PMID- 35350431
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220401
IS  - 1662-5099 (Print)
IS  - 1662-5099 (Electronic)
IS  - 1662-5099 (Linking)
VI  - 15
DP  - 2022
TI  - Role of Semaphorins in Ischemic Stroke.
PG  - 848506
LID - 10.3389/fnmol.2022.848506 [doi]
LID - 848506
AB  - Ischemic stroke is one of the major causes of neurological morbidity and 
      mortality in the world. Although the management of ischemic stroke has been 
      improved significantly, it still imposes a huge burden on the health and 
      property. The integrity of the neurovascular unit (NVU) is closely related with 
      the prognosis of ischemic stroke. Growing evidence has shown that semaphorins, a 
      family of axon guidance cues, play a pivotal role in multiple pathophysiological 
      processes in NVU after ischemia, such as regulating the immune system, 
      angiogenesis, and neuroprotection. Modulating the NVU function via semaphorin 
      signaling has a potential to develop a novel therapeutic strategy for ischemic 
      stroke. We, therefore, review recent progresses on the role of semphorin family 
      members in neurons, glial cells and vasculature after ischemic stroke.
CI  - Copyright (c) 2022 Du, Xu and Zhu.
FAU - Du, Huaping
AU  - Du H
AD  - Department of Neurology, Suzhou Ninth Hospital Affiliated to Soochow University, 
      Suzhou, China.
FAU - Xu, Yuan
AU  - Xu Y
AD  - Department of Neurology, Suzhou Ninth Hospital Affiliated to Soochow University, 
      Suzhou, China.
FAU - Zhu, Li
AU  - Zhu L
AD  - Department of Neurology, Suzhou Ninth Hospital Affiliated to Soochow University, 
      Suzhou, China.
AD  - Suzhou Key Laboratory of Thrombosis and Vascular Biology, Jiangsu Key Laboratory 
      of Preventive and Translational Medicine for Geriatric Diseases, Collaborative 
      Innovation Center of Hematology of Jiangsu Province, National Clinical Research 
      Center for Hematologic Diseases, Cyrus Tang Medical Institute, Soochow 
      University, Suzhou, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220308
PL  - Switzerland
TA  - Front Mol Neurosci
JT  - Frontiers in molecular neuroscience
JID - 101477914
PMC - PMC8957939
OTO - NOTNLM
OT  - glial cells
OT  - ischemic stroke
OT  - neurons
OT  - neurovascular unit
OT  - semaphorins
OT  - vasculature
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/03/31 06:00
MHDA- 2022/03/31 06:01
PMCR- 2022/01/01
CRDT- 2022/03/30 05:09
PHST- 2022/01/04 00:00 [received]
PHST- 2022/02/17 00:00 [accepted]
PHST- 2022/03/30 05:09 [entrez]
PHST- 2022/03/31 06:00 [pubmed]
PHST- 2022/03/31 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fnmol.2022.848506 [doi]
PST - epublish
SO  - Front Mol Neurosci. 2022 Mar 8;15:848506. doi: 10.3389/fnmol.2022.848506. 
      eCollection 2022.