PMID- 35337935
OWN - NLM
STAT- MEDLINE
DCOM- 20220419
LR  - 20220505
IS  - 1874-1754 (Electronic)
IS  - 0167-5273 (Linking)
VI  - 356
DP  - 2022 Jun 1
TI  - Long-term preservation of functional capacity and quality of life in advanced 
      heart failure patients with bridge to transplant therapy: A report from Japanese 
      nationwide multicenter registry.
PG  - 66-72
LID - S0167-5273(22)00403-X [pii]
LID - 10.1016/j.ijcard.2022.03.044 [doi]
AB  - BACKGROUND: Under the revised heart allocation system in the United States, 
      bridge to transplant (BTT) patients with left ventricular assist device (LVAD) 
      have a longer waitlist period, as they are now lowly prioritized. However, little 
      is known regarding the long-term trajectory of functional capacity (FC) and 
      health-related quality of life (HR-QOL) among BTT-LVAD patients. METHODS: We 
      retrospectively analyzed 442 consecutive patients with BTT-LVAD between April 
      2013 and May 2019 from a Japanese nationwide registry. FC (New York Heart 
      Association [NYHA] functional class, peak oxygen uptake [VO(2)], and 6-min walk 
      test [6MWT]) and HR-QOL (European Quality of Life [EQ-5D index] and Visual 
      Analogue Scale [EQ-VAS]) were assessed at baseline and for up to 60 months after 
      LVAD implantation. RESULTS: During the follow-up period of 30 months (IQR 
      18-42 months), 100 (22.6%) patients underwent transplantation, 37 (8.3%) died, 
      and 14 (3.1%) underwent explantation for recovery. Mean peak VO(2), 6MWT 
      distance, EQ-5D index, and EQ-VAS significantly improved 3 months after LVAD 
      implantation (p = 0.0012, p = 0.0037, p < 0.001, p < 0.001, respectively). 
      Furthermore, these improvements were sustained for up to 60 months following LVAD 
      implantation. Major adverse events including device failure, infection, stroke, 
      and bleeding, which occurred within the first 3 months after LVAD implantation 
      may have not affected FC or HR-QOL for up to 60 months (p = 0.15, p = 0.22, 
      respectively). CONCLUSIONS: BTT patients showed long-term preservation of FC and 
      HR-QOL, suggesting that BTT remains an option despite the long waiting time to 
      HTx.
CI  - Copyright (c) 2022 Elsevier B.V. All rights reserved.
FAU - Sato, Takuma
AU  - Sato T
AD  - Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of 
      Medicine, Hokkaido University, Sapporo, Japan.
FAU - Kobayashi, Yuta
AU  - Kobayashi Y
AD  - Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of 
      Medicine, Hokkaido University, Sapporo, Japan.
FAU - Nagai, Toshiyuki
AU  - Nagai T
AD  - Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of 
      Medicine, Hokkaido University, Sapporo, Japan. Electronic address: 
      nagai@med.hokudai.ac.jp.
FAU - Nakatani, Takeshi
AU  - Nakatani T
AD  - Maki Hospital, Osaka, Japan.
FAU - Kobashigawa, Jon
AU  - Kobashigawa J
AD  - Cedars-Sinai Smidt Heart Institute, Cedars Sinai Medical Center, Los Angeles, CA, 
      USA.
FAU - Saiki, Yoshikatsu
AU  - Saiki Y
AD  - Division of Cardiovascular Surgery, Tohoku University Graduate School of 
      Medicine, Sendai, Japan.
FAU - Ono, Minoru
AU  - Ono M
AD  - Department of Cardiovascular Surgery, The University of Tokyo, Tokyo, Japan.
FAU - Wakasa, Satoru
AU  - Wakasa S
AD  - Department of Cardiovascular and Thoracic Surgery, Faculty of Medicine and 
      Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
FAU - Anzai, Toshihisa
AU  - Anzai T
AD  - Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of 
      Medicine, Hokkaido University, Sapporo, Japan.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20220323
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
SB  - IM
MH  - *Heart Failure/diagnosis/surgery
MH  - *Heart Transplantation
MH  - *Heart-Assist Devices/adverse effects
MH  - Humans
MH  - Japan/epidemiology
MH  - Quality of Life
MH  - Registries
MH  - Retrospective Studies
MH  - Treatment Outcome
MH  - United States
OTO - NOTNLM
OT  - Bridge to transplant
OT  - Functional capacity
OT  - Left ventricular assist device
OT  - Patient-reported outcome
OT  - Quality of life
EDAT- 2022/03/27 06:00
MHDA- 2022/04/20 06:00
CRDT- 2022/03/26 05:28
PHST- 2021/11/22 00:00 [received]
PHST- 2022/02/24 00:00 [revised]
PHST- 2022/03/18 00:00 [accepted]
PHST- 2022/03/27 06:00 [pubmed]
PHST- 2022/04/20 06:00 [medline]
PHST- 2022/03/26 05:28 [entrez]
AID - S0167-5273(22)00403-X [pii]
AID - 10.1016/j.ijcard.2022.03.044 [doi]
PST - ppublish
SO  - Int J Cardiol. 2022 Jun 1;356:66-72. doi: 10.1016/j.ijcard.2022.03.044. Epub 2022 
      Mar 23.