PMID- 35334606
OWN - NLM
STAT- MEDLINE
DCOM- 20220330
LR  - 20230721
IS  - 1648-9144 (Electronic)
IS  - 1010-660X (Print)
IS  - 1010-660X (Linking)
VI  - 58
IP  - 3
DP  - 2022 Mar 16
TI  - Metformin: Sex/Gender Differences in Its Uses and Effects-Narrative Review.
LID - 10.3390/medicina58030430 [doi]
LID - 430
AB  - Metformin (MTF) occupies a major and fundamental position in the therapeutic 
      management of type 2 diabetes mellitus (T2DM). Gender differences in some effects 
      and actions of MTF have been reported. Women are usually prescribed lower MTF 
      doses compared to men and report more gastrointestinal side effects. The 
      incidence of cardiovascular events in women on MTF has been found to be lower to 
      that of men on MTF. Despite some promising results with MTF regarding pregnancy 
      rates in women with PCOS, the management of gestational diabetes, cancer 
      prevention or adjunctive cancer treatment and COVID-19, most robust meta-analyses 
      have yet to confirm such beneficial effects.
FAU - Ilias, Ioannis
AU  - Ilias I
AUID- ORCID: 0000-0001-5718-7441
AD  - Department of Endocrinology, Diabetes and Metabolism, Elena Venizelou Hospital, 
      GR-11521 Athens, Greece.
FAU - Rizzo, Manfredi
AU  - Rizzo M
AUID- ORCID: 0000-0002-9549-8504
AD  - Department of Health Promotion Sciences, Maternal and Infantile Care, Internal 
      Medicine and Medical Specialties (Promise), School of Medicine, University of 
      Palermo, Via del Vespro, 141, 90127 Palermo, Italy.
FAU - Zabuliene, Lina
AU  - Zabuliene L
AD  - Faculty of Medicine, Vilnius University, M. K. Ciurlionio St. 21/27, LT-03101 
      Vilnius, Lithuania.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220316
PL  - Switzerland
TA  - Medicina (Kaunas)
JT  - Medicina (Kaunas, Lithuania)
JID - 9425208
RN  - 0 (Hypoglycemic Agents)
RN  - 9100L32L2N (Metformin)
SB  - IM
MH  - *Diabetes Mellitus, Type 2/complications/drug therapy
MH  - Female
MH  - Humans
MH  - Hypoglycemic Agents/adverse effects
MH  - Male
MH  - *Metformin/pharmacology/therapeutic use
MH  - *Polycystic Ovary Syndrome
MH  - Pregnancy
MH  - Sex Factors
MH  - *COVID-19 Drug Treatment
PMC - PMC8952223
OTO - NOTNLM
OT  - Metformin
OT  - gender
OT  - insulin resistance
COIS- The authors declare that they have no conflict of interest.
EDAT- 2022/03/27 06:00
MHDA- 2022/03/31 06:00
PMCR- 2022/03/16
CRDT- 2022/03/26 01:00
PHST- 2022/02/14 00:00 [received]
PHST- 2022/03/08 00:00 [revised]
PHST- 2022/03/14 00:00 [accepted]
PHST- 2022/03/26 01:00 [entrez]
PHST- 2022/03/27 06:00 [pubmed]
PHST- 2022/03/31 06:00 [medline]
PHST- 2022/03/16 00:00 [pmc-release]
AID - medicina58030430 [pii]
AID - medicina-58-00430 [pii]
AID - 10.3390/medicina58030430 [doi]
PST - epublish
SO  - Medicina (Kaunas). 2022 Mar 16;58(3):430. doi: 10.3390/medicina58030430.