PMID- 35345627
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220330
IS  - 2212-4268 (Print)
IS  - 2212-4276 (Electronic)
IS  - 2212-4268 (Linking)
VI  - 12
IP  - 2
DP  - 2022 Mar-Apr
TI  - Analysing adipokine Omentin-1 in periodontal disease and type-2 diabetes 
      mellitus: An interventional comparative study.
PG  - 273-278
LID - 10.1016/j.jobcr.2022.03.010 [doi]
AB  - BACKGROUND AND OBJECTIVE: Omentin-1 is an anti-inflammatory adipokine associated 
      with metabolic disorders including insulin resistance, glucose intolerance and 
      type 2 diabetes mellitus (T2DM). Diabetes is a crucial systemic risk factor for 
      occurrence of periodontitis. Periodontitis is deliberated as a complication of 
      diabetes. This study aimed to estimate salivary and serum levels of Omentin-1 in 
      chronic periodontitis with or without diabetes mellitus before and after scaling 
      and root planing (SRP) and also the level of glycemic control. MATERIALS AND 
      METHODS: Based on history and clinical parameters, 70 subjects were allocated 
      into two groups i.e. chronic periodontitis (Group 1) and chronic periodontitis 
      with well controlled T2DM (Group 2). Baseline saliva and serum samples were 
      collected from both groups followed by full mouth SRP. Subjects were recalled 3 
      months post SRP for salivary and serum sample collection and measurement of 
      clinical parameters. Serum as well as salivary samples collected were further 
      analysed using enzyme-linked immunosorbent assay to determine the Omentin-1 
      concentration in each sample. RESULTS: The levels of Omentin-1 in saliva and 
      serum were significantly lower in both the groups at baseline. Clinical 
      parameters exhibited a significant reduction 3 months post SRP in both groups. 
      Salivary and serum Omentin-1 levels significantly increased in both the groups, 3 
      months post SRP. HbA1c levels also reduced significantly post therapy. 
      CONCLUSION: A significant relation exists between salivary and serum Omentin-1 in 
      chronic periodontitis and chronic periodontitis with T2DM. In consequence, 
      Omentin-1 level can have possible application as inflammatory marker of T2DM, 
      periodontal disease and treatment outcome.
CI  - (c) 2022 Craniofacial Research Foundation. Published by Elsevier B.V. All rights 
      reserved.
FAU - Dooxa Nongrum, Avexilla
AU  - Dooxa Nongrum A
AD  - Department of Periodontics, Vydehi Institute of Dental Sciences and Research 
      Centre, Whitefield, Bangalore, 560066, Karnataka, India.
FAU - Guru, Sanjeela R
AU  - Guru SR
AD  - Department of Periodontics, Vydehi Institute of Dental Sciences and Research 
      Centre, Whitefield, Bangalore, 560066, Karnataka, India.
FAU - K J, Nisha
AU  - K J N
AD  - Department of Periodontics, Vydehi Institute of Dental Sciences and Research 
      Centre, Whitefield, Bangalore, 560066, Karnataka, India.
FAU - Aghanashini, Suchetha
AU  - Aghanashini S
AD  - Department of Periodontics, DA Pandu Memorial R V Dental College and Hospital, 
      J.P. Nagar, Bangalore, 560078, Karnataka, India.
LA  - eng
PT  - Journal Article
DEP - 20220319
PL  - Netherlands
TA  - J Oral Biol Craniofac Res
JT  - Journal of oral biology and craniofacial research
JID - 101619156
PMC - PMC8956812
OTO - NOTNLM
OT  - Adipokines
OT  - Chronic periodontitis
OT  - Diabetes mellitus
OT  - Glycated hemoglobin A
OT  - Insulin resistance
OT  - Omentin-1
COIS- The authors have no conflicts of interest to declare that are relevant to the 
      content of this article.The authors have no relevant financial or non-financial 
      interests to disclose.
EDAT- 2022/03/30 06:00
MHDA- 2022/03/30 06:01
PMCR- 2022/03/19
CRDT- 2022/03/29 05:11
PHST- 2021/04/08 00:00 [received]
PHST- 2021/07/16 00:00 [revised]
PHST- 2022/03/18 00:00 [accepted]
PHST- 2022/03/29 05:11 [entrez]
PHST- 2022/03/30 06:00 [pubmed]
PHST- 2022/03/30 06:01 [medline]
PHST- 2022/03/19 00:00 [pmc-release]
AID - S2212-4268(22)00020-3 [pii]
AID - 10.1016/j.jobcr.2022.03.010 [doi]
PST - ppublish
SO  - J Oral Biol Craniofac Res. 2022 Mar-Apr;12(2):273-278. doi: 
      10.1016/j.jobcr.2022.03.010. Epub 2022 Mar 19.