PMID- 3534009
OWN - NLM
STAT- MEDLINE
DCOM- 19861201
LR  - 20190709
IS  - 0190-9622 (Print)
IS  - 0190-9622 (Linking)
VI  - 15
IP  - 4 Pt 1
DP  - 1986 Oct
TI  - T-cell growth factor receptor (Tac-antigen) expression in cutaneous lymphoid 
      infiltrates.
PG  - 628-37
AB  - A total of ninety-four biopsies from normal skin, benign dermatoses, and lesions 
      of human T cell lymphotropic virus type I (HTLV-I)-positive and -negative 
      cutaneous T cell disorders have been examined immunohistologically for reactivity 
      with anti-Tac (monoclonal anti-T cell growth factor receptor). Tac-positive T 
      cells were plentiful in approximately half the specimens, and they were equally 
      frequent in benign and malignant disorders and in HTLV-I-positive and -negative 
      cutaneous T cell disorders. Furthermore, in diseased skin, reactivity with 
      anti-Tac was not confined to T lymphocytes, since it was also a property of 
      dermal macrophages and Langerhans cells, as shown by examination of serial and/or 
      double-stained sections. Comparison with other markers linked to T cell 
      activation and proliferation (i.e., HLA-DR, OKT10 antigen, transferrin receptor, 
      and the Ki-67 nuclear antigen) showed that Tac-antigen expression did not 
      correlate clearly with any of these markers. These data indicate that anti-Tac 
      forms a useful supplement to other monoclonal antibodies for the identification 
      of activated cell subsets in cutaneous lymphoid infiltrates, but they also show 
      that the use of this reagent on cutaneous biopsy specimens is of only limited 
      diagnostic value.
FAU - Ralfkiaer, E
AU  - Ralfkiaer E
FAU - Wantzin, G L
AU  - Wantzin GL
FAU - Stein, H
AU  - Stein H
FAU - Thomsen, K
AU  - Thomsen K
FAU - Mason, D Y
AU  - Mason DY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Am Acad Dermatol
JT  - Journal of the American Academy of Dermatology
JID - 7907132
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Interleukin-2)
RN  - 0 (Receptors, Immunologic)
SB  - IM
MH  - Antibodies, Monoclonal/immunology
MH  - Fluorescent Antibody Technique
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Interleukin-2/*immunology
MH  - Langerhans Cells/immunology
MH  - Lymphatic Diseases/*immunology
MH  - Macrophages/immunology
MH  - Receptors, Immunologic/*immunology
MH  - Skin/immunology
MH  - Skin Diseases/*immunology
MH  - T-Lymphocytes/immunology
EDAT- 1986/10/01 00:00
MHDA- 1986/10/01 00:01
CRDT- 1986/10/01 00:00
PHST- 1986/10/01 00:00 [pubmed]
PHST- 1986/10/01 00:01 [medline]
PHST- 1986/10/01 00:00 [entrez]
AID - S0190-9622(86)70216-8 [pii]
AID - 10.1016/s0190-9622(86)70216-8 [doi]
PST - ppublish
SO  - J Am Acad Dermatol. 1986 Oct;15(4 Pt 1):628-37. doi: 
      10.1016/s0190-9622(86)70216-8.