PMID- 35326338
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220401
IS  - 2076-3425 (Print)
IS  - 2076-3425 (Electronic)
IS  - 2076-3425 (Linking)
VI  - 12
IP  - 3
DP  - 2022 Mar 12
TI  - Ketamine as a Novel Psychopharmacotherapy for Eating Disorders: Evidence and 
      Future Directions.
LID - 10.3390/brainsci12030382 [doi]
LID - 382
AB  - Eating disorders (EDs) are serious, life-threatening psychiatric conditions 
      associated with physical and psychosocial impairment, as well as high morbidity 
      and mortality. Given the chronic refractory nature of EDs and the paucity of 
      evidence-based treatments, there is a pressing need to identify novel approaches 
      for this population. The noncompetitive N-methyl-D-aspartate receptor (NMDAr) 
      antagonist, ketamine, has recently been approved for treatment-resistant 
      depression, exerting rapid and robust antidepressant effects. It is now being 
      investigated for several new indications, including obsessive-compulsive, 
      post-traumatic, and substance use disorder, and shows transdiagnostic potential 
      for EDs, particularly among clinical nonresponders. Hence, the aim of this review 
      is to examine contemporary findings on the treatment of EDs with ketamine, 
      whether used as a primary, adjunctive, or combination psychopharmacotherapy. 
      Avenues for future research are also discussed. Overall, results are encouraging 
      and point to therapeutic value; however, are limited to case series and reports 
      on anorexia nervosa. Further empirical research is thus needed to explore 
      ketamine efficacy across ED subgroups, establish safety profiles and optimize 
      dosing, and develop theory-driven, targeted treatment strategies at the 
      individual patient level.
FAU - Ragnhildstveit, Anya
AU  - Ragnhildstveit A
AUID- ORCID: 0000-0002-5796-3428
AD  - Department of Psychology and Neuroscience, Duke University, Durham, NC 27708, 
      USA.
AD  - Integrated Research Literacy Group, Draper, UT 84020, USA.
FAU - Slayton, Matthew
AU  - Slayton M
AD  - Department of Psychology and Neuroscience, Duke University, Durham, NC 27708, 
      USA.
AD  - Integrated Research Literacy Group, Draper, UT 84020, USA.
FAU - Jackson, Laura Kate
AU  - Jackson LK
AD  - Integrated Research Literacy Group, Draper, UT 84020, USA.
AD  - Novamind, Draper, UT 84020, USA.
FAU - Brendle, Madeline
AU  - Brendle M
AD  - Integrated Research Literacy Group, Draper, UT 84020, USA.
AD  - Novamind, Draper, UT 84020, USA.
AD  - Department of Pharmacotherapy, University of Utah College of Pharmacy, Salt Lake 
      City, UT 84112, USA.
FAU - Ahuja, Sachin
AU  - Ahuja S
AD  - Novamind, Draper, UT 84020, USA.
FAU - Holle, Willis
AU  - Holle W
AD  - Integrated Research Literacy Group, Draper, UT 84020, USA.
FAU - Moore, Claire
AU  - Moore C
AD  - Novamind, Draper, UT 84020, USA.
FAU - Sollars, Kellie
AU  - Sollars K
AD  - Novamind, Draper, UT 84020, USA.
FAU - Seli, Paul
AU  - Seli P
AD  - Department of Psychology and Neuroscience, Duke University, Durham, NC 27708, 
      USA.
FAU - Robison, Reid
AU  - Robison R
AD  - Novamind, Draper, UT 84020, USA.
AD  - Department of Psychiatry, University of Utah School of Medicine, Salt Lake City, 
      UT 84108, USA.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220312
PL  - Switzerland
TA  - Brain Sci
JT  - Brain sciences
JID - 101598646
PMC - PMC8963252
OTO - NOTNLM
OT  - anorexia nervosa
OT  - binge eating disorder
OT  - bulimia nervosa
OT  - eating disorder
OT  - esketamine
OT  - ketamine
OT  - ketamine-assisted psychotherapy
OT  - pharmacology
OT  - psychedelics
OT  - treatment
COIS- The authors declare no conflict of interest.
EDAT- 2022/03/26 06:00
MHDA- 2022/03/26 06:01
PMCR- 2022/03/12
CRDT- 2022/03/25 01:01
PHST- 2022/02/05 00:00 [received]
PHST- 2022/03/02 00:00 [revised]
PHST- 2022/03/09 00:00 [accepted]
PHST- 2022/03/25 01:01 [entrez]
PHST- 2022/03/26 06:00 [pubmed]
PHST- 2022/03/26 06:01 [medline]
PHST- 2022/03/12 00:00 [pmc-release]
AID - brainsci12030382 [pii]
AID - brainsci-12-00382 [pii]
AID - 10.3390/brainsci12030382 [doi]
PST - epublish
SO  - Brain Sci. 2022 Mar 12;12(3):382. doi: 10.3390/brainsci12030382.