PMID- 35342125
OWN - NLM
STAT- MEDLINE
DCOM- 20220527
LR  - 20221207
IS  - 1347-4820 (Electronic)
IS  - 1346-9843 (Linking)
VI  - 86
IP  - 6
DP  - 2022 May 25
TI  - Impact of Serum Zinc Level and Oral Zinc Supplementation on Clinical Outcomes in 
      Patients Undergoing Infrainguinal Bypass for Chronic Limb-Threatening Ischemia.
PG  - 995-1006
LID - 10.1253/circj.CJ-21-0832 [doi]
AB  - BACKGROUND: Zinc (Zn) has been reported to play an important role in wound 
      healing (WH). Nevertheless, the effect of Zn in chronic limb-threatening ischemia 
      (CLTI) patients is unclear. This study investigated the effect of Zn on the 
      clinical outcomes of CLTI patients undergoing bypass surgery.Methods and Results: 
      This study reviewed 111 consecutive patients who underwent an infrainguinal 
      bypass from 2012 to 2020. Patients with Zn deficiency (serum Zn level <60 mug/dL) 
      received oral Zn supplementation and maintained a normal level until WH. This 
      study aimed to explore: (1) the effect of Zn deficiency; and (2) Zn 
      supplementation in Zn-deficient patients on the clinical outcomes of this cohort. 
      Patients with Zn deficiency, Zn supplementation, and no Zn supplementation 
      despite Zn deficiency accounted for 48, 21, and 42 patients, respectively. (1) Zn 
      deficiency was associated with WH (HR, 0.47; 95% CI, 0.29-0.78: P=0.003), major 
      adverse limb events (MALE) (HR, 2.53; 95% CI, 1.26-5.09: P=0.009), and major 
      amputation or death (HR, 3.17; 95% CI, 1.51-6.63: P=0.002). (2) Zn 
      supplementation was positively related to WH (HR, 2.30; 95% CI, 1.21-4.34: 
      P=0.011). This result was confirmed using propensity score matching (HR, 2.24; 
      95% CI, 1.02-4.87: P=0.043). CONCLUSIONS: The current study revealed that Zn 
      level was associated with clinical outcomes in CLTI patients after bypass 
      surgery. Oral Zn supplementation could improve WH in these patients.
FAU - Kodama, Akio
AU  - Kodama A
AD  - Division of Vascular and Endovascular Surgery, Department of Surgery, Nagoya 
      University School of Medicine.
FAU - Komori, Kimihiro
AU  - Komori K
AD  - Division of Vascular and Endovascular Surgery, Department of Surgery, Nagoya 
      University School of Medicine.
FAU - Koyama, Akio
AU  - Koyama A
AD  - Department of Vascular Surgery, Ichinomiya Municipal Hospital.
FAU - Sato, Tomohiro
AU  - Sato T
AD  - Division of Vascular and Endovascular Surgery, Department of Surgery, Nagoya 
      University School of Medicine.
FAU - Ikeda, Shuta
AU  - Ikeda S
AD  - Division of Vascular and Endovascular Surgery, Department of Surgery, Nagoya 
      University School of Medicine.
FAU - Tsuruoka, Takuya
AU  - Tsuruoka T
AD  - Division of Vascular and Endovascular Surgery, Department of Surgery, Nagoya 
      University School of Medicine.
FAU - Kawai, Yohei
AU  - Kawai Y
AD  - Division of Vascular and Endovascular Surgery, Department of Surgery, Nagoya 
      University School of Medicine.
FAU - Niimi, Kiyoaki
AU  - Niimi K
AD  - Division of Vascular and Endovascular Surgery, Department of Surgery, Nagoya 
      University School of Medicine.
FAU - Sugimoto, Masayuki
AU  - Sugimoto M
AD  - Division of Vascular and Endovascular Surgery, Department of Surgery, Nagoya 
      University School of Medicine.
FAU - Banno, Hiroshi
AU  - Banno H
AD  - Division of Vascular and Endovascular Surgery, Department of Surgery, Nagoya 
      University School of Medicine.
FAU - Nishida, Kazuki
AU  - Nishida K
AD  - Biostatistics and Bioinformatics Section, Center for Advanced Medicine and 
      Clinical Research, Nagoya University Hospital.
LA  - eng
PT  - Journal Article
DEP - 20220326
PL  - Japan
TA  - Circ J
JT  - Circulation journal : official journal of the Japanese Circulation Society
JID - 101137683
RN  - J41CSQ7QDS (Zinc)
SB  - IM
MH  - Amputation, Surgical
MH  - Chronic Disease
MH  - Chronic Limb-Threatening Ischemia
MH  - Dietary Supplements
MH  - Humans
MH  - Ischemia/complications/drug therapy/surgery
MH  - *Limb Salvage
MH  - *Peripheral Arterial Disease
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Risk Factors
MH  - Time Factors
MH  - Treatment Outcome
MH  - Zinc
OTO - NOTNLM
OT  - Bypass surgery
OT  - Chronic limb-threatening ischemia
OT  - Zinc
EDAT- 2022/03/29 06:00
MHDA- 2022/05/28 06:00
CRDT- 2022/03/28 05:29
PHST- 2022/03/29 06:00 [pubmed]
PHST- 2022/05/28 06:00 [medline]
PHST- 2022/03/28 05:29 [entrez]
AID - 10.1253/circj.CJ-21-0832 [doi]
PST - ppublish
SO  - Circ J. 2022 May 25;86(6):995-1006. doi: 10.1253/circj.CJ-21-0832. Epub 2022 Mar 
      26.