PMID- 35347534
OWN - NLM
STAT- MEDLINE
DCOM- 20221115
LR  - 20230104
IS  - 1573-2568 (Electronic)
IS  - 0163-2116 (Linking)
VI  - 67
IP  - 12
DP  - 2022 Dec
TI  - Patient-Predicted Outcomes Are Associated with Quality of Life in Patients with 
      Primary Sclerosing Cholangitis.
PG  - 5483-5492
LID - 10.1007/s10620-022-07482-z [doi]
AB  - BACKGROUND: Primary sclerosing cholangitis (PSC) is a chronic, progressive liver 
      disease, and many patients ultimately require liver transplantation (LT). PSC 
      also confers an increased risk of malignancies, including cholangiocarcinoma 
      (CCA) and colorectal cancer. AIMS: This study aimed to evaluate patient-perceived 
      outcomes and the extent to which these impact health-related quality of life 
      (HRQoL). METHODS: Patients with PSC completed a risk perception questionnaire, 
      the Short Form-36 (SF-36), and the Chronic Liver Disease Questionnaire. 
      Multivariable models were used to determine factors associated with 
      patient-perceived risks of malignancy, LT, and life expectancy, as well as their 
      relationship with HRQoL scores. RESULTS: A total of 95 patients completed the 
      risk perception questionnaire, and 73 returned the remaining instruments. The 
      estimated risks varied widely. Half overestimated their one-year or lifetime CCA 
      risk, while some predicted zero chance. Predicted LT risk was the only outcome 
      concordant with disease severity. Pruritus was associated with higher predicted 
      one-year risks and lower life expectancy. Lifetime CCA and LT risks were 
      associated with the SF-36 physical component score, while perceived life 
      expectancy was strongly associated with mental health domains, including the 
      SF-36 mental component score. CONCLUSIONS: Predicted prognosis varies widely 
      among patients with PSC and is influenced more by symptoms than objective disease 
      severity. The psychological burden of shorter perceived life expectancy impacts 
      mental HRQoL more than the risks of malignancy or LT. These findings highlight an 
      opportunity for improved patient communication regarding these outcomes, as well 
      as the importance of discussing them, as they may impact HRQoL.
CI  - (c) 2022. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Henson, Jacqueline B
AU  - Henson JB
AUID- ORCID: 0000-0003-3488-6615
AD  - Division of Gastroenterology, Department of Medicine, Duke University School of 
      Medicine, DUMC 3913, Durham, NC, 27710, USA. jackie.henson@duke.edu.
FAU - Helzberg, James H
AU  - Helzberg JH
AD  - Department of Medicine, Duke University School of Medicine, Durham, NC, USA.
FAU - Muir, Andrew J
AU  - Muir AJ
AD  - Division of Gastroenterology, Department of Medicine, Duke University School of 
      Medicine and Duke Clinical Research Institute, Durham, NC, USA.
LA  - eng
PT  - Journal Article
DEP - 20220328
PL  - United States
TA  - Dig Dis Sci
JT  - Digestive diseases and sciences
JID - 7902782
SB  - IM
MH  - Humans
MH  - Quality of Life
MH  - *Cholangitis, Sclerosing/complications
MH  - *Cholangiocarcinoma/diagnosis
MH  - *Liver Diseases/complications
MH  - Bile Ducts, Intrahepatic/pathology
MH  - *Bile Duct Neoplasms/complications
OTO - NOTNLM
OT  - Cholangitis, sclerosing
OT  - Prognosis
OT  - Quality of life
OT  - Surveys and questionnaires
EDAT- 2022/03/30 06:00
MHDA- 2022/11/16 06:00
CRDT- 2022/03/29 05:48
PHST- 2022/01/05 00:00 [received]
PHST- 2022/03/07 00:00 [accepted]
PHST- 2022/03/30 06:00 [pubmed]
PHST- 2022/11/16 06:00 [medline]
PHST- 2022/03/29 05:48 [entrez]
AID - 10.1007/s10620-022-07482-z [pii]
AID - 10.1007/s10620-022-07482-z [doi]
PST - ppublish
SO  - Dig Dis Sci. 2022 Dec;67(12):5483-5492. doi: 10.1007/s10620-022-07482-z. Epub 
      2022 Mar 28.