PMID- 35351455
OWN - NLM
STAT- MEDLINE
DCOM- 20220620
LR  - 20220728
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Linking)
VI  - 212
IP  - Pt A
DP  - 2022 Sep
TI  - Co-exposure to multiple air pollutants and sleep disordered breathing in patients 
      with or without obstructive sleep apnea: A cross-sectional study.
PG  - 113155
LID - S0013-9351(22)00482-0 [pii]
LID - 10.1016/j.envres.2022.113155 [doi]
AB  - BACKGROUND: Air pollution may be a contributing risk factor for obstructive sleep 
      apnea (OSA). However, the health effects of co-exposure to multiple air 
      pollutants on OSA patients remain unclear. OBJECTIVES: To assess the joint effect 
      of multi-pollutant on sleep disordered breathing (SDB) parameters in patients 
      with or without OSA and identify the dominant pollutants. METHODS: A total of 
      2524 outpatients from April 2020 to May 2021 were recruited in this 
      cross-sectional study. Ambient air pollutant data were obtained from the nearest 
      central monitoring stations to participants' residential address. SDB parameters 
      were measured by the ApneaLink devices, including apnea-hypopnea index (AHI), 
      hypopnea index (HI), oxygen desaturation index (ODI), average oxygen saturation 
      (SpO(2)), percentage sleep time with <90% saturation (T90), and desaturation. 
      Bayesian kernel machine regression (BKMR) was applied to evaluate the effects of 
      multiple pollutants. RESULTS: Significant associations were observed between air 
      pollutants and SDB parameters (including increases in AHI, HI, ODI, and 
      desaturation) among patients with OSA. Co-exposure to air pollutants was 
      positively correlated with AHI, HI, and ODI. PM(10) and O(3) dominated the 
      effects of pollutant mixtures on OSA, with the highest posterior inclusion 
      probability (PIP) values of 0.592 and 0.640, respectively. Stratified analysis 
      showed that, compared to male patients with OSA, stronger effects on the SDB 
      parameters were observed in female patients. Stronger associations were also 
      found in the warm season than those in the cold season. CONCLUSION: Co-exposure 
      to air pollutants was associated with SDB parameters among patients with OSA, 
      PM(10) and O(3) might play the dominant roles.
CI  - Copyright (c) 2022 Elsevier Inc. All rights reserved.
FAU - Wang, Junyi
AU  - Wang J
AD  - Department of Occupational and Environmental Health Sciences, School of Public 
      Health, Peking University, Beijing, 100191, China.
FAU - Wang, Wanzhou
AU  - Wang W
AD  - Department of Occupational and Environmental Health Sciences, School of Public 
      Health, Peking University, Beijing, 100191, China.
FAU - Zhang, Wenlou
AU  - Zhang W
AD  - Department of Occupational and Environmental Health Sciences, School of Public 
      Health, Peking University, Beijing, 100191, China.
FAU - Wang, Jianli
AU  - Wang J
AD  - Department of Respiratory Medicine, Peking University Third Hospital, Beijing, 
      100191, China.
FAU - Huang, Yongwei
AU  - Huang Y
AD  - Department of Respiratory Medicine, Peking University Third Hospital, Beijing, 
      100191, China.
FAU - Hu, Zixuan
AU  - Hu Z
AD  - Department of Respiratory Medicine, Peking University Third Hospital, Beijing, 
      100191, China.
FAU - Chen, Yahong
AU  - Chen Y
AD  - Department of Respiratory Medicine, Peking University Third Hospital, Beijing, 
      100191, China.
FAU - Guo, Xinbiao
AU  - Guo X
AD  - Department of Occupational and Environmental Health Sciences, School of Public 
      Health, Peking University, Beijing, 100191, China.
FAU - Deng, Furong
AU  - Deng F
AD  - Department of Occupational and Environmental Health Sciences, School of Public 
      Health, Peking University, Beijing, 100191, China. Electronic address: 
      lotus321321@126.com.
FAU - Zhang, Liqiang
AU  - Zhang L
AD  - Department of Respiratory Medicine, Peking University Third Hospital, Beijing, 
      100191, China. Electronic address: byzlq@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220326
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Air Pollutants)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - *Air Pollutants/adverse effects/analysis
MH  - Bayes Theorem
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Oxygen
MH  - *Sleep Apnea Syndromes/complications/etiology
MH  - *Sleep Apnea, Obstructive/complications/etiology
OTO - NOTNLM
OT  - Air pollution
OT  - Joint effect
OT  - Obstructive sleep apnea
OT  - Sleep disordered breathing
EDAT- 2022/03/31 06:00
MHDA- 2022/06/22 06:00
CRDT- 2022/03/30 05:39
PHST- 2021/10/12 00:00 [received]
PHST- 2022/01/31 00:00 [revised]
PHST- 2022/03/18 00:00 [accepted]
PHST- 2022/03/31 06:00 [pubmed]
PHST- 2022/06/22 06:00 [medline]
PHST- 2022/03/30 05:39 [entrez]
AID - S0013-9351(22)00482-0 [pii]
AID - 10.1016/j.envres.2022.113155 [doi]
PST - ppublish
SO  - Environ Res. 2022 Sep;212(Pt A):113155. doi: 10.1016/j.envres.2022.113155. Epub 
      2022 Mar 26.