PMID- 35332564
OWN - NLM
STAT- MEDLINE
DCOM- 20220708
LR  - 20220930
IS  - 1745-4514 (Electronic)
IS  - 0145-8884 (Linking)
VI  - 46
IP  - 7
DP  - 2022 Jul
TI  - Effects of medical plants from Zingiberaceae family on cardiovascular risk 
      factors of type 2 diabetes mellitus: A systematic review and meta-analysis of 
      randomized controlled trials.
PG  - e14130
LID - 10.1111/jfbc.14130 [doi]
AB  - We performed a meta-analysis on randomized controlled trials (RCTs) to evaluate 
      the efficacy of Zingiberaceae on cardiovascular risk factors in type 2 diabetes 
      mellitus (T2DM). PubMed, Web of Science, Embase, The Cochrane Library, and Scopus 
      were searched systematically until October 18, 2021. Thirty-four RCTs with 2154 
      patients met our inclusion. Pooled analysis indicated that Zingiberaceae can 
      significantly improve body weight (BW) (WMD = -1.012, 95% CI: -1.673, -0.351, p = 
      .003), fasting blood glucose (FBG) (WMD = -14.292, 95% CI: -18.588, -9.995, p < 
      .001), glycosylated hemoglobin 1c (HbA1c) (WMD = -0.432, 95% CI: -0.607, -0.257, 
      p < .001), serum insulin (WMD = -2.036, 95% CI: -2.857, -1.216, p < .001), 
      homeostasis model assessment insulin resistance (HOMA-IR) (WMD = -0.886, 95% CI: 
      -1.375, -0.398, p < .001), high density lipoprotein-cholesterol (HDL-C) (WMD = 
      0.850, 95% CI: 0.018, 1.682, p = .045), triglyceride (TG) (WMD = -17.636, 95% CI: 
      -27.121, -8.151, p < .001), diastolic blood pressure (DBP) (WMD = -0.642, 95% CI: 
      -1.148, -0.137, p = .013), C-reactive protein (CRP) (WMD = -0.623, 95% CI: 
      -1.061, -0.186, p = .005), tumor necrosis factor-alpha (TNF-alpha) (WMD = -3.020, 95% CI: 
      -4.327, -1.712, p < .001), and interleukin 6 (IL-6) (WMD = -1.147, 95% CI: 
      -1.887, -0.406, p = .002). The supplementation of Zingiberaceae may be an 
      effective adjunctive therapy in management of T2DM and prevention cardiovascular 
      complications by decreasing BW, improving blood glucose control, insulin 
      resistance, lipid profiles (HDL-C and TG), blood pressure (DBP), and reducing 
      inflammation (CRP, TNF-alpha, and IL-6). PRACTICAL APPLICATIONS: Approximately half 
      of the deaths of individuals with diabetes mellitus (DM) are attributable to 
      cardiovascular disease (CVD), and individuals with T2DM have a two-fold increased 
      risk of cardiovascular mortality than healthy individuals. Currently, T2DM is 
      mainly treated with hypoglycemic medication such as sulfonylureas, 
      thiazolidinediones, meglitinides, and biguanides. Nevertheless, most of them with 
      long-term usage could cause side effects, including hypoglycemia and 
      gastrointestinal troubles. Several species of the Zingiberaceae family are used 
      in traditional herbal medicines, which have been widely used in traditional and 
      complementary medicine. Proving the potential benefits of Zingiberaceae on T2DM 
      and its cardiovascular complications has positive clinical implications for the 
      use of this practical herb.
CI  - (c) 2022 Wiley Periodicals LLC.
FAU - Zhang, Xiaofeng
AU  - Zhang X
AD  - Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou 
      University, Zhengzhou, China.
FAU - Chen, Xiaoli
AU  - Chen X
AD  - Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou 
      University, Zhengzhou, China.
FAU - Tang, Yujun
AU  - Tang Y
AD  - Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou 
      University, Zhengzhou, China.
FAU - Guan, Xiaoxian
AU  - Guan X
AD  - Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou 
      University, Zhengzhou, China.
FAU - Deng, Jinlan
AU  - Deng J
AD  - Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou 
      University, Zhengzhou, China.
FAU - Fan, Jianming
AU  - Fan J
AUID- ORCID: 0000-0002-4961-3399
AD  - Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou 
      University, Zhengzhou, China.
LA  - eng
GR  - 152102310260/Henan Institute of Science and Technology/
GR  - 31372453/National Natural Science Foundation of China/
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20220325
PL  - United States
TA  - J Food Biochem
JT  - Journal of food biochemistry
JID - 7706045
RN  - 0 (Blood Glucose)
RN  - 0 (Cholesterol, HDL)
RN  - 0 (Interleukin-6)
RN  - 0 (Plant Preparations)
RN  - 0 (Triglycerides)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Blood Glucose
MH  - C-Reactive Protein/analysis/metabolism
MH  - Cholesterol, HDL
MH  - *Diabetes Mellitus, Type 2/complications/drug therapy
MH  - Heart Disease Risk Factors
MH  - Humans
MH  - *Insulin Resistance
MH  - Interleukin-6
MH  - *Plant Preparations/therapeutic use
MH  - Plants, Medicinal/chemistry
MH  - Randomized Controlled Trials as Topic
MH  - Triglycerides
MH  - Tumor Necrosis Factor-alpha
MH  - *Zingiberaceae/chemistry
OTO - NOTNLM
OT  - Zingiberaceae
OT  - cardiovascular risk
OT  - medical plants
OT  - meta-analysis
OT  - systematic review
OT  - type 2 diabetes mellitus
EDAT- 2022/03/26 06:00
MHDA- 2022/07/09 06:00
CRDT- 2022/03/25 05:38
PHST- 2022/03/06 00:00 [revised]
PHST- 2022/01/08 00:00 [received]
PHST- 2022/03/08 00:00 [accepted]
PHST- 2022/03/26 06:00 [pubmed]
PHST- 2022/07/09 06:00 [medline]
PHST- 2022/03/25 05:38 [entrez]
AID - 10.1111/jfbc.14130 [doi]
PST - ppublish
SO  - J Food Biochem. 2022 Jul;46(7):e14130. doi: 10.1111/jfbc.14130. Epub 2022 Mar 25.