PMID- 35350291
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220401
IS  - 1662-680X (Print)
IS  - 1662-680X (Electronic)
IS  - 1662-680X (Linking)
VI  - 14
IP  - 1
DP  - 2022 Jan-Apr
TI  - Progressive Multifocal Leukoencephalopathy and Immune Reconstitution Inflammatory 
      Syndrome after Discontinuation of Fingolimod.
PG  - 38-43
LID - 10.1159/000521944 [doi]
AB  - Progressive multifocal leukoencephalopathy (PML) is a rare complication of 
      immunosuppressive treatment in MS patients. Immune reconstitution inflammatory 
      syndrome (IRIS) appears after the withdrawal of certain drugs such as natalizumab 
      (NTZ) or fingolimod. The development of PML-IRIS after NTZ treatment has been 
      described, and its diagnosis is made by clinical and radiological criteria and 
      the determination of the John Cunningham virus in CSF. We present a clinical case 
      of a patient with MS who, after the withdrawal of fingolimod, developed PML-IRIS 
      despite sustained lymphopenia. This is important for pharmacovigilance purposes, 
      not only for NTZ but also for alternative drugs used in MS treatment.
CI  - Copyright (c) 2022 by S. Karger AG, Basel.
FAU - Pinar Morales, Raquel
AU  - Pinar Morales R
AD  - Servicio de Neurologia, Hospital Clinico Universitario San Cecilio, Granada, 
      Spain.
AD  - Departamento Medicina, Universidad de Granada, Granada, Spain.
FAU - Carrasco Garcia, Maria
AU  - Carrasco Garcia M
AD  - Servicio de Neurologia, Hospital Clinico Universitario San Cecilio, Granada, 
      Spain.
FAU - Gutierrez-Rojas, Luis
AU  - Gutierrez-Rojas L
AD  - Departamento Medicina, Universidad de Granada, Granada, Spain.
AD  - Unidad de Salud Mental, Hospital Clinico Universitario San Cecilio, Granada, 
      Spain.
FAU - Barrero Hernandez, Francisco Javier
AU  - Barrero Hernandez FJ
AD  - Servicio de Neurologia, Hospital Clinico Universitario San Cecilio, Granada, 
      Spain.
AD  - Departamento Medicina, Universidad de Granada, Granada, Spain.
LA  - eng
PT  - Case Reports
DEP - 20220207
PL  - Switzerland
TA  - Case Rep Neurol
JT  - Case reports in neurology
JID - 101517693
PMC - PMC8921886
OTO - NOTNLM
OT  - Fingolimod
OT  - Immune reconstitution inflammatory syndrome
OT  - Magnetic resonance imaging
OT  - Multiple sclerosis
OT  - Progressive multifocal leukoencephalopathy
COIS- The author declares that the research was conducted in the absence of any 
      commercial or financial relationships that could represent a potential conflict 
      of interest.
EDAT- 2022/03/31 06:00
MHDA- 2022/03/31 06:01
PMCR- 2022/02/07
CRDT- 2022/03/30 05:07
PHST- 2021/11/08 00:00 [received]
PHST- 2022/01/05 00:00 [accepted]
PHST- 2022/03/30 05:07 [entrez]
PHST- 2022/03/31 06:00 [pubmed]
PHST- 2022/03/31 06:01 [medline]
PHST- 2022/02/07 00:00 [pmc-release]
AID - crn-0014-0038 [pii]
AID - 10.1159/000521944 [doi]
PST - epublish
SO  - Case Rep Neurol. 2022 Feb 7;14(1):38-43. doi: 10.1159/000521944. eCollection 2022 
      Jan-Apr.