PMID- 35344908 OWN - NLM STAT- MEDLINE DCOM- 20220608 LR - 20220608 IS - 2211-0356 (Electronic) IS - 2211-0348 (Linking) VI - 61 DP - 2022 May TI - Efficacy and safety of rehabilitation exercise in neuromyelitis optica spectrum disorder during the acute phase: A prospective cohort study. PG - 103726 LID - S2211-0348(22)00241-3 [pii] LID - 10.1016/j.msard.2022.103726 [doi] AB - BACKGROUND: Rehabilitation treatment may alleviate the disease severity of patients with NMOSD. The reports of rehabilitation exercise for NMOSD during acute phase are rare. OBJECTIVE: To explore the efficacy and safety of rehabilitation exercise in patients with NMOSD during acute phase. METHODS: This is a prospective cohort study of 36 patients (rehabilitation exercise group, RG) and 37 patients (control group, CG) in whom acute attack of NMOSD involved the spinal cord with EDSS>/=4.5 were included. EDSS, American Spinal Injury Association Impairment Scale (AIS) grade, total motor score (TMS), light touch score (LTS), pin prick score (PPS), Berg balance scale (BBS), and Barthel index (BI) were used as outcome measures. RESULTS: During hospitalization, EDSS scores of both groups decreased significantly (P<0.05). After treatment, the decline in EDSS was more significant in RG than in CG (P<0.05). The change reaching minimal clinically important difference (MCID) was observed in 90% (9/10) of patients in RG and in 27.78% (5/18) of patients in CG in the subgroup with EDSS 4.5-6.0 (MCID, 1.0), which was statistically significant between the groups (P<0.05). In the subgroup with EDSS 6.5-10.0 (MCID, 0.5), the proportion of patients with the change that reached MCID was significantly different between CG and RG (P<0.05). BBS, TMS, and BI score significantly improved after treatment (P<0.001). The improvement ranges of BBS, TMS, and BI scores were more significant in RG than CG (P<0.05). AIS grade improvement in RG was significantly higher than in CG. There were no significant changes in LTS and PPS after treatment in either of the groups. In RG, two mild adverse events were recorded. CONCLUSION: Rehabilitation exercise may improve nervous system function, balance function, and activities of daily living in patients with acute NMOSD, with few adverse reactions. CI - Copyright (c) 2022. Published by Elsevier B.V. FAU - Li, Qinying AU - Li Q AD - Department of Rehabilitation Medicine, Jing'an District Centre Hospital of Shanghai, Fudan University, Shanghai 200040, China. FAU - Wang, Bei AU - Wang B AD - Department of Neurology, Jing'an District Centre Hospital of Shanghai, Fudan University, Shanghai 200040, China. FAU - Cheng, Bingyuan AU - Cheng B AD - Department of Rehabilitation Medicine, Jing'an District Centre Hospital of Shanghai, Fudan University, Shanghai 200040, China. FAU - Liu, Chi AU - Liu C AD - Department of Geriatrics Center & National Clinical Research Center for Aging and Medicine, Jing'an District Centre Hospital of Shanghai, Fudan University, Shanghai 200040, China. FAU - Li, Nan AU - Li N AD - Department of Rehabilitation and Sports Medicine, The Second Affiliated Hospital of Anhui Medical University, Hehui, Anhui Province, 230601, China. FAU - Dai, Guifeng AU - Dai G AD - Department of Geriatrics Center & National Clinical Research Center for Aging and Medicine, Jing'an District Centre Hospital of Shanghai, Fudan University, Shanghai 200040, China. FAU - Xiao, Han AU - Xiao H AD - Department of Rehabilitation and Sports Medicine, The Second Affiliated Hospital of Anhui Medical University, Hehui, Anhui Province, 230601, China. FAU - Zhou, Lei AU - Zhou L AD - Department of Neurology, Huashan Hospital, Fudan University, Shanghai 200040, China; National center for neurological disorders NCND, Shanghai 200040, China. FAU - ZhangBao, Jingzi AU - ZhangBao J AD - Department of Neurology, Huashan Hospital, Fudan University, Shanghai 200040, China; National center for neurological disorders NCND, Shanghai 200040, China. FAU - Wang, Liang AU - Wang L AD - Department of Neurology, Huashan Hospital, Fudan University, Shanghai 200040, China; National center for neurological disorders NCND, Shanghai 200040, China. FAU - Zhao, Chongbo AU - Zhao C AD - Department of Neurology, Huashan Hospital, Fudan University, Shanghai 200040, China; National center for neurological disorders NCND, Shanghai 200040, China. FAU - Lu, Jiahong AU - Lu J AD - Department of Neurology, Huashan Hospital, Fudan University, Shanghai 200040, China; National center for neurological disorders NCND, Shanghai 200040, China. FAU - Quan, Chao AU - Quan C AD - Department of Neurology, Huashan Hospital, Fudan University, Shanghai 200040, China; National center for neurological disorders NCND, Shanghai 200040, China. Electronic address: chao_quan@fudan.edu.cn. FAU - Li, Fang AU - Li F AD - National center for neurological disorders NCND, Shanghai 200040, China; Department of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China; Department of Rehabilitation Medicine, Renhe Hospital, Baoshan Branch, Shanghai 200431, China. Electronic address: fangl@fudan.edu.cn. LA - eng PT - Journal Article DEP - 20220305 PL - Netherlands TA - Mult Scler Relat Disord JT - Multiple sclerosis and related disorders JID - 101580247 SB - IM MH - Activities of Daily Living MH - Exercise Therapy MH - Humans MH - *Neuromyelitis Optica/therapy MH - Prospective Studies MH - Spinal Cord OTO - NOTNLM OT - Acute phase OT - Expanded disability status scale OT - Neuromyelitis optica spectrum disorder OT - Rehabilitation exercise EDAT- 2022/03/29 06:00 MHDA- 2022/06/09 06:00 CRDT- 2022/03/28 20:14 PHST- 2021/12/11 00:00 [received] PHST- 2022/01/28 00:00 [revised] PHST- 2022/03/04 00:00 [accepted] PHST- 2022/03/29 06:00 [pubmed] PHST- 2022/06/09 06:00 [medline] PHST- 2022/03/28 20:14 [entrez] AID - S2211-0348(22)00241-3 [pii] AID - 10.1016/j.msard.2022.103726 [doi] PST - ppublish SO - Mult Scler Relat Disord. 2022 May;61:103726. doi: 10.1016/j.msard.2022.103726. Epub 2022 Mar 5.