study from 2010 to 2017. The BP was uncontrolled in 50.7% of 
      the participants and the mean level of CF-PWV was 12.3 m/s. All the 
      cardiovascular risk factors were worse and CF-PWV was higher in patients with 
      uncontrolled hypertension (all p < 0.05). Multivariable-adjusted logistic 
      regression analysis showed that CF-PWV as a continuous variable (odd ratio [OR] 
      1.093, 95% confidence interval [CI] 1.046-1.142) was independently associated 
      with uncontrolled hypertension, after male (OR 1.511) and total cholesterol (OR 
      1.167), followed by body mass index (OR 1.092), fasting plasma glucose (OR 
      1.075), and creatinine (OR 1.010) (all p < 0.05). As a binary variable, CF-PWV 
      >12 m/s was also independently associated with uncontrolled hypertension (OR 
      1.690, 95% CI 1.320-2.164, p < 0.05). Arteriosclerosis is independently 
      associated with uncontrolled BP in patients with hypertension.
CI  - (c) 2022 S. Karger AG, Basel.
FAU - Liu, Huan
AU  - Liu H
AD  - Vascular Medicine Center, Peking University Shougang Hospital, Beijing, China, 
      sgliuhuan@163.com.
AD  - Vascular Health Research Center of Peking University Health Science Center, 
      Beijing, China, sgliuhuan@163.com.
FAU - Huang, Wei
AU  - Huang W
AD  - Vascular Medicine Center, Peking University Shougang Hospital, Beijing, China.
FAU - Liu, Jinbo
AU  - Liu J
AD  - Vascular Medicine Center, Peking University Shougang Hospital, Beijing, China.
AD  - Vascular Health Research Center of Peking University Health Science Center, 
      Beijing, China.
FAU - Zhao, Na
AU  - Zhao N
AD  - Vascular Medicine Center, Peking University Shougang Hospital, Beijing, China.
FAU - Wang, Hongyu
AU  - Wang H
AD  - Vascular Medicine Center, Peking University Shougang Hospital, Beijing, China.
AD  - Vascular Health Research Center of Peking University Health Science Center, 
      Beijing, China.
AD  - Key Laboratory of Molecular Cardiovascular Sciences, Peking University, Ministry 
      of Education, Beijing, China.
AD  - Peking University Clinical Research Institute, Beijing, China.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20220324
PL  - Switzerland
TA  - J Vasc Res
JT  - Journal of vascular research
JID - 9206092
SB  - IM
MH  - Aged
MH  - *Arteriosclerosis/complications/diagnosis/epidemiology
MH  - Blood Pressure
MH  - Essential Hypertension/complications/diagnosis/epidemiology
MH  - Female
MH  - Humans
MH  - *Hypertension/diagnosis/epidemiology
MH  - Male
MH  - Pulse Wave Analysis
MH  - Risk Factors
MH  - *Vascular Stiffness
OTO - NOTNLM
OT  - Arterial stiffness
OT  - Arteriosclerosis
OT  - Carotid femoral artery pulse wave velocity
OT  - Hypertension
EDAT- 2022/03/25 06:00
MHDA- 2022/05/20 06:00
CRDT- 2022/03/24 20:15
PHST- 2021/08/30 00:00 [received]
PHST- 2021/10/28 00:00 [accepted]
PHST- 2022/03/25 06:00 [pubmed]
PHST- 2022/05/20 06:00 [medline]
PHST- 2022/03/24 20:15 [entrez]
AID - 000520744 [pii]
AID - 10.1159/000520744 [doi]
PST - ppublish
SO  - J Vasc Res. 2022;59(3):189-198. doi: 10.1159/000520744. Epub 2022 Mar 24.