PMID- 35346535
OWN - NLM
STAT- MEDLINE
DCOM- 20220915
LR  - 20220915
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 83
IP  - 10
DP  - 2022 Oct
TI  - A clinician's guide to HLA matching in allogeneic hematopoietic stem cell 
      transplant.
PG  - 687-694
LID - S0198-8859(22)00053-2 [pii]
LID - 10.1016/j.humimm.2022.03.002 [doi]
AB  - Human leukocyte antigen (HLA) matching is an essential component of allogeneic 
      hematopoietic stem cell transplant (HSCT). However, for some clinicians the 
      biology underpinning HLA structure and function may be but a distant memory from 
      lectures many years past, and, understanding the complexities of HLA matching can 
      be challenging for clinicians new to the field, particularly as there have been 
      several important advances in the field this past decade. In this review, we 
      provide an up to date resource to educate and remind clinicians of: 1) Why HLA 
      matching matters, including reviewing the role HLA molecules play in the adaptive 
      immune system and the consequences of HLA mismatch. 2) What is involved in HLA 
      matching, including a review of the different HLA genes, HLA protein structure, 
      HLA sequencing approaches through time, and HLA allele nomenclature. And 3) how 
      to apply this knowledge to identify an HLA matched donor for allogeneic HSCT, 
      including discussion regarding HLA-DPB1 permissive mismatching and Donor Specific 
      Antibodies.
CI  - Copyright (c) 2022 American Society for Histocompatibility and Immunogenetics. 
      Published by Elsevier Inc. All rights reserved.
FAU - Mangum, D Spencer
AU  - Mangum DS
AD  - Nemours Children's Health, Nemours Center for Cancer and Blood Disorders, 
      Wilmington, DE, United States. Electronic address: spencer.mangum@nemours.org.
FAU - Caywood, Emi
AU  - Caywood E
AD  - Nemours Children's Health, Nemours Center for Cancer and Blood Disorders, 
      Wilmington, DE, United States.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220325
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Antibodies)
SB  - IM
MH  - Antibodies
MH  - *Graft vs Host Disease/genetics
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Histocompatibility Testing
MH  - Humans
MH  - Immunologic Tests
MH  - Unrelated Donors
OTO - NOTNLM
OT  - HLA
OT  - HSCT
OT  - Match
OT  - Transplant
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2022/03/30 06:00
MHDA- 2022/09/16 06:00
CRDT- 2022/03/29 05:42
PHST- 2021/11/20 00:00 [received]
PHST- 2022/02/14 00:00 [revised]
PHST- 2022/03/02 00:00 [accepted]
PHST- 2022/03/30 06:00 [pubmed]
PHST- 2022/09/16 06:00 [medline]
PHST- 2022/03/29 05:42 [entrez]
AID - S0198-8859(22)00053-2 [pii]
AID - 10.1016/j.humimm.2022.03.002 [doi]
PST - ppublish
SO  - Hum Immunol. 2022 Oct;83(10):687-694. doi: 10.1016/j.humimm.2022.03.002. Epub 
      2022 Mar 25.