PMID- 35339171
OWN - NLM
STAT- MEDLINE
DCOM- 20220331
LR  - 20220401
IS  - 1042-7260 (Print)
IS  - 1042-7260 (Linking)
VI  - 53
IP  - 1
DP  - 2022 Mar
TI  - NOVEL DIAGNOSTIC AND THERAPEUTIC APPROACHES TO ELEPHANT ENDOTHELIOTROPIC 
      HERPESVIRUS 1A HEMORRHAGIC DISEASE IN A CAPTIVE JUVENILE ASIAN ELEPHANT (ELEPHAS 
      MAXIMUS).
PG  - 232-240
LID - 10.1638/2021-0096 [doi]
AB  - Novel diagnostic and therapeutic methods were utilized in the successful 
      management of severe elephant endotheliotropic herpesvirus hemorrhagic disease 
      (EEHV-HD) in a 1.9-yr-old captive Asian elephant (Elephas maximus). High levels 
      of EEHV1A viremia were detected for 12 d. In addition to established EEHV 
      treatments, therapies included famciclovir-fortified elephant whole blood and 
      plasma, mesenchymal stem cells harvested from elephant umbilical tissue, and 
      aminocaproic acid. Testing conducted to examine the effects of EEHV infection on 
      hemostasis suggested marked intravascular coagulation with decreased plasminogen 
      activity and increased D-dimer concentrations. Thromboelastography was used to 
      assess the efficacy of aminocaproic acid and demonstrated hypofibrinolysis on 
      samples taken after drug administration, as compared with samples from healthy 
      adult Asian elephants. A serological assay for a novel EEHV1A-specific antibody 
      marker (E52) was developed due to lack of seroconversion to a previously 
      established EEHV1A-specific antibody marker (ORFQ) and showed a sustained 
      increase after EEHV-HD illness.
FAU - Iyer, Maya L
AU  - Iyer ML
AD  - Karen C. Drayer Wildlife Health Center, School of Veterinary Medicine, University 
      of California, Davis, CA 95616, USA, miyer@ucdavis.edu.
FAU - Molter, Christine M
AU  - Molter CM
AD  - Veterinary Services, Houston Zoo, Inc, Houston, TX 77030, USA, 
      cmolter@houstonzoo.org.
FAU - Flanagan, Joseph P
AU  - Flanagan JP
AD  - Veterinary Services, Houston Zoo, Inc, Houston, TX 77030, USA.
FAU - Bauer, Kendra L
AU  - Bauer KL
AD  - Veterinary Services, Houston Zoo, Inc, Houston, TX 77030, USA.
FAU - Bernardy, Rob
AU  - Bernardy R
AD  - Veterinary Services, Houston Zoo, Inc, Houston, TX 77030, USA.
FAU - Hoffman, Daryl
AU  - Hoffman D
AD  - Veterinary Services, Houston Zoo, Inc, Houston, TX 77030, USA.
FAU - Parkinson, Lily
AU  - Parkinson L
AD  - Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, 
      University of Georgia, Athens, GA 30602, USA.
FAU - Brainard, Benjamin M
AU  - Brainard BM
AD  - Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, 
      University of Georgia, Athens, GA 30602, USA.
FAU - Evans, Tierra Smiley
AU  - Evans TS
AD  - Karen C. Drayer Wildlife Health Center, School of Veterinary Medicine, University 
      of California, Davis, CA 95616, USA.
FAU - Pursell, Taylor
AU  - Pursell T
AD  - Department of Molecular Virology and Microbiology, Baylor College of Medicine, 
      One Baylor Plaza, Houston, TX 77030, USA.
FAU - Ling, Paul D
AU  - Ling PD
AD  - Department of Molecular Virology and Microbiology, Baylor College of Medicine, 
      One Baylor Plaza, Houston, TX 77030, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Zoo Wildl Med
JT  - Journal of zoo and wildlife medicine : official publication of the American 
      Association of Zoo Veterinarians
JID - 8915208
RN  - QIC03ANI02 (Famciclovir)
SB  - IM
MH  - Animals
MH  - *Elephants
MH  - Famciclovir
MH  - *Herpesviridae
MH  - *Herpesviridae Infections/diagnosis/drug therapy/veterinary
MH  - Viremia/veterinary
EDAT- 2022/03/28 06:00
MHDA- 2022/04/01 06:00
CRDT- 2022/03/27 17:59
PHST- 2021/12/19 00:00 [accepted]
PHST- 2022/03/27 17:59 [entrez]
PHST- 2022/03/28 06:00 [pubmed]
PHST- 2022/04/01 06:00 [medline]
AID - 10.1638/2021-0096 [doi]
PST - ppublish
SO  - J Zoo Wildl Med. 2022 Mar;53(1):232-240. doi: 10.1638/2021-0096.