PMID- 35337613
OWN - NLM
STAT- MEDLINE
DCOM- 20220331
LR  - 20220715
IS  - 1873-4111 (Electronic)
IS  - 0378-5122 (Linking)
VI  - 159
DP  - 2022 May
TI  - Association between reproductive lifespan and risk of incident type 2 diabetes 
      and hypertension in postmenopausal women: Findings from a 20-year prospective 
      study.
PG  - 52-61
LID - S0378-5122(22)00013-5 [pii]
LID - 10.1016/j.maturitas.2022.01.001 [doi]
AB  - BACKGROUND: This study examined the association between reproductive lifespan and 
      incident type 2 diabetes mellitus (T2DM) and hypertension in mid-age women. Also, 
      the combined effect of reproductive lifespan and body mass index (BMI) on the 
      risks of T2DM and hypertension were explored. METHODS: Reproductive lifespan was 
      defined as the difference between age at menopause and age at menarche, and 
      categorized as <35, 35-37, 38-40, and >/=41 years based on the quartile 
      distribution. A multivariable Cox proportional hazard regression was used, 
      adjusting for socio-demographic, lifestyle, and reproductive factors. RESULTS: Of 
      6357 postmenopausal women included (mean [SD] age at last follow-up, 66.3[3.3] 
      years), a total of 655 developed incident T2DM (10.3%) and 1741 developed 
      hypertension (30.0%) during 20 years of follow-up. The total sample had a mean 
      (SD) reproductive lifespan of 37.9 (4.5). Compared with the women who had a 
      reproductive lifespan of 38-40 years, those with a short reproductive lifespan 
      (<35 years) had a 30% increased risk of T2DM and twice the risk of hypertension. 
      Under the combined model, women who had a short reproductive lifespan (<35 years) 
      and who had a BMI >/=30 kg/m(2) at baseline showed a higher risk of T2DM (HR: 6.30, 
      95% CI: 4.41-8.99) and hypertension (HR: 6.06, 4.86-7.55) compared with women who 
      had a reproductive lifespan of 38-40 years and a BMI < 25 kg/m(2). CONCLUSIONS: A 
      higher risk of both incident T2DM and hypertension at midlife was found among 
      women experiencing a shorter reproductive lifespan, with pronounced risk for 
      women experiencing both a short reproductive lifespan (<35 years) and a higher 
      baseline BMI (>/=30 kg/m(2)). Women with a short reproductive lifespan may benefit 
      from maintaining healthy body weight in midlife.
CI  - Copyright (c) 2022. Published by Elsevier B.V.
FAU - Mishra, Shiva R
AU  - Mishra SR
AD  - Centre for Longitudinal and Lifecourse Research, School of Public Health, The 
      University of Queensland, 266 Herston Rd, Brisbane, QLD 4006, Australia. 
      Electronic address: shivaraj.mishra@uq.edu.au.
FAU - Waller, Michael
AU  - Waller M
AD  - Centre for Longitudinal and Lifecourse Research, School of Public Health, The 
      University of Queensland, 266 Herston Rd, Brisbane, QLD 4006, Australia.
FAU - Chung, Hsin-Fang
AU  - Chung HF
AD  - Centre for Longitudinal and Lifecourse Research, School of Public Health, The 
      University of Queensland, 266 Herston Rd, Brisbane, QLD 4006, Australia.
FAU - Mishra, Gita D
AU  - Mishra GD
AD  - Centre for Longitudinal and Lifecourse Research, School of Public Health, The 
      University of Queensland, 266 Herston Rd, Brisbane, QLD 4006, Australia.
LA  - eng
PT  - Journal Article
DEP - 20220111
PL  - Ireland
TA  - Maturitas
JT  - Maturitas
JID - 7807333
SB  - IM
MH  - *Diabetes Mellitus, Type 2/epidemiology/etiology
MH  - Female
MH  - Humans
MH  - *Hypertension/complications/etiology
MH  - Longevity
MH  - Postmenopause
MH  - Prospective Studies
MH  - Risk Factors
OTO - NOTNLM
OT  - Hypertension
OT  - Menarche
OT  - Menopause
OT  - Reproductive lifespan
OT  - Type 2 diabetes
COIS- The authors declare that they have no competing interests.
EDAT- 2022/03/27 06:00
MHDA- 2022/04/01 06:00
CRDT- 2022/03/26 05:26
PHST- 2021/10/10 00:00 [received]
PHST- 2021/12/24 00:00 [revised]
PHST- 2022/01/07 00:00 [accepted]
PHST- 2022/03/26 05:26 [entrez]
PHST- 2022/03/27 06:00 [pubmed]
PHST- 2022/04/01 06:00 [medline]
AID - S0378-5122(22)00013-5 [pii]
AID - 10.1016/j.maturitas.2022.01.001 [doi]
PST - ppublish
SO  - Maturitas. 2022 May;159:52-61. doi: 10.1016/j.maturitas.2022.01.001. Epub 2022 
      Jan 11.