PMID- 35349360
OWN - NLM
STAT- MEDLINE
DCOM- 20230308
LR  - 20230422
IS  - 1097-6817 (Electronic)
IS  - 0194-5998 (Linking)
VI  - 168
IP  - 2
DP  - 2023 Feb
TI  - Long-Term Quality of Life of Vestibular Schwannoma Patients: A Longitudinal 
      Analysis.
PG  - 210-217
LID - 10.1177/01945998221088565 [doi]
AB  - OBJECTIVE: Vestibular schwannoma management aims to maintain optimal quality of 
      life (QoL) while preventing severe sequelae of the tumor or its treatment. This 
      study assessed long-term QoL of patients with vestibular schwannoma in relation 
      to treatment modality and decisional regret. STUDY DESIGN: A longitudinal study, 
      in which clinical and QoL data were used that were cross-sectionally acquired in 
      2014 and again in 2020 from the same patient group. SETTING: A tertiary expert 
      center for vestibular schwannoma care in the Netherlands. METHODS: QoL was 
      measured by the Penn Acoustic Quality of Life (PANQOL) scale. Changes in time 
      were assed using a linear mixed model. In addition, the Decision Regret Scale was 
      analyzed. RESULTS: Of 867 patients, 536 responded (62%), with a median follow-up 
      of 11 years. All PANQOL subdomain scores remained stable over time and did not 
      exceed minimal clinically important difference (MCID) levels. Time since 
      treatment did not affect QoL. Patients had comparable average QoL scores and 
      proportions of patients with changing QoL scores (ie, exceeding the MCID) over 
      time, irrespective of the received initial treatment. Female patients and those 
      who required salvage therapy (either by radiotherapy or surgery) reported a lower 
      QoL. The latter patient group reported the highest decisional regret. CONCLUSION: 
      On average, the long-term QoL of patients with vestibular schwannoma is 
      comparable for patients under active surveillance and those who have received 
      active treatment, and it remains stable over time. This suggests that, on 
      average, preservation of QoL of patients with vestibular schwannoma is feasible 
      when adequately managed.
CI  - (c) 2022 The Authors. Otolaryngology-Head and Neck Surgery published by Wiley 
      Periodicals LLC on behalf of American Academy of Otolaryngology-Head and Neck 
      Surgery Foundation.
FAU - Neve, Olaf M
AU  - Neve OM
AUID- ORCID: 0000-0002-5104-8448
AD  - Department of Otorhinolaryngology and Head & Neck Surgery, Leiden University 
      Medical Center, Leiden, South Holland, The Netherlands.
FAU - Jansen, Jeroen C
AU  - Jansen JC
AD  - Department of Otorhinolaryngology and Head & Neck Surgery, Leiden University 
      Medical Center, Leiden, South Holland, The Netherlands.
FAU - Koot, Radboud W
AU  - Koot RW
AD  - Department of Neurosurgery, Leiden University Medical Center, Leiden, South 
      Holland, The Netherlands.
FAU - Ridder, Mischa de
AU  - Ridder M
AD  - Department of Radiation Oncology, Leiden University Medical Center, Leiden, South 
      Holland, The Netherlands.
FAU - Paul G van Benthem, Peter
AU  - Paul G van Benthem P
AD  - Department of Otorhinolaryngology and Head & Neck Surgery, Leiden University 
      Medical Center, Leiden, South Holland, The Netherlands.
FAU - Stiggelbout, Anne M
AU  - Stiggelbout AM
AD  - Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, 
      South Holland, The Netherlands.
FAU - Hensen, Erik F
AU  - Hensen EF
AD  - Department of Otorhinolaryngology and Head & Neck Surgery, Leiden University 
      Medical Center, Leiden, South Holland, The Netherlands.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Otolaryngol Head Neck Surg
JT  - Otolaryngology--head and neck surgery : official journal of American Academy of 
      Otolaryngology-Head and Neck Surgery
JID - 8508176
SB  - IM
MH  - Humans
MH  - Female
MH  - *Quality of Life
MH  - *Neuroma, Acoustic/surgery
MH  - Longitudinal Studies
MH  - Cross-Sectional Studies
MH  - Emotions
OTO - NOTNLM
OT  - long-term
OT  - quality of life
OT  - radiotherapy
OT  - surgery
OT  - vestibular schwannoma
EDAT- 2022/03/30 06:00
MHDA- 2023/03/09 06:00
CRDT- 2022/03/29 17:11
PHST- 2022/01/21 00:00 [received]
PHST- 2022/03/03 00:00 [accepted]
PHST- 2022/03/30 06:00 [pubmed]
PHST- 2023/03/09 06:00 [medline]
PHST- 2022/03/29 17:11 [entrez]
AID - 10.1177/01945998221088565 [doi]
PST - ppublish
SO  - Otolaryngol Head Neck Surg. 2023 Feb;168(2):210-217. doi: 
      10.1177/01945998221088565.