PMID- 35335262
OWN - NLM
STAT- MEDLINE
DCOM- 20220330
LR  - 20220401
IS  - 1420-3049 (Electronic)
IS  - 1420-3049 (Linking)
VI  - 27
IP  - 6
DP  - 2022 Mar 15
TI  - Laurus nobilis L. Essential Oil-Loaded PLGA as a Nanoformulation Candidate for 
      Cancer Treatment.
LID - 10.3390/molecules27061899 [doi]
LID - 1899
AB  - The aim of this study was to obtain essential oil (LNEO) from the Laurus nobilis 
      L. plant, and to prepare LNEO-loaded poly lactic-co-glycolic acid (PLGA) 
      nanoparticles (NPs) as an approach in cancer treatment. The components of the 
      obtained LNEO were analyzed using GC-MS. The LNEO-NPs were synthesized by the 
      single-emulsion method. The LNEO-NPs were characterized using UV-Vis 
      spectrometry, Dynamic Light Scattering (DLS), Scanning Electron Microscopy (SEM), 
      and a DNA binding assay, which was performed via the UV-Vis titration method. 
      According to the results, the LNEO-NPs had a 211.4 +/- 4.031 nm average particle 
      size, 0.068 +/- 0.016 PdI, and -7.87 +/- 1.15 mV zeta potential. The encapsulation 
      efficiency and loading capacity were calculated as 59.25% and 25.65%, 
      respectively, and the in vitro drug release study showed an LNEO release of 93.97 
      +/- 3.78% over the 72 h period. Moreover, the LNEO was intercalatively bound to 
      CT-DNA. In addition, the mechanism of action of LNEO on a dual PI3K/mTOR 
      inhibitor was predicted, and its antiproliferative activity and mechanism were 
      determined using molecular docking analysis. It was concluded that LNEO-loaded 
      PLGA NPs may be used for cancer treatment as a novel phytotherapeutic agent-based 
      controlled-release system.
FAU - Ercin, Esin
AU  - Ercin E
AD  - Department of Pharmacognosy and Natural Product Chemistry, Institute of Health 
      Sciences, Bezmialem Vakif University, Istanbul 34093, Turkey.
FAU - Kecel-Gunduz, Serda
AU  - Kecel-Gunduz S
AUID- ORCID: 0000-0003-0973-8223
AD  - Department of Physics, Faculty of Science, Istanbul University, Istanbul 34134, 
      Turkey.
FAU - Gok, Bahar
AU  - Gok B
AUID- ORCID: 0000-0001-9499-1420
AD  - Department of Bioengineering, Graduate School of Natural and Applied Science, 
      Yildiz Technical University, Istanbul 34220, Turkey.
FAU - Aydin, Tugba
AU  - Aydin T
AD  - Department of Pharmacognosy and Natural Product Chemistry, Institute of Health 
      Sciences, Bezmialem Vakif University, Istanbul 34093, Turkey.
AD  - Department of Pharmacognosy, Faculty of Pharmacy, Istinye University, Istanbul 
      34010, Turkey.
FAU - Budama-Kilinc, Yasemin
AU  - Budama-Kilinc Y
AD  - Department of Bioengineering, Faculty of Chemical and Metallurgical Engineering, 
      Yildiz Technical University, Istanbul 34220, Turkey.
FAU - Kartal, Murat
AU  - Kartal M
AD  - Department of Pharmacognosy, Faculty of Pharmacy, Bezmialem Vakif University, 
      Istanbul 34093, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20220315
PL  - Switzerland
TA  - Molecules
JT  - Molecules (Basel, Switzerland)
JID - 100964009
RN  - 0 (Glycols)
RN  - 0 (Oils, Volatile)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 26009-03-0 (Polyglycolic Acid)
RN  - 33X04XA5AT (Lactic Acid)
SB  - IM
MH  - Glycols
MH  - Lactic Acid/chemistry
MH  - *Laurus
MH  - Molecular Docking Simulation
MH  - *Neoplasms/drug therapy
MH  - *Oils, Volatile/pharmacology
MH  - Polyglycolic Acid/chemistry
MH  - Polylactic Acid-Polyglycolic Acid Copolymer/chemistry
PMC - PMC8951774
OTO - NOTNLM
OT  - DNA binding
OT  - PLGA
OT  - controlled release system
OT  - laurel essential oil
OT  - nanoparticle
COIS- The authors declare no conflict of interest.
EDAT- 2022/03/27 06:00
MHDA- 2022/03/31 06:00
PMCR- 2022/03/15
CRDT- 2022/03/26 01:02
PHST- 2022/02/09 00:00 [received]
PHST- 2022/03/10 00:00 [revised]
PHST- 2022/03/10 00:00 [accepted]
PHST- 2022/03/26 01:02 [entrez]
PHST- 2022/03/27 06:00 [pubmed]
PHST- 2022/03/31 06:00 [medline]
PHST- 2022/03/15 00:00 [pmc-release]
AID - molecules27061899 [pii]
AID - molecules-27-01899 [pii]
AID - 10.3390/molecules27061899 [doi]
PST - epublish
SO  - Molecules. 2022 Mar 15;27(6):1899. doi: 10.3390/molecules27061899.