PMID- 35334913
OWN - NLM
STAT- MEDLINE
DCOM- 20220330
LR  - 20220401
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 14
IP  - 6
DP  - 2022 Mar 16
TI  - Effect of Chronic Moderate Caloric Restriction on the Reproductive Function in 
      Aged Male Wistar Rats.
LID - 10.3390/nu14061256 [doi]
LID - 1256
AB  - Caloric restriction (CR) has been shown to be an effective nutritional 
      intervention for increasing longevity in some animal species. The objective of 
      this study was to evaluate CR's effects on metabolic and reproductive parameters 
      in 12-month-old male Wistar rats. The rats were distributed in three groups: 
      control, CR at 15%, and CR at 35% for 6 (up to 18 months of age) and 12 months 
      (up to 24 months of age). At the end of CR treatment, we evaluated reproductive 
      (male sexual behavior (MSB), sperm quality) and biochemical parameters (plasma 
      glucose, glucose-regulating hormone, and sex steroid levels), and quantified 
      annexin V in the seminiferous epithelium. Results showed that MSB and sperm 
      quality were improved after 6 months of CR associated with increases in plasma 
      testosterone and decrease annexin V in the seminiferous epithelium of the 
      testicles compared to their control group. The metabolic profile of the CR rats 
      also improved compared to controls. However, these effects of CR on reproductive 
      parameters were not maintained after 12 months of CR. Findings suggest that 
      beginning CR at the age of maturity reestablishes the behavioral sexual response 
      and reproductive function in older animals after 6 months of CR and improves 
      endocrine functioning during aging.
FAU - Jesus, Pablo Lopez de
AU  - Jesus PL
AD  - Doctorado en Ciencias Biologicas y de la Salud, Universidad Autonoma 
      Metropolitana, Ciudad de Mexico 09340, Mexico.
FAU - Arenas-Rios, Edith
AU  - Arenas-Rios E
AUID- ORCID: 0000-0002-2534-9351
AD  - Departamento de Biologia de la Reproduccion, Universidad Autonoma 
      Metropolitana-Iztapalapa, Ciudad de Mexico 09340, Mexico.
FAU - Ruiz-Ramos, Mirna
AU  - Ruiz-Ramos M
AD  - Unidad de Investigacion en Gerontologia, Facultad de Estudios Superiores 
      Zaragoza, Universidad Nacional Autonoma de Mexico, Ciudad de Mexico 09230, 
      Mexico.
FAU - Flores-Alonso, Juan Carlos
AU  - Flores-Alonso JC
AD  - Centro de Investigacion Biomedica de Oriente, Instituto Mexicano del Seguro 
      Social, Hospital General de Zona No. 5, Puebla 74360, Mexico.
FAU - Mendoza-Nunez, Victor Manuel
AU  - Mendoza-Nunez VM
AUID- ORCID: 0000-0002-9137-3405
AD  - Unidad de Investigacion en Gerontologia, Facultad de Estudios Superiores 
      Zaragoza, Universidad Nacional Autonoma de Mexico, Ciudad de Mexico 09230, 
      Mexico.
FAU - Arrieta-Cruz, Isabel
AU  - Arrieta-Cruz I
AD  - Departamento de Investigacion Basica, Instituto Nacional de Geriatria, Secretaria 
      de Salud, Ciudad de Mexico 10200, Mexico.
FAU - Arteaga-Silva, Marcela
AU  - Arteaga-Silva M
AUID- ORCID: 0000-0002-6792-2187
AD  - Departamento de Biologia de la Reproduccion, Universidad Autonoma 
      Metropolitana-Iztapalapa, Ciudad de Mexico 09340, Mexico.
LA  - eng
GR  - CVU Becario: 718777/Consejo Nacional de Ciencia y Tecnologia/
PT  - Journal Article
DEP - 20220316
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 3XMK78S47O (Testosterone)
SB  - IM
MH  - Aging/physiology
MH  - Animals
MH  - *Caloric Restriction
MH  - *Longevity
MH  - Male
MH  - Rats
MH  - Rats, Wistar
MH  - Testosterone
PMC - PMC8952234
OTO - NOTNLM
OT  - calorie restriction
OT  - male sexual behavior
OT  - seminiferous tubules
OT  - testis
OT  - testosterone
COIS- The authors declare no conflict of interest.
EDAT- 2022/03/27 06:00
MHDA- 2022/03/31 06:00
PMCR- 2022/03/16
CRDT- 2022/03/26 01:01
PHST- 2022/01/03 00:00 [received]
PHST- 2022/03/02 00:00 [revised]
PHST- 2022/03/14 00:00 [accepted]
PHST- 2022/03/26 01:01 [entrez]
PHST- 2022/03/27 06:00 [pubmed]
PHST- 2022/03/31 06:00 [medline]
PHST- 2022/03/16 00:00 [pmc-release]
AID - nu14061256 [pii]
AID - nutrients-14-01256 [pii]
AID - 10.3390/nu14061256 [doi]
PST - epublish
SO  - Nutrients. 2022 Mar 16;14(6):1256. doi: 10.3390/nu14061256.