PMID- 35344678
OWN - NLM
STAT- MEDLINE
DCOM- 20220602
LR  - 20220602
IS  - 1521-0553 (Electronic)
IS  - 0894-1939 (Linking)
VI  - 35
IP  - 6
DP  - 2022 Jun
TI  - Lymphadenectomy in Primary Fallopian Tube Cancer is Associated with Improved 
      Survival.
PG  - 1417-1423
LID - 10.1080/08941939.2022.2048142 [doi]
AB  - BACKGROUND AND OBJECTIVES: Primary fallopian tube cancer (PFTC) shares the same 
      diagnostic and management guidelines with epithelial ovarian cancer (EOC). The 
      LION trail raised concerns regarding the role of systematic pelvic and 
      para-aortic lymphadenectomy during debulking surgery. We aimed to evaluate the 
      significance of lymphadenectomy in PFTC survival. METHODS: This retrospective 
      study analyzed the clinical features and survival of patients with PFTC who 
      underwent primary surgery in our center between January 2013 and October 2020. 
      RESULTS: Sixty-one patients diagnosed with PFTC were included in the study. 
      Twenty-five (41.0%, 25/61) were diagnosed with FIGO (International Federation of 
      Gynecology and Obstetrics) stages I/II and 36 (59.0%, 36/61) were diagnosed with 
      stage III/IV. Twenty-nine (47.5%, 29/61) underwent pelvic lymphadenectomy with or 
      without para-aortic lymphadenectomy, among which 12 (41.4%, 12/29) had lymph node 
      metastasis confirmed by postoperative pathology. The mean progression-free 
      survival was 60.4 months in the lymphadenectomy group and 37.8 months in the 
      no-lymphadenectomy group (p = 0.042, HR 0.374, 95% CI 0.145-0.966). CONCLUSIONS: 
      PFTC is often diagnosed earlier and has a better prognosis than EOC. Most 
      patients with PFTC would benefit from lymphadenectomy. However, the extent to 
      which this association translates to a more diverse population needs to be 
      further identified.
FAU - Xiao, Yao
AU  - Xiao Y
AD  - Department of Gynecology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, China.
FAU - Liu, Yue-Xi
AU  - Liu YX
AD  - Department of Gynecology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, China.
FAU - Li, Ruo-Nan
AU  - Li RN
AD  - Department of Gynecology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, China.
FAU - Wei, Xing
AU  - Wei X
AD  - Department of Gynecology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, China.
FAU - Wang, Qing-Miao
AU  - Wang QM
AD  - Department of Gynecology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, China.
FAU - Gu, Qiu-Ying
AU  - Gu QY
AD  - Department of Gynecology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, China.
FAU - Linghu, Hua
AU  - Linghu H
AD  - Department of Gynecology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, China.
LA  - eng
PT  - Journal Article
DEP - 20220328
PL  - United States
TA  - J Invest Surg
JT  - Journal of investigative surgery : the official journal of the Academy of 
      Surgical Research
JID - 8809255
SB  - IM
CIN - J Invest Surg. 2022 Jun;35(6):1424-1425. PMID: 35345963
MH  - *Fallopian Tube Neoplasms/diagnosis/pathology/surgery
MH  - Female
MH  - Humans
MH  - Lymph Node Excision
MH  - Lymphatic Metastasis
MH  - *Ovarian Neoplasms/diagnosis/surgery
MH  - Retrospective Studies
OTO - NOTNLM
OT  - Gynecology
OT  - fallopian tube cancer
OT  - lymphadenectomy
OT  - prognosis
OT  - surgery
EDAT- 2022/03/29 06:00
MHDA- 2022/06/03 06:00
CRDT- 2022/03/28 20:08
PHST- 2022/03/29 06:00 [pubmed]
PHST- 2022/06/03 06:00 [medline]
PHST- 2022/03/28 20:08 [entrez]
AID - 10.1080/08941939.2022.2048142 [doi]
PST - ppublish
SO  - J Invest Surg. 2022 Jun;35(6):1417-1423. doi: 10.1080/08941939.2022.2048142. Epub 
      2022 Mar 28.