PMID- 35349731
OWN - NLM
STAT- MEDLINE
DCOM- 20220517
LR  - 20220716
IS  - 1098-2825 (Electronic)
IS  - 0887-8013 (Print)
IS  - 0887-8013 (Linking)
VI  - 36
IP  - 5
DP  - 2022 May
TI  - Circulating microRNAs as predictive biomarkers of coronary artery diseases in 
      type 2 diabetes patients.
PG  - e24380
LID - 10.1002/jcla.24380 [doi]
LID - e24380
AB  - BACKGROUND: Type 2 diabetes mellitus (T2DM) is an increasing metabolic disorder 
      mostly resulting from unhealthy lifestyles. T2DM patients are prone to develop 
      heart conditions such as coronary artery disease (CAD) which is a major cause of 
      death in the world. Most clinical symptoms emerge at the advanced stages of CAD; 
      therefore, establishing new biomarkers detectable in the early stages of the 
      disease is crucial to enhance the efficiency of treatment. Recently, a 
      significant body of evidence has shown alteration in miRNA levels associate with 
      dysregulated gene expression occurring in T2DM and CAD, highlighting significance 
      of circulating miRNAs in early detection of CAD arising from T2DM. Therefore, it 
      seems crucial to establish a link between the miRNAs prognosing value and 
      development of CAD in T2DM. AIM: This study provides an overview on the 
      alterations of the circulatory miRNAs in T2DM and various CADs and consider the 
      potentials of miRNAs as biomarkers prognosing CADs in T2DM patients. MATERIALS 
      AND METHODS: Literature search was conducted for miRNAs involved in development 
      of T2DM and CAD using the following key words: "miRNAs", "Biomarker", "Diabetes 
      Mellitus Type 2 (T2DM)", "coronary artery diseases (CAD)". Articles written in 
      the English language. RESULT: There has been shown a rise in miR-375, miR-9, 
      miR-30a-5p, miR-150, miR-9, miR-29a, miR-30d, miR-34a, miR-124a, miR-146a, 
      miR-27a, and miR-320a in T2DM; whereas, miR-126, miR-21, miR-103, miR-28-3p, 
      miR-15a, miR-145, miR-375, miR-223 have been shown to decrease. In addition to 
      T2DM, some miRNAs such as mirR-1, miR-122, miR-132, and miR-133 play a part in 
      development of subclinical aortic atherosclerosis associated with metabolic 
      syndrome. Some miRNAs increase in both T2DM and CAD such as miR-1, miR-132, 
      miR-133, and miR-373-3-p. More interestingly, some of these miRNAs such as 
      miR-92a elevate years before emerging CAD in T2DM. CONCLUSION: dysregulation of 
      miRNAs plays outstanding roles in development of T2DM and CAD. Also, elevation of 
      some miRNAs such as miR-92a in T2DM patients can efficiently prognose development 
      of CAD in these patients, so these miRNAs can be used as biomarkers in this 
      regard.
CI  - (c) 2022 The Authors. Journal of Clinical Laboratory Analysis published by Wiley 
      Periodicals LLC.
FAU - Mahjoob, Golnoosh
AU  - Mahjoob G
AUID- ORCID: 0000-0002-9341-2666
AD  - Department of Clinical Biochemistry, Sarab Faculty of Medical Sciences., Sarab, 
      Iran.
AD  - Department of Clinical Biochemistry, Tarbiat Modares University, Tehran, Iran.
FAU - Ahmadi, Yasin
AU  - Ahmadi Y
AUID- ORCID: 0000-0001-6721-1775
AD  - Department of Medical Laboratory Sciences, College of Science, Komar University 
      of Science and Technology, Sulaimani, Iraq.
FAU - Fatima Rajani, Huda
AU  - Fatima Rajani H
AUID- ORCID: 0000-0001-9764-2154
AD  - Department of medical biotechnology, School of advanced sciences in medicine, 
      Tehran University of medical sciences, Tehran, Iran.
FAU - Khanbabaei, Nafiseh
AU  - Khanbabaei N
AUID- ORCID: 0000-0003-4960-7295
AD  - Department of Clinical Biochemistry, Sarab Faculty of Medical Sciences., Sarab, 
      Iran.
AD  - Department of Clinical Biochemistry, Tarbiat Modares University, Tehran, Iran.
FAU - Abolhasani, Sakhavat
AU  - Abolhasani S
AUID- ORCID: 0000-0001-9888-7508
AD  - Department of Clinical Biochemistry, Sarab Faculty of Medical Sciences., Sarab, 
      Iran.
AD  - Department of Clinical Biochemistry, Tarbiat Modares University, Tehran, Iran.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220329
PL  - United States
TA  - J Clin Lab Anal
JT  - Journal of clinical laboratory analysis
JID - 8801384
RN  - 0 (Biomarkers)
RN  - 0 (Circulating MicroRNA)
RN  - 0 (MicroRNAs)
SB  - IM
MH  - Biomarkers
MH  - *Circulating MicroRNA/genetics
MH  - *Coronary Artery Disease/diagnosis
MH  - *Diabetes Mellitus, Type 2/complications/genetics
MH  - Humans
MH  - *MicroRNAs/genetics
PMC - PMC9102494
OTO - NOTNLM
OT  - biomarker
OT  - coronary artery diseases (CAD)
OT  - diabetes mellitus type 2 (T2DM)
OT  - microRNAs
COIS- The authors declare no conflict of interest.
EDAT- 2022/03/30 06:00
MHDA- 2022/05/18 06:00
PMCR- 2022/03/29
CRDT- 2022/03/29 17:13
PHST- 2022/03/16 00:00 [revised]
PHST- 2022/01/10 00:00 [received]
PHST- 2022/03/17 00:00 [accepted]
PHST- 2022/03/30 06:00 [pubmed]
PHST- 2022/05/18 06:00 [medline]
PHST- 2022/03/29 17:13 [entrez]
PHST- 2022/03/29 00:00 [pmc-release]
AID - JCLA24380 [pii]
AID - 10.1002/jcla.24380 [doi]
PST - ppublish
SO  - J Clin Lab Anal. 2022 May;36(5):e24380. doi: 10.1002/jcla.24380. Epub 2022 Mar 
      29.