PMID- 35328581
OWN - NLM
STAT- MEDLINE
DCOM- 20220408
LR  - 20230415
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 23
IP  - 6
DP  - 2022 Mar 15
TI  - Self-Antigens Targeted by Regulatory T Cells in Type 1 Diabetes.
LID - 10.3390/ijms23063155 [doi]
LID - 3155
AB  - While progress has been made toward understanding mechanisms that lead to the 
      development of autoimmunity, there is less knowledge regarding protective 
      mechanisms from developing such diseases. For example, in type 1 diabetes (T1D), 
      the immune-mediated form of diabetes, the role of pathogenic T cells in the 
      destruction of pancreatic islets is well characterized, but immune-mediated 
      mechanisms that contribute to T1D protection have not been fully elucidated. One 
      potential protective mechanism includes the suppression of immune responses by 
      regulatory CD4 T cells (Tregs) that recognize self-peptides from islets presented 
      by human leukocyte antigen (HLA) class II molecules. In this review, we summarize 
      what is known about the antigenic self-peptides recognized by Tregs in the 
      context of T1D.
FAU - Mitchell, Angela M
AU  - Mitchell AM
AUID- ORCID: 0000-0003-1955-5850
AD  - Barbara Davis Center for Diabetes, University of Colorado, Aurora, CO 80045, USA.
FAU - Michels, Aaron W
AU  - Michels AW
AUID- ORCID: 0000-0003-3766-5244
AD  - Barbara Davis Center for Diabetes, University of Colorado, Aurora, CO 80045, USA.
LA  - eng
GR  - 2103-05093/Leona M. and Harry B. Helmsley Charitable Trust/
GR  - P30 DK116073/DK/NIDDK NIH HHS/United States
GR  - 3-PDF-2020-943-A-N/JDRF/Juvenile Diabetes Research Foundation/United States
GR  - DK108868, DK110845, DK032083, DK099317, DK032493, DK116073/DK/NIDDK NIH 
      HHS/United States
GR  - R01 DK032083/DK/NIDDK NIH HHS/United States
GR  - R01 DK108868/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20220315
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Autoantigens)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Autoantigens
MH  - Autoimmunity
MH  - *Diabetes Mellitus, Type 1/pathology
MH  - HLA Antigens
MH  - Humans
MH  - *Islets of Langerhans/pathology
MH  - T-Lymphocytes, Regulatory
PMC - PMC8954990
OTO - NOTNLM
OT  - antigen-specific therapy
OT  - islet autoimmunity
OT  - regulatory T cells
OT  - type 1 diabetes
COIS- The authors declare no conflict of interest.
EDAT- 2022/03/26 06:00
MHDA- 2022/04/09 06:00
PMCR- 2022/03/15
CRDT- 2022/03/25 01:07
PHST- 2022/02/04 00:00 [received]
PHST- 2022/03/03 00:00 [revised]
PHST- 2022/03/12 00:00 [accepted]
PHST- 2022/03/25 01:07 [entrez]
PHST- 2022/03/26 06:00 [pubmed]
PHST- 2022/04/09 06:00 [medline]
PHST- 2022/03/15 00:00 [pmc-release]
AID - ijms23063155 [pii]
AID - ijms-23-03155 [pii]
AID - 10.3390/ijms23063155 [doi]
PST - epublish
SO  - Int J Mol Sci. 2022 Mar 15;23(6):3155. doi: 10.3390/ijms23063155.