PMID- 35327620
OWN - NLM
STAT- MEDLINE
DCOM- 20220429
LR  - 20231105
IS  - 2218-273X (Electronic)
IS  - 2218-273X (Linking)
VI  - 12
IP  - 3
DP  - 2022 Mar 10
TI  - Transplantation of Human Umbilical Cord Mesenchymal Stem Cells-Derived Neural 
      Stem Cells Pretreated with Neuregulin1beta Ameliorate Cerebral Ischemic Reperfusion 
      Injury in Rats.
LID - 428 [pii]
LID - 10.3390/biom12030428 [doi]
AB  - Ischemic stroke is a common cerebrovascular disease and recovering blood flow as 
      early as possible is essential to reduce ischemic damage and maintain neuronal 
      viability, but the reperfusion process usually causes additional damage to the 
      brain tissue in the ischemic area, namely ischemia reperfusion injury. The 
      accumulated studies have revealed that transplantation of exogenous neural stem 
      cells (NSCs) is an ideal choice for the treatment of ischemia reperfusion injury. 
      At present, the source and efficacy of exogenous NSCs after transplantation is 
      still one of the key issues that need to be resolved. In this study, human 
      umbilical cord mesenchymal stem cells (hUC-MSCs) were obtained and induced into 
      NSCs byadding growth factor and neuregulin1beta (NRG1beta) was introduced during the 
      differentiation process of NSCs. Then, the rat middle cerebral artery 
      occlusion/reperfusion (MCAO/R) models were established, and the therapeutic 
      effects were evaluated among groups treated by NRG1beta, NSCs and NSCs pretreated 
      with 10 nM NRG1beta (NSCs-10 nM NRG1beta) achieved through intra-arterial injection. 
      Our data show that the NSCs-10 nM NRG1beta group significantly improves 
      neurobehavioral function and infarct volume after MCAO/R, as well as cerebral 
      cortical neuron injury, ferroptosis-related indexes and mitochondrial injury. 
      Additionally, NSCs-10 nM NRG1beta intervention may function through regulating the 
      p53/GPX4/SLC7A11 pathway, and reducing the level of ferroptosis in cells, further 
      enhance the neuroprotective effect on injured cells.
FAU - Zhai, Qiu-Yue
AU  - Zhai QY
AD  - Institute of Cerebrovascular Diseases, Medical Research Center, The Affiliated 
      Hospital of Qingdao University, Taishan Scholars Construction Project Excellent 
      Innovative Team of Shandong Province, Qingdao 266003, China.
FAU - Ren, Yu-Qian
AU  - Ren YQ
AD  - Institute of Cerebrovascular Diseases, Medical Research Center, The Affiliated 
      Hospital of Qingdao University, Taishan Scholars Construction Project Excellent 
      Innovative Team of Shandong Province, Qingdao 266003, China.
FAU - Ni, Qin-Shuai
AU  - Ni QS
AD  - Institute of Cerebrovascular Diseases, Medical Research Center, The Affiliated 
      Hospital of Qingdao University, Taishan Scholars Construction Project Excellent 
      Innovative Team of Shandong Province, Qingdao 266003, China.
FAU - Song, Zhen-Hua
AU  - Song ZH
AD  - Institute of Pharmacology, Qingdao Medical College, Qingdao University, Qingdao 
      266021, China.
FAU - Ge, Ke-Li
AU  - Ge KL
AD  - Institute of Integrative Medicine, Qingdao Medical College, Qingdao University, 
      Qingdao 266021, China.
FAU - Guo, Yun-Liang
AU  - Guo YL
AD  - Institute of Cerebrovascular Diseases, Medical Research Center, The Affiliated 
      Hospital of Qingdao University, Taishan Scholars Construction Project Excellent 
      Innovative Team of Shandong Province, Qingdao 266003, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220310
PL  - Switzerland
TA  - Biomolecules
JT  - Biomolecules
JID - 101596414
SB  - IM
MH  - Animals
MH  - Humans
MH  - Infarction, Middle Cerebral Artery/metabolism/therapy
MH  - *Mesenchymal Stem Cells/metabolism
MH  - *Neural Stem Cells/metabolism
MH  - Rats
MH  - *Reperfusion Injury/therapy
MH  - Umbilical Cord
PMC - PMC8945978
OTO - NOTNLM
OT  - ferroptosis
OT  - middle cerebral artery occlusion/reperfusion
OT  - neural stem cells
OT  - neuregulin1beta
OT  - transplantation
EDAT- 2022/03/26 06:00
MHDA- 2022/04/30 06:00
CRDT- 2022/03/25 01:04
PHST- 2022/01/25 00:00 [received]
PHST- 2022/02/28 00:00 [revised]
PHST- 2022/03/07 00:00 [accepted]
PHST- 2022/03/25 01:04 [entrez]
PHST- 2022/03/26 06:00 [pubmed]
PHST- 2022/04/30 06:00 [medline]
AID - biom12030428 [pii]
AID - 10.3390/biom12030428 [doi]
PST - epublish
SO  - Biomolecules. 2022 Mar 10;12(3):428. doi: 10.3390/biom12030428.