PMID- 35335637
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220329
IS  - 2076-0817 (Print)
IS  - 2076-0817 (Electronic)
IS  - 2076-0817 (Linking)
VI  - 11
IP  - 3
DP  - 2022 Mar 3
TI  - Incidence, Persistence, and Clearance of Anal Human Papillomavirus among Men Who 
      Have Sex with Men in China: An Observational Cohort Study.
LID - 10.3390/pathogens11030314 [doi]
LID - 314
AB  - (1) Background: We conducted a prospective observational cohort study to measure 
      incidence, persistence, and clearance of anal human papillomavirus (HPV) among 
      men who have sex with men (MSM) in China. (2) Methods: MSM were recruited in 
      Guangzhou, Shenzhen and Wuxi, China in 2017. A tablet-based questionnaire was 
      used to collect sociodemographic and behavioral characteristics. An anal brush 
      sample was collected for HPV testing and genotyping. Participants were followed 
      up 12 months after enrolment. (3) Results: A total of 196 participants completed 
      two HPV tests with a median age of 27.3 (interquartile range (IQR) 24.0-32.8) 
      years. Rate of incidence, persistence, and clearance for HPV among MSM were 31.3 
      (95% confidence interval (CI) 24.7-39.2), 47.9 (36.8-61.3), and 122.5 
      (104.3-143.0) per 1000 person months (pm), respectively. HPV 16 (4.1/1000 pm) had 
      the highest incidence rate, and HPV 6 (47.4/1000 pm) had the highest persistence 
      rate. Having lower education and engaging in receptive anal intercourse were 
      potential risk factors of HPV incidence. A higher incidence rate was observed 
      among younger MSM. (4) Conclusions: The high incidence and low clearance of anal 
      HPV highlight the necessity of HPV vaccination among MSM. Further studies are 
      needed to clarify the HPV dynamics at multiple anatomical sites and the burden of 
      HPV-related diseases among MSM.
FAU - Zhou, Yiguo
AU  - Zhou Y
AUID- ORCID: 0000-0002-2172-4396
AD  - School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen 518107, 
      China.
FAU - Zhou, Xinyi
AU  - Zhou X
AD  - School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen 518107, 
      China.
FAU - Lin, Yi-Fan
AU  - Lin YF
AD  - School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen 518107, 
      China.
FAU - Luo, Ganfeng
AU  - Luo G
AD  - School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen 518107, 
      China.
FAU - Lu, Yong
AU  - Lu Y
AD  - School of Public Health, Sun Yat-sen University, Guangzhou 510006, China.
AD  - School of Public Health, Guizhou Medical University, Guiyang 550025, China.
FAU - Wang, Zhenyu
AU  - Wang Z
AD  - School of Public Health, Sun Yat-sen University, Guangzhou 510006, China.
FAU - Li, Peiyang
AU  - Li P
AD  - School of Public Health, Sun Yat-sen University, Guangzhou 510006, China.
FAU - Luo, Zhenzhou
AU  - Luo Z
AD  - Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen 518000, China.
FAU - Meng, Xiaojun
AU  - Meng X
AD  - Wuxi Municipal Centre for Disease Control and Prevention, Wuxi 214023, China.
FAU - Tian, Tian
AU  - Tian T
AD  - School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen 518107, 
      China.
FAU - Fu, Leiwen
AU  - Fu L
AD  - School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen 518107, 
      China.
FAU - Dai, Jianghong
AU  - Dai J
AD  - School of Public Health, Xinjiang Medical University, Urumqi 830011, China.
FAU - Zou, Huachun
AU  - Zou H
AUID- ORCID: 0000-0002-8161-7576
AD  - School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen 518107, 
      China.
AD  - Kirby Institute, University of New South Wales, Sydney, NSW 2052, Australia.
LA  - eng
GR  - 82022064/Natural Science Foundation of China Excellent Young Scientists Fund/
GR  - 72061137001/Natural Science Foundation of China International/Regional Research 
      Collaboration Project/
GR  - 2019TQ05Y230/Special Support Plan for High-Level Talents of Guangdong Province/
PT  - Journal Article
DEP - 20220303
PL  - Switzerland
TA  - Pathogens
JT  - Pathogens (Basel, Switzerland)
JID - 101596317
PMC - PMC8949987
OTO - NOTNLM
OT  - clearance
OT  - human papillomavirus
OT  - incidence
OT  - men who have sex with men
OT  - persistence
COIS- The authors declare no conflict of interest.
EDAT- 2022/03/27 06:00
MHDA- 2022/03/27 06:01
PMCR- 2022/03/03
CRDT- 2022/03/26 01:03
PHST- 2022/01/21 00:00 [received]
PHST- 2022/02/24 00:00 [revised]
PHST- 2022/03/01 00:00 [accepted]
PHST- 2022/03/26 01:03 [entrez]
PHST- 2022/03/27 06:00 [pubmed]
PHST- 2022/03/27 06:01 [medline]
PHST- 2022/03/03 00:00 [pmc-release]
AID - pathogens11030314 [pii]
AID - pathogens-11-00314 [pii]
AID - 10.3390/pathogens11030314 [doi]
PST - epublish
SO  - Pathogens. 2022 Mar 3;11(3):314. doi: 10.3390/pathogens11030314.