PMID- 35334956 OWN - NLM STAT- MEDLINE DCOM- 20220330 LR - 20230308 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 14 IP - 6 DP - 2022 Mar 18 TI - Oxidative Stress and Left Ventricular Performance in Patients with Different Glycometabolic Phenotypes. LID - 10.3390/nu14061299 [doi] LID - 1299 AB - The aim of the present study was to evaluate the possible correlation between oxidative stress and subclinical myocardial damage, assessed with speckle tracking echocardiography (STE), in normal glucose tolerance (NGT) patients with one-hour plasma glucose values >/= 155 mg/dL (NGT >/= 155), comparing them to NGT < 155 subjects, impaired glucose tolerance (IGT) and type 2 diabetes mellitus (T2DM) newly diagnosed patients. We enrolled 100 Caucasian patients. All subjects underwent OGTT. The serum values of oxidative stress markers (8-isoprostane and Nox-2) were assessed with an ELISA test. Echocardiographic recordings were performed using an E-95 Pro ultrasound system. We observed significant differences, among the four groups, for fasting plasma glucose (p < 0.0001), one-hour postload (p < 0.0001), and two-hour postload plasma glucose (p < 0.0001). As compared with NGT < 155, NGT >/= 155 exhibited significantly worse insulin sensitivity and higher values of hs-CRP. No significant differences were observed between NGT >/= 155 and IGT patients. There was a significant increase in 8-isoprostane (p < 0.0001) and Nox-2 (p < 0.0001), from the first to fourth group, indicating an increase in oxidative stress with the worsening of the metabolic status. Serum levels of 8-isoprostane and Nox-2 were significantly increased in NGT >/= 155 compared to the NGT < 155 group, but similar to IGT. The global longitudinal strain (GLS) appeared progressively lower proceeding from the NGT < 155 to T2DM group (p < 0.0001). For similar values of left ventricular ejection fraction (LVEF), NGT >/= 155 exhibited reduced GLS compared to NGT < 155 (p = 0.001), but similar to IGT patients. Our study demonstrated that NGT >/= 155 subjects exhibit early functional impairment of myocardial contractile fibres, these alterations are correlated with increased oxidative stress. FAU - Cassano, Velia AU - Cassano V AUID- ORCID: 0000-0002-0793-1225 AD - Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy. FAU - Miceli, Sofia AU - Miceli S AD - Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy. FAU - Armentaro, Giuseppe AU - Armentaro G AUID- ORCID: 0000-0001-9775-9715 AD - Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy. FAU - Mannino, Gaia Chiara AU - Mannino GC AUID- ORCID: 0000-0002-6341-4572 AD - Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy. FAU - Fiorentino, Vanessa Teresa AU - Fiorentino VT AD - Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy. FAU - Perticone, Maria AU - Perticone M AD - Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy. FAU - Succurro, Elena AU - Succurro E AUID- ORCID: 0000-0003-2578-692X AD - Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy. AD - Research Center for the Prevention and Treatment of Metabolic Diseases, University of Catanzaro, 88100 Catanzaro, Italy. FAU - Hribal, Marta Letizia AU - Hribal ML AUID- ORCID: 0000-0001-5932-0541 AD - Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy. AD - Research Center for the Prevention and Treatment of Metabolic Diseases, University of Catanzaro, 88100 Catanzaro, Italy. FAU - Andreozzi, Francesco AU - Andreozzi F AUID- ORCID: 0000-0001-9375-1513 AD - Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy. AD - Research Center for the Prevention and Treatment of Metabolic Diseases, University of Catanzaro, 88100 Catanzaro, Italy. FAU - Perticone, Francesco AU - Perticone F AUID- ORCID: 0000-0003-2402-0981 AD - Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy. FAU - Sesti, Giorgio AU - Sesti G AUID- ORCID: 0000-0002-1618-7688 AD - Department of Clinical and Molecular Medicine, University Rome-Sapienza, 00185 Roma, Italy. FAU - Sciacqua, Angela AU - Sciacqua A AD - Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy. AD - Research Center for the Prevention and Treatment of Metabolic Diseases, University of Catanzaro, 88100 Catanzaro, Italy. LA - eng PT - Journal Article DEP - 20220318 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Blood Glucose) SB - IM MH - Blood Glucose/metabolism MH - *Diabetes Mellitus, Type 2 MH - Glucose Tolerance Test MH - Humans MH - Oxidative Stress MH - Phenotype MH - Stroke Volume MH - Ventricular Function, Left PMC - PMC8950717 OTO - NOTNLM OT - global longitudinal strain OT - hyperglycaemia OT - organ damage OT - oxidative stress OT - type 2 diabetes COIS- The authors declare that they have no competing interests. EDAT- 2022/03/27 06:00 MHDA- 2022/03/31 06:00 PMCR- 2022/03/18 CRDT- 2022/03/26 01:01 PHST- 2022/02/22 00:00 [received] PHST- 2022/03/15 00:00 [revised] PHST- 2022/03/17 00:00 [accepted] PHST- 2022/03/26 01:01 [entrez] PHST- 2022/03/27 06:00 [pubmed] PHST- 2022/03/31 06:00 [medline] PHST- 2022/03/18 00:00 [pmc-release] AID - nu14061299 [pii] AID - nutrients-14-01299 [pii] AID - 10.3390/nu14061299 [doi] PST - epublish SO - Nutrients. 2022 Mar 18;14(6):1299. doi: 10.3390/nu14061299.