PMID- 35342448
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220329
IS  - 1735-1995 (Print)
IS  - 1735-7136 (Electronic)
IS  - 1735-1995 (Linking)
VI  - 27
DP  - 2022
TI  - Correlation of serum apelin level with carotid intima-media thickness and insulin 
      resistance in a sample of Egyptian patients with type 2 diabetes mellitus.
PG  - 13
LID - 10.4103/jrms.JRMS_675_20 [doi]
LID - 13
AB  - BACKGROUND: Type 2 diabetes mellitus (T2DM) is a growing health problem in Egypt, 
      with a significant impact on morbidity and mortality. Measurement of the carotid 
      Intima-media thickness (CIMT) allows early detection of atherosclerotic blood 
      vessel diseases. Apelin is an adipose tissue-derived hormone that may be 
      associated with insulin resistance (IR). This study aimed to assess the level of 
      serum apelin in patients with T2DM and its relation to IR and CIMT. MATERIALS AND 
      METHODS: A case-control study was conducted on 60 patients with T2DM and 30 
      healthy controls. T2DM was diagnosed based on American Diabetes Association 
      criteria. The study was carried out at Al-Zahraa University Hospital, Cairo, 
      Egypt, through the period from June to December 2019. The laboratory 
      investigations included serum apelin and blood glucose hemostasis markers. CIMT 
      was assessed using B-mode ultrasonography. RESULTS: Patients' group had a 
      statistically significant higher apelin level than healthy controls (407.96 +/- 
      291.07 versus 83.32 +/- 10.55 ng/dL, P < 0.001). The correlation analysis showed 
      that the serum apelin level correlated positively with glycemic indices, body 
      weight, and waist circumference (P < 0.05). At cutoff value of >96 ng/dL, the 
      serum apelin exhibited a sensitivity of 98.3% and specificity of 96.7%, positive 
      predictive value of 98.1%, and negative predictive value of 96.5%, with a 
      diagnostic accuracy of 95.1%. Serum apelin correlated positively with CIMT (r = 
      0.296, P = 0.022). Logistic regression analysis showed that systolic and 
      diastolic blood pressures, Homeostasis Model Assessment of IR, and CIMT were 
      independent predictors of serum apelin. CONCLUSION: Serum apelin may be 
      correlated with the degree of carotid atherosclerosis and hence can be used as a 
      prognostic biomarker.
CI  - Copyright: (c) 2022 Journal of Research in Medical Sciences.
FAU - El Wakeel, Mervat El Shahat
AU  - El Wakeel MES
AD  - Department of Endocrinology and Metabolism, Faculty of Medicine for Girls, 
      Al-Azhar University, Cairo, Egypt.
FAU - Ahmad, Inass Hassan
AU  - Ahmad IH
AD  - Department of Endocrinology and Metabolism, Faculty of Medicine for Girls, 
      Al-Azhar University, Cairo, Egypt.
FAU - Mohammed, Marwa Abdelmonim
AU  - Mohammed MA
AD  - Department of Internal Medicine, Faculty of Medicine for Girls, Al-Azhar 
      University, Cairo, Egypt.
FAU - Ali, Sally Mohamed Osama
AU  - Ali SMO
AD  - Department of Radiology, Faculty of Medicine for Girls, Al-Azhar University, 
      Cairo, Egypt.
FAU - El Wahab, Marwa Khairy Abd
AU  - El Wahab MKA
AD  - Department of Clinical Pathology, Faculty of Medicine for Girls in Cairo, 
      Al-Azhar University, Cairo, Egypt.
FAU - Shipl, Walaa Mohamed
AU  - Shipl WM
AD  - Department of Biochemistry, Faculty of Medicine for Girls, Al-Azhar University, 
      Cairo, Egypt.
LA  - eng
PT  - Journal Article
DEP - 20220218
PL  - India
TA  - J Res Med Sci
JT  - Journal of research in medical sciences : the official journal of Isfahan 
      University of Medical Sciences
JID - 101235599
PMC - PMC8943574
OTO - NOTNLM
OT  - Apelin
OT  - carotid intima-media thickness
OT  - insulin resistance
OT  - type 2 diabetes
COIS- There are no conflicts of interest.
EDAT- 2022/03/29 06:00
MHDA- 2022/03/29 06:01
PMCR- 2022/02/18
CRDT- 2022/03/28 05:30
PHST- 2020/07/13 00:00 [received]
PHST- 2021/05/22 00:00 [revised]
PHST- 2021/09/01 00:00 [accepted]
PHST- 2022/03/28 05:30 [entrez]
PHST- 2022/03/29 06:00 [pubmed]
PHST- 2022/03/29 06:01 [medline]
PHST- 2022/02/18 00:00 [pmc-release]
AID - JRMS-27-13 [pii]
AID - 10.4103/jrms.JRMS_675_20 [doi]
PST - epublish
SO  - J Res Med Sci. 2022 Feb 18;27:13. doi: 10.4103/jrms.JRMS_675_20. eCollection 
      2022.