PMID- 35335138
OWN - NLM
STAT- MEDLINE
DCOM- 20220330
LR  - 20220401
IS  - 1420-3049 (Electronic)
IS  - 1420-3049 (Linking)
VI  - 27
IP  - 6
DP  - 2022 Mar 8
TI  - Recent Advances in Glycyrrhetinic Acid-Functionalized Biomaterials for Liver 
      Cancer-Targeting Therapy.
LID - 10.3390/molecules27061775 [doi]
LID - 1775
AB  - Liver cancer is one of the most common causes of cancer mortality worldwide. 
      Chemotherapy and radiotherapy are the conventional therapies generally employed 
      in patients with liver tumors. The major issue associated with the administration 
      of chemotherapeutics is their high toxicity and lack of selectivity, leading to 
      systemic toxicity that can be detrimental to the patient's quality of life. An 
      important approach to the development of original liver-targeted therapeutic 
      products takes advantage of the employment of biologically active ligands able to 
      bind specific receptors on the cytoplasmatic membranes of liver cells. In this 
      perspective, glycyrrhetinic acid (GA), a pentacyclic triterpenoid present in 
      roots and rhizomes of licorice, has been used as a ligand for targeting the liver 
      due to the expression of GA receptors on the sinusoidal surface of mammalian 
      hepatocytes, so it may be employed to modify drug delivery systems (DDSs) and 
      obtain better liver or hepatocyte drug uptake and efficacy. In the current 
      review, we focus on the most recent and interesting research advances in the 
      development of GA-based hybrid compounds and DDSs developed for potential 
      employment as efficacious therapeutic options for the treatment of hepatic 
      cancer.
FAU - Speciale, Antonio
AU  - Speciale A
AUID- ORCID: 0000-0002-6135-3892
AD  - Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, 
      University of Messina, Viale Ferdinando Stagno D'Alcontres 31, 98166 Messina, 
      Italy.
FAU - Muscara, Claudia
AU  - Muscara C
AUID- ORCID: 0000-0003-1815-1731
AD  - Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, 
      University of Messina, Viale Ferdinando Stagno D'Alcontres 31, 98166 Messina, 
      Italy.
FAU - Molonia, Maria Sofia
AU  - Molonia MS
AUID- ORCID: 0000-0001-8841-589X
AD  - Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, 
      University of Messina, Viale Ferdinando Stagno D'Alcontres 31, 98166 Messina, 
      Italy.
FAU - Cristani, Mariateresa
AU  - Cristani M
AD  - Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, 
      University of Messina, Viale Ferdinando Stagno D'Alcontres 31, 98166 Messina, 
      Italy.
FAU - Cimino, Francesco
AU  - Cimino F
AUID- ORCID: 0000-0002-8954-4797
AD  - Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, 
      University of Messina, Viale Ferdinando Stagno D'Alcontres 31, 98166 Messina, 
      Italy.
FAU - Saija, Antonella
AU  - Saija A
AUID- ORCID: 0000-0002-4186-3596
AD  - Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, 
      University of Messina, Viale Ferdinando Stagno D'Alcontres 31, 98166 Messina, 
      Italy.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220308
PL  - Switzerland
TA  - Molecules
JT  - Molecules (Basel, Switzerland)
JID - 100964009
RN  - 0 (Biocompatible Materials)
RN  - P540XA09DR (Glycyrrhetinic Acid)
SB  - IM
MH  - Animals
MH  - Biocompatible Materials/therapeutic use
MH  - *Glycyrrhetinic Acid
MH  - Humans
MH  - *Liver Neoplasms/drug therapy/metabolism
MH  - Mammals
MH  - Quality of Life
PMC - PMC8954912
OTO - NOTNLM
OT  - drug delivery systems
OT  - glycyrrhetinic acid
OT  - liver cancer
OT  - liver targeting
COIS- The authors declare no conflict of interest.
EDAT- 2022/03/27 06:00
MHDA- 2022/03/31 06:00
PMCR- 2022/03/08
CRDT- 2022/03/26 01:02
PHST- 2022/02/05 00:00 [received]
PHST- 2022/03/04 00:00 [revised]
PHST- 2022/03/06 00:00 [accepted]
PHST- 2022/03/26 01:02 [entrez]
PHST- 2022/03/27 06:00 [pubmed]
PHST- 2022/03/31 06:00 [medline]
PHST- 2022/03/08 00:00 [pmc-release]
AID - molecules27061775 [pii]
AID - molecules-27-01775 [pii]
AID - 10.3390/molecules27061775 [doi]
PST - epublish
SO  - Molecules. 2022 Mar 8;27(6):1775. doi: 10.3390/molecules27061775.