PMID- 35334557
OWN - NLM
STAT- MEDLINE
DCOM- 20220330
LR  - 20220401
IS  - 1648-9144 (Electronic)
IS  - 1010-660X (Print)
IS  - 1010-660X (Linking)
VI  - 58
IP  - 3
DP  - 2022 Mar 4
TI  - De Novo Detrusor Underactivity and Other Urodynamic Findings after Radical 
      Prostatectomy: A Systematic Review.
LID - 10.3390/medicina58030381 [doi]
LID - 381
AB  - Background and objectives: The aim of this systematic review is to evaluate the 
      impact of radical prostatectomy (RP) on bladder function, with special attention 
      towards detrusor underactivity investigated with the means of urodynamic 
      evaluation. Materials and Methods: The review was performed in accordance with 
      the PRISMA statement and was registered in the PROSPERO (ID#: CRD42020223480). 
      The studied population was limited to men with prostate cancer who underwent 
      urodynamic study prior to and after radical prostatectomy. Eight hundred 
      twenty-seven studies were screened, with twenty-five finally included. A 
      qualitative analysis was performed. Rates of detrusor underactivity (DU) before 
      surgery were reported in eight studies and ranged from 1.6% to 75% (median of 
      40.8%). DU occurred de novo after RP in 9.1% to 37% of patients (median of 
      29.1%). On the other hand, preexisting DU resolved in 7% to 35.5% of affected 
      men. Detrusor overactivity (DO) was the most frequently reported outcome, being 
      assessed in 23 studies. The rate of DO preoperatively was from 5% to 76% (median 
      of 25%). De novo was reported in 2.3-54.4% of patients (median of 15%) and 
      resolved after RP in 19.6% to 87.5% (median of 33%) of affected patients. 
      Baseline rates of bladder outlet obstruction (BOO) varied between studies from 
      19% to 59.3%, with a median of 27.8%. The most pronounced change after surgery 
      was the resolution of BOO in 88% to 93.8% (median of 92%) of affected patients. 
      Results: Rates of de novo impaired bladder compliance (IBC) varied from 3.2% to 
      41.3% (median of 13.3%), whereas the resolution of IBC was reported with rates 
      ranging from 0% to 47% (median of 4.8%). Conclusions: BOO, DO, and DU are 
      frequently diagnosed in men scheduled for RP. BOO is improved after RP in most 
      patients; however, there is still a substantial rate of patients with de novo DU 
      as well as DO which may impair functional outcomes and quality of life.
FAU - Oszczudlowski, Maciej
AU  - Oszczudlowski M
AD  - Urology Clinic, Centre of Postgraduate Medical Education, 01-813 Warsaw, Poland.
FAU - Bilski, Konrad
AU  - Bilski K
AD  - Urology Clinic, Centre of Postgraduate Medical Education, 01-813 Warsaw, Poland.
FAU - Kozikowski, Mieszko
AU  - Kozikowski M
AD  - Urology Clinic, Centre of Postgraduate Medical Education, 01-813 Warsaw, Poland.
FAU - Dobruch, Jakub
AU  - Dobruch J
AD  - Urology Clinic, Centre of Postgraduate Medical Education, 01-813 Warsaw, Poland.
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
DEP - 20220304
PL  - Switzerland
TA  - Medicina (Kaunas)
JT  - Medicina (Kaunas, Lithuania)
JID - 9425208
SB  - IM
MH  - Humans
MH  - Male
MH  - Prostatectomy/adverse effects
MH  - Quality of Life
MH  - Retrospective Studies
MH  - *Urinary Bladder, Underactive/diagnosis
MH  - *Urodynamics
PMC - PMC8949898
OTO - NOTNLM
OT  - bladder outlet obstruction
OT  - detrusor overactivity
OT  - detrusor underactivity
OT  - impaired bladder compliance
OT  - radical prostatectomy
OT  - urodynamic study
COIS- The authors declare no conflict of interest.
EDAT- 2022/03/27 06:00
MHDA- 2022/03/31 06:00
PMCR- 2022/03/04
CRDT- 2022/03/26 01:00
PHST- 2022/01/09 00:00 [received]
PHST- 2022/02/28 00:00 [revised]
PHST- 2022/03/01 00:00 [accepted]
PHST- 2022/03/26 01:00 [entrez]
PHST- 2022/03/27 06:00 [pubmed]
PHST- 2022/03/31 06:00 [medline]
PHST- 2022/03/04 00:00 [pmc-release]
AID - medicina58030381 [pii]
AID - medicina-58-00381 [pii]
AID - 10.3390/medicina58030381 [doi]
PST - epublish
SO  - Medicina (Kaunas). 2022 Mar 4;58(3):381. doi: 10.3390/medicina58030381.