PMID- 35338387
OWN - NLM
STAT- MEDLINE
DCOM- 20220518
LR  - 20220910
IS  - 1432-2072 (Electronic)
IS  - 0033-3158 (Linking)
VI  - 239
IP  - 5
DP  - 2022 May
TI  - The effects of prenatal nicotine and THC E-cigarette exposure on motor 
      development in rats.
PG  - 1579-1591
LID - 10.1007/s00213-022-06095-8 [doi]
AB  - RATIONALE: In the USA, nicotine and cannabis are the most common licit and 
      illicit drugs used among pregnant women. Importantly, nicotine and cannabis are 
      now being combined for consumption via e-cigarettes, an increasingly popular 
      delivery device. Both nicotine and tetrahydrocannabinol (THC), the primary 
      psychoactive component of cannabis, cross the placenta barrier. However, the 
      consequences of prenatal cannabis use are not well understood, and less is known 
      about potential combination effects when consumed with nicotine, especially via 
      e-cigarettes. OBJECTIVE: The present study used a rodent model to examine how 
      prenatal e-cigarette exposure to nicotine, THC, and the combination impacts motor 
      development among offspring. METHODS: Pregnant Sprague-Dawley rats were exposed 
      to nicotine (36 mg/mL), THC (100 mg/mL), the combination, or vehicle via 
      e-cigarette inhalation from gestational days (GD) 5-20. One sex pair per litter 
      was tested on an early sensorimotor development task (postnatal days [PD] 12-20) 
      and a parallel bar motor coordination task (PD 30-32). RESULTS: Combined prenatal 
      exposure to nicotine and THC delayed sensorimotor development, even though 
      neither drug produced impairments on their own. In contrast, prenatal exposure to 
      either nicotine or THC impaired motor coordination, whereas combined exposure 
      exacerbated these effects, particularly among females. CONCLUSIONS: These data 
      illustrate that prenatal exposure to either nicotine or THC may alter motor 
      development, and that the combination may produce more severe effects. These 
      findings have important implications for pregnant women as we better understand 
      the teratogenic effects of these drugs consumed via e-cigarettes.
CI  - (c) 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Hussain, S
AU  - Hussain S
AD  - Center for Behavioral Teratology, Department of Psychology, San Diego State 
      University, CA, San Diego, USA.
FAU - Breit, K R
AU  - Breit KR
AD  - Center for Behavioral Teratology, Department of Psychology, San Diego State 
      University, CA, San Diego, USA.
AD  - Department of Psychology, West Chester University of Pennsylvania, West Chester, 
      PA, USA.
FAU - Thomas, J D
AU  - Thomas JD
AD  - Center for Behavioral Teratology, Department of Psychology, San Diego State 
      University, CA, San Diego, USA. Thomas3@sdsu.edu.
LA  - eng
GR  - R21 AA025425/AA/NIAAA NIH HHS/United States
GR  - 28IP-0026/Tobacco-Related Disease Research Program/
GR  - T32AA007456-38/AA/NIAAA NIH HHS/United States
PT  - Journal Article
DEP - 20220326
PL  - Germany
TA  - Psychopharmacology (Berl)
JT  - Psychopharmacology
JID - 7608025
RN  - 0 (Cannabinoid Receptor Agonists)
RN  - 0 (Hallucinogens)
RN  - 6M3C89ZY6R (Nicotine)
RN  - 7J8897W37S (Dronabinol)
SB  - IM
MH  - Animals
MH  - Cannabinoid Receptor Agonists/pharmacology
MH  - Dronabinol/toxicity
MH  - *Electronic Nicotine Delivery Systems
MH  - Female
MH  - *Hallucinogens
MH  - Humans
MH  - Nicotine/toxicity
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Rats
MH  - Rats, Sprague-Dawley
OTO - NOTNLM
OT  - Behavior
OT  - Cannabis
OT  - E-cigarette
OT  - Motor
OT  - Nicotine
OT  - Prenatal
OT  - THC
EDAT- 2022/03/27 06:00
MHDA- 2022/05/19 06:00
CRDT- 2022/03/26 05:31
PHST- 2021/10/22 00:00 [received]
PHST- 2022/02/13 00:00 [accepted]
PHST- 2022/03/27 06:00 [pubmed]
PHST- 2022/05/19 06:00 [medline]
PHST- 2022/03/26 05:31 [entrez]
AID - 10.1007/s00213-022-06095-8 [pii]
AID - 10.1007/s00213-022-06095-8 [doi]
PST - ppublish
SO  - Psychopharmacology (Berl). 2022 May;239(5):1579-1591. doi: 
      10.1007/s00213-022-06095-8. Epub 2022 Mar 26.