PMID- 35340111
OWN - NLM
STAT- MEDLINE
DCOM- 20220622
LR  - 20220623
IS  - 1473-2165 (Electronic)
IS  - 1473-2130 (Linking)
VI  - 21
IP  - 6
DP  - 2022 Jun
TI  - TNF-alpha gene -238G>A polymorphism is associated with psoriasis patients.
PG  - 2662-2667
LID - 10.1111/jocd.14940 [doi]
AB  - BACKGROUND: Tumor necrosis factor-alpha (TNF-alpha) is a protein that plays a key 
      role in the pathophysiology of chronic inflammatory disorders like psoriasis. 
      AIMS: The goal of this study was to see whether the TNF-alpha gene -238G>A 
      polymorphism was linked to psoriasis susceptibility. METHODS: This study 
      comprised 90 psoriasis patients and ninety healthy controls. For the TNF-alpha gene 
      -238G>A polymorphism, genomic DNA was extracted and genotyped using polymerase 
      chain reaction (PCR) and restriction fragment length polymorphism (RFLP) studies. 
      RESULTS: Psoriasis patients had higher frequencies of the A allele and the AA 
      genotype than the control group, and psoriasis was linked to the AA genotype 
      (OR = 4.25, 95% CI = 1.37-13.1, p = 0.008) and the A allele (OR = 1.55, 95% 
      CI = 1.01-2.34, p = 0.04). Patients with a family history of psoriasis showed an 
      increase in the frequency of the AA genotype compared with GG and GA genotypes 
      (46.7%, 36.7%, and 16.7%, p = 0.003, respectively). Furthermore, psoriasis 
      patients with the AA genotype were discovered more commonly among those under 
      30 years of age and male patients than those with the GG and GA genotypes, but 
      the differences were not statistically significant. CONCLUSION: The TNF-alpha gene 
      -238G>A polymorphism has been related to an increased incidence of psoriasis.
CI  - (c) 2022 Wiley Periodicals LLC.
FAU - Akcilar, Raziye
AU  - Akcilar R
AUID- ORCID: 0000-0003-4720-1945
AD  - Department of Physiology, Faculty of Medicine, Kutahya Health Sciences 
      University, Kutahya, Turkey.
FAU - Dizen Namdar, Nazli
AU  - Dizen Namdar N
AD  - Department of Dermatology, Faculty of Medicine, Kutahya Health Sciences 
      University, Kutahya, Turkey.
FAU - Yukcu, Fulya
AU  - Yukcu F
AD  - Department of Biophysics, Faculty of Medicine, Kutahya Health Sciences 
      University, Kutahya, Turkey.
FAU - Arslan Utku, Selve
AU  - Arslan Utku S
AD  - Department of Dermatology, Faculty of Medicine, Kutahya Health Sciences 
      University, Kutahya, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20220409
PL  - England
TA  - J Cosmet Dermatol
JT  - Journal of cosmetic dermatology
JID - 101130964
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Case-Control Studies
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Male
MH  - Polymorphism, Genetic
MH  - Promoter Regions, Genetic
MH  - *Psoriasis/genetics
MH  - *Tumor Necrosis Factor-alpha/genetics
OTO - NOTNLM
OT  - TNF-alpha gene -238G>A polymorphism
OT  - psoriasis
OT  - rs361525
EDAT- 2022/03/28 06:00
MHDA- 2022/06/23 06:00
CRDT- 2022/03/27 20:28
PHST- 2022/02/28 00:00 [revised]
PHST- 2021/11/04 00:00 [received]
PHST- 2022/03/23 00:00 [accepted]
PHST- 2022/03/28 06:00 [pubmed]
PHST- 2022/06/23 06:00 [medline]
PHST- 2022/03/27 20:28 [entrez]
AID - 10.1111/jocd.14940 [doi]
PST - ppublish
SO  - J Cosmet Dermatol. 2022 Jun;21(6):2662-2667. doi: 10.1111/jocd.14940. Epub 2022 
      Apr 9.