PMID- 35328573
OWN - NLM
STAT- MEDLINE
DCOM- 20220408
LR  - 20220408
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 23
IP  - 6
DP  - 2022 Mar 15
TI  - Bee Venom and Its Major Component Melittin Attenuated Cutibacterium acnes- and 
      IGF-1-Induced Acne Vulgaris via Inactivation of Akt/mTOR/SREBP Signaling Pathway.
LID - 10.3390/ijms23063152 [doi]
LID - 3152
AB  - Acne vulgaris is the most common disease of the pilosebaceous unit. The 
      pathogenesis of this disease is complex, involving increased sebum production and 
      perifollicular inflammation. Understanding the factors that regulate sebum 
      production is important in identifying novel therapeutic targets for the 
      treatment of acne. Bee Venom (BV) and melittin have multiple effects including 
      antibacterial, antiviral, and anti-inflammatory activities in various cell types. 
      However, the anti-lipogenic mechanisms of BV and melittin have not been 
      elucidated. We investigated the effects of BV and melittin in models of 
      Insulin-like growth factor-1 (IGF-1) or Cutibacterium acnes (C. acnes)-induced 
      lipogenic skin disease. C. acnes or IGF-1 increased the expression of sterol 
      regulatory element-binding protein-1 (SREBP-1) and proliferator-activated 
      receptor gamma (PPAR-gamma), transcription factors that regulate numerous genes 
      involved in lipid biosynthesis through the protein kinase B (Akt)/mammalian 
      target of rapamycin (mTOR)/SREBP signaling pathway. In this study using a C. 
      acnes or IGF-1 stimulated lipogenic disease model, BV and melittin inhibited the 
      increased expression of lipogenic and pro-inflammatory factor through the 
      blockade of the Akt/mTOR/SREBP signaling pathway. This study suggests for the 
      first time that BV and melittin could be developed as potential natural anti-acne 
      agents with anti-lipogenesis, anti-inflammatory, and anti-C. acnes activity.
FAU - Gu, Hyemin
AU  - Gu H
AD  - Department of Pathology, School of Medicine, Catholic University of Daegu, 
      Gyeongsan 42472, Korea.
FAU - An, Hyun-Jin
AU  - An HJ
AD  - Department of Pathology, School of Medicine, Catholic University of Daegu, 
      Gyeongsan 42472, Korea.
FAU - Gwon, Mi-Gyeong
AU  - Gwon MG
AD  - Department of Pathology, School of Medicine, Catholic University of Daegu, 
      Gyeongsan 42472, Korea.
FAU - Bae, Seongjae
AU  - Bae S
AD  - Department of Pathology, School of Medicine, Catholic University of Daegu, 
      Gyeongsan 42472, Korea.
FAU - Leem, Jaechan
AU  - Leem J
AUID- ORCID: 0000-0003-2329-4374
AD  - Department of Immunology, School of Medicine, Catholic University of Daegu, 
      Gyeongsan 42472, Korea.
FAU - Lee, Sun-Jae
AU  - Lee SJ
AUID- ORCID: 0000-0002-8552-6049
AD  - Department of Pathology, School of Medicine, Catholic University of Daegu, 
      Gyeongsan 42472, Korea.
FAU - Han, Sang-Mi
AU  - Han SM
AUID- ORCID: 0000-0002-6840-4509
AD  - Department of Agricultural Biology, National Academy of Agricultural Science, 
      RDA, Wanju 54875, Korea.
FAU - Zouboulis, Christos C
AU  - Zouboulis CC
AUID- ORCID: 0000-0003-1646-2608
AD  - Departments of Dermatology, Venereology, Allergology and Immunology, Dessau 
      Medical Center, Brandenburg Medical School Theodor Fontane, Faculty of Health 
      Sciences Brandenburg, Auenweg 38, 06847 Dessau, Germany.
FAU - Park, Kwan-Kyu
AU  - Park KK
AD  - Department of Pathology, School of Medicine, Catholic University of Daegu, 
      Gyeongsan 42472, Korea.
LA  - eng
GR  - PJ015634/This work was carried out with the support of "Cooperative Research 
      Program for Agriculture Science and Technology Development (Project No. 
      PJ015634)" Rural Development Administration, Republic of Korea./
PT  - Journal Article
DEP - 20220315
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Bee Venoms)
RN  - 0 (Sterol Regulatory Element Binding Protein 1)
RN  - 20449-79-0 (Melitten)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
RN  - W36ZG6FT64 (Sirolimus)
SB  - IM
MH  - *Acne Vulgaris/drug therapy
MH  - Anti-Inflammatory Agents/pharmacology
MH  - *Bee Venoms/pharmacology
MH  - Humans
MH  - Insulin-Like Growth Factor I/pharmacology
MH  - Melitten/pharmacology
MH  - Propionibacterium acnes
MH  - Proto-Oncogene Proteins c-akt/metabolism
MH  - Signal Transduction
MH  - Sirolimus/pharmacology
MH  - Sterol Regulatory Element Binding Protein 1/metabolism
MH  - TOR Serine-Threonine Kinases/metabolism
PMC - PMC8953527
OTO - NOTNLM
OT  - C. acnes
OT  - IGF-1
OT  - bee venom
OT  - lipogenesis
OT  - melittin
COIS- The authors declare no conflict of interest.
EDAT- 2022/03/26 06:00
MHDA- 2022/04/09 06:00
PMCR- 2022/03/15
CRDT- 2022/03/25 01:07
PHST- 2022/02/08 00:00 [received]
PHST- 2022/03/07 00:00 [revised]
PHST- 2022/03/09 00:00 [accepted]
PHST- 2022/03/25 01:07 [entrez]
PHST- 2022/03/26 06:00 [pubmed]
PHST- 2022/04/09 06:00 [medline]
PHST- 2022/03/15 00:00 [pmc-release]
AID - ijms23063152 [pii]
AID - ijms-23-03152 [pii]
AID - 10.3390/ijms23063152 [doi]
PST - epublish
SO  - Int J Mol Sci. 2022 Mar 15;23(6):3152. doi: 10.3390/ijms23063152.