PMID- 35336226
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220329
IS  - 2076-2607 (Print)
IS  - 2076-2607 (Electronic)
IS  - 2076-2607 (Linking)
VI  - 10
IP  - 3
DP  - 2022 Mar 18
TI  - Virological Characterization of Pigs with Erythema Multiforme.
LID - 10.3390/microorganisms10030652 [doi]
LID - 652
AB  - Erythema multiforme in pigs is an acute, self-limiting disease characterized by 
      red skin areas and often associated with anorexia, fever and respiratory 
      problems. The cause of the disease remains unknown. In a recent study, animals of 
      a commercial breeding herd in Greece were examined, and all animals were found 
      seropositive for porcine reproductive and respiratory syndrome virus (PRRSV). 
      However, neither PRRSV and porcine circovirus type 2 (PCV2) viremia nor 
      antibodies against Aujeszky's disease virus, African swine fever virus and 
      classical swine fever virus were detected. Here, an extended examination of these 
      pigs was performed on a wide range of porcine viruses using highly sensitive 
      polymerase chain reaction (PCR)-based methods. Affected skin of five animals 
      revealed the presence of porcine lymphotropic herpesvirus-1 (PLHV-1) in all 
      cases, PLHV-2 in one animal and PLHV-3 in four animals. However, neither porcine 
      cytomegalovirus (PCMV) nor porcine circoviruses (PCV1, PCV2, PCV3 and PCV4) were 
      detected. In blood samples, PLHV-1 was present in two animals and PLHV-2, PCV2 
      and PCV3 in one individual, with PCMV, PCV1 and PCV4 in none of the animals. In 
      one animal, four viruses were found in the blood (PLHV-1, PLHV-2, PCV2 and PCV3). 
      A PRRSV viremia was also not detected. All animals carried porcine endogenous 
      retrovirus C (PERV-C) in their genome, but recombinant PERV-A/C was not detected. 
      The results suggest that porcine viruses may be involved in erythema multiforme 
      in these animals and that further studies are needed to assess the role of these 
      pathogens in the disease.
FAU - Halecker, Sabrina
AU  - Halecker S
AD  - Institute of Virology, Free University Berlin, 14163 Berlin, Germany.
FAU - Papatsiros, Vasileios
AU  - Papatsiros V
AUID- ORCID: 0000-0003-4955-0460
AD  - Clinic of Medicine (Porcine Medicine), Faculty of Veterinary Medicine, University 
      of Thessaly, GR 43100 Karditsa, Greece.
FAU - Psalla, Dimitra
AU  - Psalla D
AUID- ORCID: 0000-0002-1539-4124
AD  - Laboratory of Pathology, School of Veterinary Medicine, Aristotle University of 
      Thessaloniki, GR 54124 Thessaloniki, Greece.
FAU - Krabben, Ludwig
AU  - Krabben L
AD  - Institute of Virology, Free University Berlin, 14163 Berlin, Germany.
FAU - Kaufer, Benedikt
AU  - Kaufer B
AUID- ORCID: 0000-0003-1328-2695
AD  - Institute of Virology, Free University Berlin, 14163 Berlin, Germany.
FAU - Denner, Joachim
AU  - Denner J
AUID- ORCID: 0000-0003-3244-6085
AD  - Institute of Virology, Free University Berlin, 14163 Berlin, Germany.
LA  - eng
GR  - TRR127/German Research Foundation/
PT  - Journal Article
DEP - 20220318
PL  - Switzerland
TA  - Microorganisms
JT  - Microorganisms
JID - 101625893
PMC - PMC8949330
OTO - NOTNLM
OT  - erythema multiforme
OT  - porcine circoviruses
OT  - porcine cytomegalovirus
OT  - porcine endogenous retroviruses
OT  - porcine lymphotropic herpesviruses
OT  - porcine viruses
COIS- The authors declare no conflict of interest. The funders had no role in the 
      design of the study; in the collection, analyses, or interpretation of data; in 
      the writing of the manuscript, or in the decision to publish the results.
EDAT- 2022/03/27 06:00
MHDA- 2022/03/27 06:01
PMCR- 2022/03/18
CRDT- 2022/03/26 01:05
PHST- 2022/02/11 00:00 [received]
PHST- 2022/03/11 00:00 [revised]
PHST- 2022/03/15 00:00 [accepted]
PHST- 2022/03/26 01:05 [entrez]
PHST- 2022/03/27 06:00 [pubmed]
PHST- 2022/03/27 06:01 [medline]
PHST- 2022/03/18 00:00 [pmc-release]
AID - microorganisms10030652 [pii]
AID - microorganisms-10-00652 [pii]
AID - 10.3390/microorganisms10030652 [doi]
PST - epublish
SO  - Microorganisms. 2022 Mar 18;10(3):652. doi: 10.3390/microorganisms10030652.