PMID- 35326098
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220329
IS  - 2076-3921 (Print)
IS  - 2076-3921 (Electronic)
IS  - 2076-3921 (Linking)
VI  - 11
IP  - 3
DP  - 2022 Feb 23
TI  - The Symbiotic Effect of a New Nutraceutical with Yeast beta-Glucan, Prebiotics, 
      Minerals, and Silybum marianum (Silymarin) for Recovering Metabolic Homeostasis 
      via Pgc-1alpha, Il-6, and Il-10 Gene Expression in a Type-2 Diabetes Obesity Model.
LID - 10.3390/antiox11030447 [doi]
LID - 447
AB  - The use of natural products and derivatives for the prevention and control of 
      non-communicable chronic diseases, such as type-2 diabetes (T2D), obesity, and 
      hepatic steatosis is a way to achieve homeostasis through different metabolic 
      pathways. Thus, male C57BL/6 mice were divided into the following groups: 
      high-fat diet (HFD) vehicle, HFD + Supplemented, HFD + Supplemented_S, and 
      isolated compounds. The vehicle and experimental formulations were administered 
      orally by gavage once a day over the four weeks of the diet (28 consecutive 
      days). We evaluated the energy homeostasis, cytokines, and mitochondrial gene 
      expression in these groups of mice. After four weeks of supplementation, only the 
      new nutraceutical group (HFD + Supplemented) experienced reduced fasting 
      glycemia, insulin, HOMA index, HOMA-beta, dyslipidemia, ectopic fat deposition, and 
      hepatic fibrosis levels. Additionally, the PPARgamma coactivator 1 alpha (Pgc-1alpha), 
      interleukin-6 (Il-6), and interleukin-10 (Il-10) gene expression were augmented, 
      while hepatic steatosis decreased and liver parenchyma was recovered. The 
      glutathione-S-transferase activity status was found to be modulated by the 
      supplement. We discovered that the new nutraceutical was able to improve insulin 
      resistance and hepatic steatosis mainly by regulating IL-6, IL-10, and Pgc-1alpha 
      gene expression.
FAU - Santamarina, Aline Boveto
AU  - Santamarina AB
AD  - Department of Biosciences, Federal University of Sao Paulo (UNIFESP), Santos 
      11015-020, SP, Brazil.
FAU - Moraes, Ruan Carlos Macedo
AU  - Moraes RCM
AUID- ORCID: 0000-0002-0178-8480
AD  - Natural Products and Derivatives Laboratory (LIM-26), Department of Surgery, 
      University of Sao Paulo Medical School, Sao Paulo 01246-903, SP, Brazil.
FAU - Nehmi Filho, Victor
AU  - Nehmi Filho V
AD  - Natural Products and Derivatives Laboratory (LIM-26), Department of Surgery, 
      University of Sao Paulo Medical School, Sao Paulo 01246-903, SP, Brazil.
AD  - Research and Development Efeom Nutrition S/A, Sao Paulo 03317-000, SP, Brazil.
FAU - Murata, Gilson Masahiro
AU  - Murata GM
AD  - Laboratory of Medical Investigation (LIM-29), Clinic Medical Department, 
      University of Sao Paulo Medical School, Sao Paulo 01246-903, SP, Brazil.
FAU - de Freitas, Jessica Alves
AU  - de Freitas JA
AUID- ORCID: 0000-0002-9457-4587
AD  - Natural Products and Derivatives Laboratory (LIM-26), Department of Surgery, 
      University of Sao Paulo Medical School, Sao Paulo 01246-903, SP, Brazil.
FAU - de Miranda, Danielle Araujo
AU  - de Miranda DA
AD  - Department of Physiology, Escola Paulista de Medicina/Universidade Federal de Sao 
      Paulo, Sao Paulo 04023-062, SP, Brazil.
FAU - Cerqueira, Anderson Romerio Azevedo
AU  - Cerqueira ARA
AUID- ORCID: 0000-0001-7057-2563
AD  - Departamento de Farmacologia, Instituto de Ciencias Biomedicas, Universidade de 
      Sao Paulo, Sao Paulo 05508-000, SP, Brazil.
