PMID- 35328328
OWN - NLM
STAT- MEDLINE
DCOM- 20220408
LR  - 20220408
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 23
IP  - 6
DP  - 2022 Mar 8
TI  - Piezoelectric Electrospun Fibrous Scaffolds for Bone, Articular Cartilage and 
      Osteochondral Tissue Engineering.
LID - 10.3390/ijms23062907 [doi]
LID - 2907
AB  - Osteochondral tissue (OCT) related diseases, particularly osteoarthritis, number 
      among the most prevalent in the adult population worldwide. However, no 
      satisfactory clinical treatments have been developed to date to resolve this 
      unmet medical issue. Osteochondral tissue engineering (OCTE) strategies involving 
      the fabrication of OCT-mimicking scaffold structures capable of replacing damaged 
      tissue and promoting its regeneration are currently under development. While the 
      piezoelectric properties of the OCT have been extensively reported in different 
      studies, they keep being neglected in the design of novel OCT scaffolds, which 
      focus primarily on the tissue's structural and mechanical properties. Given the 
      promising potential of piezoelectric electrospun scaffolds capable of both 
      recapitulating the piezoelectric nature of the tissue's fibrous ECM and of 
      providing a platform for electrical and mechanical stimulation to promote the 
      regeneration of damaged OCT, the present review aims to examine the current state 
      of the art of these electroactive smart scaffolds in OCTE strategies. A summary 
      of the piezoelectric properties of the different regions of the OCT and an 
      overview of the main piezoelectric biomaterials applied in OCTE applications are 
      presented. Some recent examples of piezoelectric electrospun scaffolds developed 
      for potentially replacing damaged OCT as well as for the bone or articular 
      cartilage segments of this interfacial tissue are summarized. Finally, the 
      current challenges and future perspectives concerning the use of piezoelectric 
      electrospun scaffolds in OCT regeneration are discussed.
FAU - Barbosa, Frederico
AU  - Barbosa F
AD  - iBB-Institute for Bioengineering and Biosciences, Department of Bioengineering, 
      Instituto Superior Tecnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 
      Lisboa, Portugal.
AD  - Associate Laboratory i4HB-Institute for Health and Bioeconomy, Instituto Superior 
      Tecnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal.
FAU - Ferreira, Frederico Castelo
AU  - Ferreira FC
AUID- ORCID: 0000-0001-5177-6237
AD  - iBB-Institute for Bioengineering and Biosciences, Department of Bioengineering, 
      Instituto Superior Tecnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 
      Lisboa, Portugal.
AD  - Associate Laboratory i4HB-Institute for Health and Bioeconomy, Instituto Superior 
      Tecnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal.
FAU - Silva, Joao Carlos
AU  - Silva JC
AUID- ORCID: 0000-0003-4773-6771
AD  - iBB-Institute for Bioengineering and Biosciences, Department of Bioengineering, 
      Instituto Superior Tecnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 
      Lisboa, Portugal.
AD  - Associate Laboratory i4HB-Institute for Health and Bioeconomy, Instituto Superior 
      Tecnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal.
AD  - CDRSP-Centre for Rapid and Sustainable Product Development, Polytechnic of 
      Leiria, Rua de Portugal-Zona Industrial, 2430-028 Marinha Grande, Portugal.
LA  - eng
GR  - InSilico4OCReg (PTDC/EME-SIS/0838/2021); OptiBioScaffold 
      (PTDC/EME-SIS/4446/2020); iBB (UIDB/04565/2020 and UIDP/04565/2020), CDRSP 
      (UIDB/04044/2020 and UIDP/04044/2020) and i4HB (LA/P/0140/2020)/Fundacao para a 
      Ciencia e Tecnologia/
PT  - Journal Article
PT  - Review
DEP - 20220308
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Biocompatible Materials)
SB  - IM
MH  - Biocompatible Materials/chemistry
MH  - Bone and Bones
MH  - *Cartilage, Articular
MH  - *Tissue Engineering
MH  - Tissue Scaffolds/chemistry
PMC - PMC8952277
OTO - NOTNLM
OT  - articular cartilage
OT  - bone
OT  - electrospinning
OT  - osteochondral tissue
OT  - piezoelectric fibrous scaffolds
OT  - tissue engineering
COIS- The authors declare no conflict of interest.
EDAT- 2022/03/26 06:00
MHDA- 2022/04/09 06:00
PMCR- 2022/03/08
CRDT- 2022/03/25 01:06
PHST- 2022/01/17 00:00 [received]
PHST- 2022/02/26 00:00 [revised]
PHST- 2022/03/02 00:00 [accepted]
PHST- 2022/03/25 01:06 [entrez]
PHST- 2022/03/26 06:00 [pubmed]
PHST- 2022/04/09 06:00 [medline]
PHST- 2022/03/08 00:00 [pmc-release]
AID - ijms23062907 [pii]
AID - ijms-23-02907 [pii]
AID - 10.3390/ijms23062907 [doi]
PST - epublish
SO  - Int J Mol Sci. 2022 Mar 8;23(6):2907. doi: 10.3390/ijms23062907.