PMID- 35347028 OWN - NLM STAT- MEDLINE DCOM- 20220404 LR - 20220531 IS - 1791-7530 (Electronic) IS - 0250-7005 (Linking) VI - 42 IP - 4 DP - 2022 Apr TI - Usefulness of Medication Guidance Sheets for Patients With Non-Hodgkin's Lymphoma Receiving ESHAP+/-R Therapy. PG - 2053-2060 LID - 10.21873/anticanres.15686 [doi] AB - BACKGROUND/AIM: The occurrence of chemotherapy-related serious adverse events (AEs) is associated with a poor prognosis of hematopoietic malignancies. We have developed a medication guidance sheet (MGS) for monitoring AEs occurring when combining chemotherapy with etoposide, methylprednisolone, cisplatin, cytarabine, and rituximab (ESHAP+/-R). In this study, the usefulness of MGS was investigated in non-Hodgkin's lymphoma patients. PATIENTS AND METHODS: The MGS was used to monitor AEs in 48 adult patients receiving ESHAP+/-R. The prediction accuracy of the MGS was estimated before and after modification based on practical data. RESULTS: A total of 246 AEs developed, all of which were predicted by the MGS. Among them, 149 events (61%) occurred during the same period as those predicted by the MGS. After modification of MGS for the onset and duration of AEs, the accuracy increased to 84%. CONCLUSION: The accuracy of the original MGS for ESHAP+/-R was insufficient but greatly improved after the AEs duration modification. CI - Copyright (c) 2022 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved. FAU - Uchida, Mayako AU - Uchida M AD - Education and Research Center for Clinical Pharmacy, Osaka University of Pharmaceutical Sciences, Osaka, Japan; m-uchida@dwc.doshisha.ac.jp. AD - Department of Education and Research Center for Pharmacy Practice, Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Kyoto, Japan. FAU - Murata, Saeko AU - Murata S AD - Department of Education and Research Center for Pharmacy Practice, Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Kyoto, Japan. FAU - Morikawa, Hanae AU - Morikawa H AD - Department of Pharmacy, Kyushu University Hospital, Fukuoka, Japan. FAU - Yonemitsu, Hiroko AU - Yonemitsu H AD - Department of Pharmacy, Kyushu University Hospital, Fukuoka, Japan. FAU - Ishida, Shigeru AU - Ishida S AD - Department of Pharmacy, Kyushu University Hospital, Fukuoka, Japan. FAU - Suetsugu, Kimitaka AU - Suetsugu K AD - Department of Pharmacy, Kyushu University Hospital, Fukuoka, Japan. FAU - Tsuji, Toshikazu AU - Tsuji T AD - Department of Pharmacy, Kyushu University Hospital, Fukuoka, Japan. FAU - Watanabe, Hiroyuki AU - Watanabe H AD - Department of Pharmacy, Kyushu University Hospital, Fukuoka, Japan. AD - Department of Pharmacy, Fukuoka Tokushukai Hospital, Fukuoka, Japan. FAU - Kawashiri, Takehiro AU - Kawashiri T AD - Department of Clinical Pharmacy and Pharmaceutical Care, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan. FAU - Kato, Koji AU - Kato K AD - Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan. FAU - Hosohata, Keiko AU - Hosohata K AD - Education and Research Center for Clinical Pharmacy, Osaka University of Pharmaceutical Sciences, Osaka, Japan. FAU - Miyamoto, Toshihiro AU - Miyamoto T AD - Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan. FAU - Egashira, Nobuaki AU - Egashira N AD - Department of Pharmacy, Kyushu University Hospital, Fukuoka, Japan. FAU - Nakamura, Tsutomu AU - Nakamura T AD - Education and Research Center for Clinical Pharmacy, Osaka University of Pharmaceutical Sciences, Osaka, Japan. FAU - Akashi, Koichi AU - Akashi K AD - Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan. FAU - Ieiri, Ichiro AU - Ieiri I AD - Department of Pharmacy, Kyushu University Hospital, Fukuoka, Japan. LA - eng PT - Journal Article PL - Greece TA - Anticancer Res JT - Anticancer research JID - 8102988 RN - 04079A1RDZ (Cytarabine) RN - 6PLQ3CP4P3 (Etoposide) RN - Q20Q21Q62J (Cisplatin) RN - X4W7ZR7023 (Methylprednisolone) SB - IM EIN - Anticancer Res. 2022 Jun;42(6):3231-3232. PMID: 35641303 MH - Adult MH - *Cisplatin/adverse effects MH - Cytarabine/adverse effects MH - Etoposide/adverse effects MH - Humans MH - *Lymphoma, Non-Hodgkin/drug therapy MH - Methylprednisolone/therapeutic use OTO - NOTNLM OT - Chemotherapy OT - ESHAP+/-R therapy OT - adverse events OT - medication guidance sheet OT - non-Hodgkin's lymphoma EDAT- 2022/03/30 06:00 MHDA- 2022/04/05 06:00 CRDT- 2022/03/29 05:44 PHST- 2022/01/16 00:00 [received] PHST- 2022/03/09 00:00 [revised] PHST- 2022/03/10 00:00 [accepted] PHST- 2022/03/29 05:44 [entrez] PHST- 2022/03/30 06:00 [pubmed] PHST- 2022/04/05 06:00 [medline] AID - 42/4/2053 [pii] AID - 10.21873/anticanres.15686 [doi] PST - ppublish SO - Anticancer Res. 2022 Apr;42(4):2053-2060. doi: 10.21873/anticanres.15686.