PMID- 35345568
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220330
IS  - 2213-0071 (Print)
IS  - 2213-0071 (Electronic)
IS  - 2213-0071 (Linking)
VI  - 37
DP  - 2022
TI  - Inhalational injury and use of heparin & N-acetylcysteine nebulization: A case 
      report.
PG  - 101640
LID - 10.1016/j.rmcr.2022.101640 [doi]
LID - 101640
AB  - Inhalational injury to the upper and lower airway occurs due to thermal or 
      chemical irritation causing airway edema, capillary leak, mucin, and fibrin 
      debris forming clots and soot. The use of unfractionated heparin (UFH) 
      nebulization was found to be effective by dissolving airway clots. We report a 
      case of inhalational burn injury where UFH nebulization led to a better outcome. 
      A healthy male was trapped in a residential room during a fire in the building. 
      He sustained facial, neck, upper chest, and left upper extremity burns accounting 
      for 25% of body surface area. He was intubated at the site and started on 
      supportive care. In the surgical intensive care unit, bronchoscopy showed severe 
      tracheobronchial burn injury; a thorough lavage was done, started on UFH and 
      N-acetylcysteine nebulization (NAC). The patient improved, and his trachea was 
      extubated on day 6. In our patient, unfractionated heparin nebulization was 
      beneficial as the patient was extubated early without landing to acute 
      respiratory distress syndrome.
CI  - (c) 2022 The Authors.
FAU - Shaikh, Nissar
AU  - Shaikh N
AD  - Surgical Intensive Care Department, Hamad General Hospital (HGH), Hamad Medical 
      Corporation (HMC), Doha, Qatar.
FAU - Chanda, Arshad H
AU  - Chanda AH
AD  - Surgical Intensive Care Department, Hamad General Hospital (HGH), Hamad Medical 
      Corporation (HMC), Doha, Qatar.
FAU - Rahman, Mohammad A
AU  - Rahman MA
AD  - Surgical Intensive Care Department, Hamad General Hospital (HGH), Hamad Medical 
      Corporation (HMC), Doha, Qatar.
FAU - Nainthramveetil, Mohammed M
AU  - Nainthramveetil MM
AD  - Surgical Intensive Care Department, Hamad General Hospital (HGH), Hamad Medical 
      Corporation (HMC), Doha, Qatar.
FAU - Kumar, Ashish
AU  - Kumar A
AD  - Surgical Intensive Care Department, Hamad General Hospital (HGH), Hamad Medical 
      Corporation (HMC), Doha, Qatar.
FAU - Mathias, Ranjan M
AU  - Mathias RM
AD  - Surgical Intensive Care Department, Hamad General Hospital (HGH), Hamad Medical 
      Corporation (HMC), Doha, Qatar.
FAU - Nashwan, Abdulqadir J
AU  - Nashwan AJ
AD  - Nursing Department, Hazm Mebaireek General Hospital (HMGH), Hamad Medical 
      Corporation (HMC), Doha, Qatar.
LA  - eng
PT  - Case Reports
DEP - 20220322
PL  - England
TA  - Respir Med Case Rep
JT  - Respiratory medicine case reports
JID - 101604463
PMC - PMC8956813
OTO - NOTNLM
OT  - Burn injury
OT  - ETT, endotracheal tube
OT  - Inhalational injury
OT  - N-acetylcysteine (NAC)
OT  - NAC, N-acetylcysteine
OT  - SICU, surgical intensive care unit
OT  - Tracheobronchial injury
OT  - UFH, unfractionated heparin
OT  - Unfractionated heparin
COIS- The authors declare that they have no known competing financial interests or 
      personal relationships that could have appeared to influence the work reported in 
      this paper.
EDAT- 2022/03/30 06:00
MHDA- 2022/03/30 06:01
PMCR- 2022/03/22
CRDT- 2022/03/29 05:09
PHST- 2022/01/20 00:00 [received]
PHST- 2022/03/08 00:00 [revised]
PHST- 2022/03/17 00:00 [accepted]
PHST- 2022/03/29 05:09 [entrez]
PHST- 2022/03/30 06:00 [pubmed]
PHST- 2022/03/30 06:01 [medline]
PHST- 2022/03/22 00:00 [pmc-release]
AID - S2213-0071(22)00062-4 [pii]
AID - 101640 [pii]
AID - 10.1016/j.rmcr.2022.101640 [doi]
PST - epublish
SO  - Respir Med Case Rep. 2022 Mar 22;37:101640. doi: 10.1016/j.rmcr.2022.101640. 
      eCollection 2022.