PMID- 35351746
OWN - NLM
STAT- MEDLINE
DCOM- 20220331
LR  - 20240330
IS  - 1757-790X (Electronic)
IS  - 1757-790X (Linking)
VI  - 15
IP  - 3
DP  - 2022 Mar 29
TI  - Rapidly enlarging pulmonary mass due to immune reconstitution inflammatory 
      syndrome (IRIS) in an immunocompetent host with pulmonary Cryptococcus 
      neoformans.
LID - 10.1136/bcr-2021-247495 [doi]
LID - e247495
AB  - An immunocompetent man presented with Cryptococcus neoformans disease manifesting 
      as a large pulmonary mass (cryptococcoma). Despite an initial induction course of 
      4 weeks of liposomal amphotericin B (LAmB), followed by 8 weeks of fluconazole, 
      the cryptococcoma enlarged in size. Ten days into a second course of induction 
      therapy with LAmB and flucytosine, the cryptococcoma markedly increased in size 
      with encroachment on critical vascular structures. Due to concern for immune 
      reconstitution inflammatory syndrome (IRIS), prednisone was added with 
      significant decrease in the size of the mass. To our knowledge, this is the first 
      reported case of pulmonary cryptococcal-IRIS in an immunocompetent host.
CI  - (c) BMJ Publishing Group Limited 2022. No commercial re-use. See rights and 
      permissions. Published by BMJ.
FAU - Tucker, Mollie
AU  - Tucker M
AD  - Infectious Diseases, Yale University School of Medicine, New Haven, Connecticut, 
      USA mollie.tucker@yale.edu.
FAU - Sheikh, Abdul Majeed
AU  - Sheikh AM
AD  - Infectious Diseases, Charlotte Hungerford Hospital, Torrington, Connecticut, USA.
FAU - Villanueva, Merceditas S
AU  - Villanueva MS
AUID- ORCID: 0000-0003-1022-7746
AD  - Infectious Diseases, Yale University School of Medicine, New Haven, Connecticut, 
      USA.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20220329
PL  - England
TA  - BMJ Case Rep
JT  - BMJ case reports
JID - 101526291
RN  - 8VZV102JFY (Fluconazole)
RN  - D83282DT06 (Flucytosine)
SB  - IM
MH  - *Cryptococcosis/complications/diagnosis/drug therapy
MH  - *Cryptococcus neoformans
MH  - Fluconazole/therapeutic use
MH  - Flucytosine
MH  - Humans
MH  - *Immune Reconstitution Inflammatory Syndrome/complications
PMC - PMC8966528
OTO - NOTNLM
OT  - Cryptococcus
OT  - Immunology
OT  - Infectious diseases
OT  - Medical management
COIS- Competing interests: MSV was the former PI for Connecticut AIDS Education and 
      Training Center. There are no other competing interests.
EDAT- 2022/03/31 06:00
MHDA- 2022/04/01 06:00
PMCR- 2024/03/29
CRDT- 2022/03/30 05:40
PHST- 2022/03/30 05:40 [entrez]
PHST- 2022/03/31 06:00 [pubmed]
PHST- 2022/04/01 06:00 [medline]
PHST- 2024/03/29 00:00 [pmc-release]
AID - 15/3/e247495 [pii]
AID - bcr-2021-247495 [pii]
AID - 10.1136/bcr-2021-247495 [doi]
PST - epublish
SO  - BMJ Case Rep. 2022 Mar 29;15(3):e247495. doi: 10.1136/bcr-2021-247495.