FAU - Costa, Soraia Katia Pereira
AU  - Costa SKP
AUID- ORCID: 0000-0002-2574-4490
AD  - Departamento de Farmacologia, Instituto de Ciencias Biomedicas, Universidade de 
      Sao Paulo, Sao Paulo 05508-000, SP, Brazil.
FAU - Ferreira, Ana Flavia Fernandes
AU  - Ferreira AFF
AD  - Departamento de Fisiologia, Instituto de Ciencias Biomedicas, Universidade de Sao 
      Paulo, Sao Paulo 05508-000, SP, Brazil.
FAU - Britto, Luiz Roberto
AU  - Britto LR
AD  - Departamento de Fisiologia, Instituto de Ciencias Biomedicas, Universidade de Sao 
      Paulo, Sao Paulo 05508-000, SP, Brazil.
FAU - de Camargo, Juliana Alves
AU  - de Camargo JA
AD  - Laboratory of Medical Investigation (LIM-55), Urology Department, University of 
      Sao Paulo Medical School, Sao Paulo 01246-903, SP, Brazil.
FAU - Rodrigues de Oliveira, Daniela
AU  - Rodrigues de Oliveira D
AUID- ORCID: 0000-0003-0579-7234
AD  - Natural Products and Derivatives Laboratory (LIM-26), Department of Surgery, 
      University of Sao Paulo Medical School, Sao Paulo 01246-903, SP, Brazil.
AD  - Genomic Sciences and Precision Medicine Center (GSPMC), Department of Surgery, 
      Medical College of Wisconsin, Milwaukee, WI 53226, USA.
FAU - de Jesus, Flavia Neto
AU  - de Jesus FN
AD  - Department of Physiology and Pharmacology, Snyder Institute for Chronic Diseases, 
      Cumming School of Medicine Alberta, Calgary, AB T2N 1N4, Canada.
FAU - Otoch, Jose Pinhata
AU  - Otoch JP
AD  - Natural Products and Derivatives Laboratory (LIM-26), Department of Surgery, 
      University of Sao Paulo Medical School, Sao Paulo 01246-903, SP, Brazil.
AD  - Research and Development Efeom Nutrition S/A, Sao Paulo 03317-000, SP, Brazil.
FAU - Pessoa, Ana Flavia Marcal
AU  - Pessoa AFM
AD  - Natural Products and Derivatives Laboratory (LIM-26), Department of Surgery, 
      University of Sao Paulo Medical School, Sao Paulo 01246-903, SP, Brazil.
AD  - Research and Development Efeom Nutrition S/A, Sao Paulo 03317-000, SP, Brazil.
AD  - Brazilian Academic Consortium for Integrative Health (CABSIN), Natural Products 
      Committee, Sao Paulo 05449-070, SP, Brazil.
LA  - eng
GR  - 01/04-21/Efeom Nutrition S.A./
GR  - 2016/R1 Newton Grant-eGAP SZ50730/Royal Society of Medicine/
GR  - #312514/2019-0/National Council for Scientific and Technological Development/
PT  - Journal Article
DEP - 20220223
PL  - Switzerland
TA  - Antioxidants (Basel)
JT  - Antioxidants (Basel, Switzerland)
JID - 101668981
PMC - PMC8944780
OTO - NOTNLM
OT  - Interleukin-6
OT  - Pgc-1alpha
OT  - antioxidant enzymes
OT  - minerals
OT  - nutraceutical
OT  - obesity
OT  - prebiotic
OT  - silymarin
OT  - type-2 diabetes
OT  - yeast beta-glucan
COIS- The authors declare no conflict of interest.
EDAT- 2022/03/26 06:00
MHDA- 2022/03/26 06:01
PMCR- 2022/02/23
CRDT- 2022/03/25 01:00
PHST- 2022/02/07 00:00 [received]
PHST- 2022/02/18 00:00 [accepted]
PHST- 2022/03/25 01:00 [entrez]
PHST- 2022/03/26 06:00 [pubmed]
PHST- 2022/03/26 06:01 [medline]
PHST- 2022/02/23 00:00 [pmc-release]
AID - antiox11030447 [pii]
AID - antioxidants-11-00447 [pii]
AID - 10.3390/antiox11030447 [doi]
PST - epublish
SO  - Antioxidants (Basel). 2022 Feb 23;11(3):447. doi: 10.3390/antiox11030447.