PMID- 35331018 OWN - NLM STAT- MEDLINE DCOM- 20220613 LR - 20231006 IS - 1477-0873 (Electronic) IS - 0269-2155 (Linking) VI - 36 IP - 7 DP - 2022 Jul TI - High-intensity versus low-intensity resistance training in patients with knee osteoarthritis: A randomized controlled trial. PG - 952-967 LID - 10.1177/02692155211073039 [doi] AB - OBJECTIVES: To assess whether (i) high-intensity resistance training (RT) leads to increased muscle strength compared to low-intensity RT in patients with knee osteoarthritis (OA); and (ii) RT with vitamin D supplementation leads to increased muscle strength compared to placebo in a subgroup with vitamin D deficiency. DESIGN: Randomized controlled trial. SETTING: Outpatient rehabilitation centre. SUBJECTS: Patients with knee OA. INTERVENTIONS: 12 weeks of RT at high-intensity RT (70-80% of 1-repetition maximum (1-RM)) or low-intensity RT (40-50% of 1-RM) and 24 weeks of vitamin D (1200 International units vitamin D3 per day) or placebo supplementation. MAIN MEASURES: Primary outcome measure was isokinetic muscle strength. Other outcome measure for muscle strength was the estimated 1-RM. Secondary outcome measures were knee pain and physical functioning. RESULTS: 177 participants with a mean age of 67.6 +/- 5.8 years were included, of whom 50 had vitamin D deficiency. Isokinetic muscle strength (in Newton metre per kilogram bodyweight) at start, end and 24 weeks after the RT was 0.98 +/- 0.40, 1.11 +/- 0.40, 1.09 +/- 0.42 in the high-intensity group and 1.02 +/- 0.41, 1.15 +/- 0.42, 1.12 +/- 0.40 in the low-intensity group, respectively. No differences were found between the groups, except for the estimated 1-RM in favour of the high-intensity group. In the subgroup with vitamin D deficiency, no difference on isokinetic muscle strength was found between the vitamin D and placebo group. CONCLUSIONS: High-intensity RT did not result in greater improvements in isokinetic muscle strength, pain and physical functioning compared to low-intensity RT in knee OA, but was well tolerated. Therefore these results suggest that either intensity of resistance training could be utilised in exercise programmes for patients with knee osteoarthritis. No synergistic effect of vitamin D supplementation and RT was found, but this finding was based on underpowered data. FAU - de Zwart, Arjan H AU - de Zwart AH AUID- ORCID: 0000-0002-8174-5447 AD - Reade, Amsterdam Rehabilitation Research Centre, Amsterdam, The Netherlands. FAU - Dekker, Joost AU - Dekker J AUID- ORCID: 0000-0003-2027-0027 AD - Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Rehabilitation Medicine, Amsterdam, the Netherlands. AD - Amsterdam Public Health research institute, Amsterdam UMC, Amsterdam, the Netherlands. FAU - Roorda, Leo D AU - Roorda LD AD - Reade, Amsterdam Rehabilitation Research Centre, Amsterdam, The Netherlands. FAU - van der Esch, Martin AU - van der Esch M AD - Reade, Amsterdam Rehabilitation Research Centre, Amsterdam, The Netherlands. AD - Center of expertise Urban Vitality, Amsterdam University of Applied Sciences, Amsterdam, The Netherlands. FAU - Lips, Paul AU - Lips P AD - Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Internal Medicine, Endocrine Section, VU University Medical Center, Amsterdam, The Netherlands. FAU - van Schoor, Natasja M AU - van Schoor NM AD - Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Epidemiology and Data Science, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands. FAU - Heijboer, Annemiek C AU - Heijboer AC AD - Amsterdam UMC, Vrije Universiteit Amsterdam, Endocrine Laboratory, Department of Clinical Chemistry, Amsterdam, the Netherlands. AD - Amsterdam UMC, University of Amsterdam, Laboratory of Endocrinology, Department of Clinical Chemistry, Amsterdam, the Netherlands. FAU - Turkstra, Franktien AU - Turkstra F AD - Amsterdam Rheumatology and Immunology Center, Reade, Amsterdam, Netherlands. FAU - Gerritsen, Martijn AU - Gerritsen M AD - Amsterdam Rheumatology and Immunology Center, Reade, Amsterdam, Netherlands. FAU - Hakkinen, Arja AU - Hakkinen A AD - Health Sciences in the Faculty of Sport and Health Sciences, University of Jyvaskyla, Jyvaskyla, Finland. AD - Central Finland Health Care District, Jyvaskyla, Finland. FAU - Bennell, Kim AU - Bennell K AD - Centre for Health, Exercise and Sports Medicine, Department of Physiotherapy, University of Melbourne, Melbourne, Victoria, Australia. FAU - Steultjens, Martjin Pm AU - Steultjens MP AD - 3525Glasgow Caledonian University, School of Health and Life Sciences, Glasgow, UK. FAU - Lems, Willem F AU - Lems WF AD - Amsterdam Rheumatology and Immunology Center, Reade, Amsterdam, Netherlands. AD - Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Rheumatology, Amsterdam Movement Sciences, Amsterdam, Netherlands. FAU - van der Leeden, Marike AU - van der Leeden M AD - Reade, Amsterdam Rehabilitation Research Centre, Amsterdam, The Netherlands. AD - Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Rehabilitation Medicine, Amsterdam, the Netherlands. AD - Amsterdam Public Health research institute, Amsterdam UMC, Amsterdam, the Netherlands. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20220325 PL - England TA - Clin Rehabil JT - Clinical rehabilitation JID - 8802181 RN - 1406-16-2 (Vitamin D) SB - IM CIN - J Physiother. 2023 Oct;69(4):270. PMID: 37661512 MH - Aged MH - Humans MH - Middle Aged MH - Muscle Strength/physiology MH - *Osteoarthritis, Knee/rehabilitation MH - Pain MH - *Resistance Training/methods MH - Vitamin D MH - *Vitamin D Deficiency OTO - NOTNLM OT - knee osteoarthritis OT - muscle strength OT - resistance training OT - vitamin D EDAT- 2022/03/26 06:00 MHDA- 2022/06/14 06:00 CRDT- 2022/03/25 05:30 PHST- 2022/03/26 06:00 [pubmed] PHST- 2022/06/14 06:00 [medline] PHST- 2022/03/25 05:30 [entrez] AID - 10.1177/02692155211073039 [doi] PST - ppublish SO - Clin Rehabil. 2022 Jul;36(7):952-967. doi: 10.1177/02692155211073039. Epub 2022 Mar 25.