PMID- 35328079
OWN - NLM
STAT- MEDLINE
DCOM- 20220425
LR  - 20220531
IS  - 2073-4425 (Electronic)
IS  - 2073-4425 (Linking)
VI  - 13
IP  - 3
DP  - 2022 Mar 16
TI  - Association of Myocardial Infarction with CDKN2B Antisense RNA 1 (CDKN2B-AS1) 
      rs1333049 Polymorphism in Slovenian Subjects with Type 2 Diabetes Mellitus.
LID - 10.3390/genes13030526 [doi]
LID - 526
AB  - BACKGROUND: We examined the role of rs1333049 polymorphism of the CDKN2B 
      Antisense RNA 1 (CDKN2B-AS1) on the prevalence of myocardial infarction (MI) in 
      Slovenian subjects with type 2 diabetes mellitus (T2DM). METHODS: A total of 1071 
      subjects with T2DM were enrolled in this retrospective cross-sectional 
      case-control study. Of the subjects, 334 had a history of recent MI, and 737 
      subjects in the control group had no clinical signs of coronary artery disease 
      (CAD). With logistic regression, we performed a genetic analysis of rs1333049 
      polymorphism in all subjects. RESULTS: The C allele of rs1333049 polymorphism was 
      statistically more frequent in MI subjects (p = 0.05). Subjects with CC genotype 
      had a higher prevalence of MI than the control group in the co-dominant (AOR 
      1.50, CI 1.02-2.21, p = 0.04) and recessive (AOR 1.38, CI 1.09-1.89, p = 0.04) 
      genetic model. CONCLUSIONS: According to our study, the C allele and CC genotype 
      of rs1333049 polymorphism of CDKN2B-AS1 are possible markers of MI in T2DM 
      subjects in the Slovenian population.
FAU - Tibaut, Miha
AU  - Tibaut M
AUID- ORCID: 0000-0001-8653-262X
AD  - Department of Internal Medicine, General Hospital of Murska Sobota, Ul. dr. 
      Vrbnjaka 6, 9000 Murska Sobota, Slovenia.
FAU - Naji, Franjo
AU  - Naji F
AD  - Department for Cardiology and Angiology, Clinic for Internal Medicine, University 
      Medical Centre Maribor, 2000 Maribor, Slovenia.
AD  - Department of Internal Medicine, Faculty of Medicine, University of Maribor, 2000 
      Maribor, Slovenia.
FAU - Petrovic, Daniel
AU  - Petrovic D
AD  - Institute of Histology and Embryology, Faculty of Medicine, University of 
      Ljubljana, Korytkova 2, 1105 Ljubljana, Slovenia.
AD  - International Centre for Cardiovascular Diseases MC Medicord.d., 6310 Izola, 
      Slovenia.
LA  - eng
PT  - Journal Article
DEP - 20220316
PL  - Switzerland
TA  - Genes (Basel)
JT  - Genes
JID - 101551097
RN  - 0 (RNA, Antisense)
RN  - 0 (RNA, Long Noncoding)
SB  - IM
MH  - Case-Control Studies
MH  - Cross-Sectional Studies
MH  - *Diabetes Mellitus, Type 2/epidemiology/genetics
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - *Myocardial Infarction/epidemiology/genetics
MH  - Polymorphism, Single Nucleotide
MH  - *RNA, Antisense/genetics
MH  - *RNA, Long Noncoding/genetics
MH  - Retrospective Studies
MH  - Slovenia
PMC - PMC8952457
OTO - NOTNLM
OT  - CDKN2B-AS1
OT  - Cyclin Dependent Kinase Inhibitor 2B Antisense RNA 1
OT  - coronary artery disease
OT  - myocardial infarction
OT  - rs1333049
OT  - type 2 diabetes mellitus
COIS- The authors declare no conflict of interest.
EDAT- 2022/03/26 06:00
MHDA- 2022/04/26 06:00
PMCR- 2022/03/16
CRDT- 2022/03/25 01:06
PHST- 2022/02/21 00:00 [received]
PHST- 2022/03/14 00:00 [revised]
PHST- 2022/03/15 00:00 [accepted]
PHST- 2022/03/25 01:06 [entrez]
PHST- 2022/03/26 06:00 [pubmed]
PHST- 2022/04/26 06:00 [medline]
PHST- 2022/03/16 00:00 [pmc-release]
AID - genes13030526 [pii]
AID - genes-13-00526 [pii]
AID - 10.3390/genes13030526 [doi]
PST - epublish
SO  - Genes (Basel). 2022 Mar 16;13(3):526. doi: 10.3390/genes13030526.