PMID- 35334602
OWN - NLM
STAT- MEDLINE
DCOM- 20220331
LR  - 20220401
IS  - 1648-9144 (Electronic)
IS  - 1010-660X (Print)
IS  - 1010-660X (Linking)
VI  - 58
IP  - 3
DP  - 2022 Mar 15
TI  - Long-Term Follow-Up of Survivors of Extracorporeal Life Support Therapy for 
      Cardiogenic Shock: Are They Really Survivors?
LID - 10.3390/medicina58030427 [doi]
LID - 427
AB  - Background and Objectives: Cardiogenic shock (CS) is a medical emergency 
      associated with a high mortality rate. Veno-arterial extracorporeal membrane 
      oxygenation (VA-ECMO) has become an accepted therapy for CS. Despite widely 
      available data for short-term survival rates, there are only limited data 
      available regarding long-term outcomes following successful VA-ECMO therapy. 
      Materials and Methods: We analyzed the demographics, past medical history, 
      adverse events, and outcomes of survivors who received VA-ECMO support for CS at 
      our center from January 2012 to December 2019. Post-cardiotomy cases were 
      excluded. Results: A total of 578 VA-ECMO implantations on 564 consecutive 
      patients due to CS were identified during the study period. Successful weaning 
      was achieved in 207 (36.7%) patients. Among the survivors, 126 (63%) patients 
      received VA-ECMO therapy without preceding cardiac surgery during their current 
      admission. A follow-up exceeding 12 (mean: 36 +/- 20.9) months was available in a 
      total of 55 (43.7%) survivors. The mean VA-ECMO perfusion time was 10.9 (+/-7.7) 
      days with a mean intensive care unit (ICU) stay of 38.2 (+/-29.9) days and a mean 
      hospital stay of 49.9 (+/-30.5) days. A total of 3 deaths were recorded during 
      long-term follow-up (mean survival of 26 +/- 5.3 months). Conclusions: Despite the 
      high mortality associated with VA-ECMO therapy, a long-term follow-up with an 
      acceptably low rate of negative cardiac events can be achieved in many survivors. 
      We observed an acceptable low rate of new cardiac events. Further evaluation, 
      including a quality-of-life assessment and a close follow-up for rarer 
      complications in these patients, is needed to elucidate the longer-term outcomes 
      for survivors of invasive VA-ECMO therapy.
FAU - Berger, Rafal
AU  - Berger R
AUID- ORCID: 0000-0002-8245-4457
AD  - Department of Thoracic and Cardiovascular Surgery, University Hospital Tubingen, 
      72076 Tubingen, Germany.
FAU - Nemeth, Attila
AU  - Nemeth A
AD  - Department of Thoracic and Cardiovascular Surgery, University Hospital Tubingen, 
      72076 Tubingen, Germany.
FAU - Sandoval Boburg, Rodrigo
AU  - Sandoval Boburg R
AUID- ORCID: 0000-0002-4907-7020
AD  - Department of Thoracic and Cardiovascular Surgery, University Hospital Tubingen, 
      72076 Tubingen, Germany.
FAU - Vohringer, Louise
AU  - Vohringer L
AD  - Department of Thoracic and Cardiovascular Surgery, University Hospital Tubingen, 
      72076 Tubingen, Germany.
FAU - Lausberg, Henning Florian
AU  - Lausberg HF
AD  - Department of Thoracic and Cardiovascular Surgery, Saarland University Medical 
      Center, 66421 Homburg, Germany.
FAU - Acharya, Metesh
AU  - Acharya M
AD  - Department of Cardiac Surgery, Glenfield Hospital, Leicester LE3 9QP, UK.
FAU - Schlensak, Christian
AU  - Schlensak C
AD  - Department of Thoracic and Cardiovascular Surgery, University Hospital Tubingen, 
      72076 Tubingen, Germany.
FAU - Popov, Aron-Frederik
AU  - Popov AF
AUID- ORCID: 0000-0003-4226-3004
AD  - Department of Thoracic and Cardiovascular Surgery, University Hospital Tubingen, 
      72076 Tubingen, Germany.
AD  - Department of Cardiac Surgery, Helios Heart Center Siegburg, 53721 Siegburg, 
      Germany.
LA  - eng
PT  - Journal Article
DEP - 20220315
PL  - Switzerland
TA  - Medicina (Kaunas)
JT  - Medicina (Kaunas, Lithuania)
JID - 9425208
SB  - IM
MH  - *Extracorporeal Membrane Oxygenation
MH  - Follow-Up Studies
MH  - Humans
MH  - Retrospective Studies
MH  - Shock, Cardiogenic/etiology/therapy
MH  - Survivors
PMC - PMC8948741
OTO - NOTNLM
OT  - cardiogenic shock
OT  - extracorporeal membrane oxygenation
OT  - long-term follow-up
COIS- The authors declare no conflict of interest.
EDAT- 2022/03/27 06:00
MHDA- 2022/04/01 06:00
PMCR- 2022/03/15
CRDT- 2022/03/26 01:00
PHST- 2022/01/30 00:00 [received]
PHST- 2022/02/24 00:00 [revised]
PHST- 2022/03/14 00:00 [accepted]
PHST- 2022/03/26 01:00 [entrez]
PHST- 2022/03/27 06:00 [pubmed]
PHST- 2022/04/01 06:00 [medline]
PHST- 2022/03/15 00:00 [pmc-release]
AID - medicina58030427 [pii]
AID - medicina-58-00427 [pii]
AID - 10.3390/medicina58030427 [doi]
PST - epublish
SO  - Medicina (Kaunas). 2022 Mar 15;58(3):427. doi: 10.3390/medicina58030427.