PMID- 35329085
OWN - NLM
STAT- MEDLINE
DCOM- 20220418
LR  - 20220418
IS  - 1660-4601 (Electronic)
IS  - 1661-7827 (Print)
IS  - 1660-4601 (Linking)
VI  - 19
IP  - 6
DP  - 2022 Mar 14
TI  - Association between Clinical Use of Colchicine and Risk of Type 2 Diabetes 
      Mellitus among Gouty Patients: A Nationwide Cohort Study.
LID - 10.3390/ijerph19063395 [doi]
LID - 3395
AB  - BACKGROUND: Gout is the most common form of inflammatory arthritis in adults. 
      Even though a link between gouty arthritis and type 2 diabetes mellitus (T2DM) 
      has been reported, there is a limited understanding of the association between 
      the anti-inflammatory agent colchicine and the risk of T2DM. This aim of this 
      study was to assess the association between the use of colchicine and the risk of 
      T2DM in an Asian cohort. METHODS: A retrospective cohort study was conducted 
      using the National Health Insurance Research Database (NHIRD) in Taiwan from 2000 
      to 2013. The study cohorts comprised 3841 gouty patients using colchicine (the 
      exposed cohort) and 7682 gouty patients not using colchicine (the unexposed 
      -cohort). The primary outcome was incident DM. The hazard ratios (HRs) and 95% 
      confidence intervals (CIs) derived from a Cox proportional regression model were 
      used to assess the association between colchicine use and the risk of diabetes. 
      RESULTS: The cumulative incidence of T2DM was significantly lower in the exposed 
      cohort (18.8%) than in the unexposed cohort (25.0%). The risk of T2DM was 
      significantly lower in colchicine users than in non-users (adjusted HR, 0.74; 95% 
      CI, 0.36-0.87). The inverse relationship between colchicine use and diabetes risk 
      remained consistent across sex and age groups. CONCLUSIONS: This cohort study 
      provides longitudinal evidence that the use of colchicine is associated with a 
      reduced risk of T2DM. This conclusion, however, needs to be interpreted 
      cautiously given the lack of body mass index data in the NHIRD. Further studies 
      are needed to determine the clinical implications of this study.
FAU - Chu, Chen-Chih
AU  - Chu CC
AUID- ORCID: 0000-0002-1599-0305
AD  - Division of Rheumatology/Immunology and Allergy, Department of Internal Medicine, 
      Tri-Service General Hospital, National Defense Medical Center, Taipei 114, 
      Taiwan.
FAU - Chen, Yong-Chen
AU  - Chen YC
AUID- ORCID: 0000-0003-1007-3003
AD  - Data Science Center, College of Medicine, Fu-Jen Catholic University, New Taipei 
      City 242, Taiwan.
AD  - Department of Medicine, College of Medicine, Fu-Jen Catholic University, New 
      Taipei City 242, Taiwan.
FAU - Lin, Ming-Hsun
AU  - Lin MH
AUID- ORCID: 0000-0003-4169-921X
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      Tri-Service General Hospital, National Defense Medical Center, Taipei 114, 
      Taiwan.
FAU - Wu, Wen-Tung
AU  - Wu WT
AD  - Department of Pharmacy, Tri-Service General Hospital, National Defense Medical 
      Center, Taipei 114, Taiwan.
FAU - Liu, Feng-Cheng
AU  - Liu FC
AD  - Division of Rheumatology/Immunology and Allergy, Department of Internal Medicine, 
      Tri-Service General Hospital, National Defense Medical Center, Taipei 114, 
      Taiwan.
FAU - Chen, Hsiang-Cheng
AU  - Chen HC
AD  - Division of Rheumatology/Immunology and Allergy, Department of Internal Medicine, 
      Tri-Service General Hospital, National Defense Medical Center, Taipei 114, 
      Taiwan.
FAU - Chou, Yu-Ching
AU  - Chou YC
AUID- ORCID: 0000-0003-4823-6541
AD  - School of Public Health, National Defense Medical Center, Taipei 114, Taiwan.
FAU - Sun, Chien-An
AU  - Sun CA
AUID- ORCID: 0000-0001-9041-0537
AD  - Data Science Center, College of Medicine, Fu-Jen Catholic University, New Taipei 
      City 242, Taiwan.
AD  - Department of Public Health, College of Medicine, Fu-Jen Catholic University, No. 
      510, Zhongzheng Road, Xinzhuang District, New Taipei City 24205, Taiwan.
LA  - eng
PT  - Journal Article
DEP - 20220314
PL  - Switzerland
TA  - Int J Environ Res Public Health
JT  - International journal of environmental research and public health
JID - 101238455
RN  - SML2Y3J35T (Colchicine)
SB  - IM
MH  - Adult
MH  - Cohort Studies
MH  - Colchicine/adverse effects
MH  - *Diabetes Mellitus, Type 2/drug therapy/epidemiology/etiology
MH  - *Gout/drug therapy/epidemiology
MH  - Humans
MH  - Incidence
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Taiwan/epidemiology
PMC - PMC8955765
OTO - NOTNLM
OT  - cohort study
OT  - colchicine
OT  - diabetes mellitus
OT  - gout
COIS- The authors declare that they have no competing interest.
EDAT- 2022/03/26 06:00
MHDA- 2022/04/19 06:00
PMCR- 2022/03/14
CRDT- 2022/03/25 01:09
PHST- 2022/03/02 00:00 [received]
PHST- 2022/03/08 00:00 [revised]
PHST- 2022/03/10 00:00 [accepted]
PHST- 2022/03/25 01:09 [entrez]
PHST- 2022/03/26 06:00 [pubmed]
PHST- 2022/04/19 06:00 [medline]
PHST- 2022/03/14 00:00 [pmc-release]
AID - ijerph19063395 [pii]
AID - ijerph-19-03395 [pii]
AID - 10.3390/ijerph19063395 [doi]
PST - epublish
SO  - Int J Environ Res Public Health. 2022 Mar 14;19(6):3395. doi: 
      10.3390/ijerph19063395.