PMID- 3532932
OWN - NLM
STAT- MEDLINE
DCOM- 19861118
LR  - 20061115
IS  - 0364-5134 (Print)
IS  - 0364-5134 (Linking)
VI  - 20
IP  - 3
DP  - 1986 Sep
TI  - HLA study of Japanese patients with Creutzfeldt-Jakob disease: significant 
      association with HLA-DQw3.
PG  - 356-9
AB  - To demonstrate genetic susceptibility to Creutzfeldt-Jakob disease (CJD), 10 
      Japanese patients with pathologically proved CJD and 6 patients with clinically 
      definite CJD were tissue typed for 48 class I and 14 class II human leukocyte 
      antigen (HLA) specificities. The patients were scattered throughout Japan and 
      there were no consanguineous relationships. Among 62 HLA specificities, HLA-DRw53 
      and DQw3 were found in all pathologically proved CJD cases. When the frequencies 
      of the HLA antigens in the 16 CJD cases were compared to those of normal 
      Japanese, a highly significant (p less than 0.005) increase was found for 
      HLA-DQw3 in the CJD group. The present findings provide evidence for genetic 
      control of susceptibility to CJD in humans.
FAU - Kuroda, Y
AU  - Kuroda Y
FAU - Kaneoka, H
AU  - Kaneoka H
FAU - Shibasaki, H
AU  - Shibasaki H
FAU - Kume, S
AU  - Kume S
FAU - Yamaguchi, M
AU  - Yamaguchi M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Ann Neurol
JT  - Annals of neurology
JID - 7707449
RN  - 0 (HLA-D Antigens)
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - Aged
MH  - Brain/pathology
MH  - Creutzfeldt-Jakob Syndrome/*genetics/pathology
MH  - Female
MH  - HLA-D Antigens/*analysis
MH  - HLA-DR Antigens/*analysis
MH  - Humans
MH  - Japan
MH  - Male
MH  - Middle Aged
EDAT- 1986/09/01 00:00
MHDA- 1986/09/01 00:01
CRDT- 1986/09/01 00:00
PHST- 1986/09/01 00:00 [pubmed]
PHST- 1986/09/01 00:01 [medline]
PHST- 1986/09/01 00:00 [entrez]
AID - 10.1002/ana.410200314 [doi]
PST - ppublish
SO  - Ann Neurol. 1986 Sep;20(3):356-9. doi: 10.1002/ana.410200314.