PMID- 35352222
OWN - NLM
STAT- MEDLINE
DCOM- 20220825
LR  - 20220825
IS  - 1614-7499 (Electronic)
IS  - 0944-1344 (Linking)
VI  - 29
IP  - 38
DP  - 2022 Aug
TI  - Exposure to phthalates in early pregnancy and the risk of fetal growth 
      restriction: a nested case-control study in a Zhuang Chinese population.
PG  - 57318-57329
LID - 10.1007/s11356-022-19919-z [doi]
AB  - Phthalates (PAEs) are common endocrine disrupting chemicals (EDCs) that disrupt 
      fetal development. The present study aimed to evaluate the effects of single and 
      coexposure to phthalates in early pregnancy on fetal growth restriction (FGR) by 
      a nested case-control study based on the Guangxi Zhuang Birth Cohort (GZBC). 
      Maternal serum concentrations of seven phthalates in 97 neonates with FGR and 291 
      matched controls were detected through gas chromatography-mass spectrometry 
      (GC-MS). The associations between phthalates and FGR were analyzed using multiple 
      logistic regression, weight quantile sum (WQS) regression, and Bayesian kernel 
      machine regression (BKMR) models. We found that exposures to butyl-benzyl 
      phthalate (BBP, OR(adj) = 1.849, 95% CI: 1.080-3.177, P(adj) = 0.025, 
      P(trend) = 0.046), di (2-ethyl-hexyl) phthalate (DEHP, OR(adj) = 3.893, 95% CI: 
      1.305-11.910, P(adj) = 0.015, P(trend) = 0.098) and dimethyl phthalate (DMP, 
      OR(adj) = 1.722, 95% CI: 1.089-2.725, P(adj) = 0.020, P(trend) = 0.002) were 
      significantly positively associated with the risk of FGR, while mono-butyl 
      phthalate (MBP) showed a significant negative association with FGR 
      (OR(high) = 0.192, 95% CI: 0.036-0.795, P(adj) = 0.033, P(trend) = 0.035) only 
      among girls. The WQS model identified that BBP, di(2-ethyl)phthalate (DEP), DMP, 
      DEHP, di-n-butyl phthalate (DBP), and MBP were highly weighted in the association 
      with FGR. The BKMR model supported the positive association between joint 
      exposure to phthalates and the risk of FGR and identified no significant 
      interaction between the seven phthalates. Overall, maternal exposure to BBP, 
      DEHP, and DMP may cause adverse effects on FGR, especially with combined effects.
CI  - (c) 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Guo, Xiaojing
AU  - Guo X
AD  - Department of Epidemiology and Health Statistics, School of Public Health, 
      Guangxi Medical University, Nanning, Guangxi, China.
FAU - Sheng, Yonghong
AU  - Sheng Y
AD  - Department of Teaching and Research, School of Public Health, Guangxi Medical 
      University, Nanning, Guangxi, China.
FAU - Liu, Bihu
AU  - Liu B
AD  - Department of Epidemiology and Health Statistics, School of Public Health, 
      Guangxi Medical University, Nanning, Guangxi, China.
FAU - Tang, Peng
AU  - Tang P
AD  - Department of Epidemiology and Health Statistics, School of Public Health, 
      Guangxi Medical University, Nanning, Guangxi, China.
FAU - Liu, Runfeng
AU  - Liu R
AD  - Department of Epidemiology and Health Statistics, School of Public Health, 
      Guangxi Medical University, Nanning, Guangxi, China.
FAU - Wu, Li
AU  - Wu L
AD  - Department of Epidemiology and Health Statistics, School of Public Health, 
      Guangxi Medical University, Nanning, Guangxi, China.
FAU - Chen, Jiehua
AU  - Chen J
AD  - Department of Microbiology, School of Basic Medicine, Guangxi Medical University, 
      Nanning, Guangxi, China.
FAU - Huang, Dongping
AU  - Huang D
AD  - Department of Sanitary Chemistry, School of Public Health, Guangxi Medical 
      University, Nanning, Guangxi, China.
FAU - Liu, Shun
AU  - Liu S
AD  - Department of Maternal, Child and Adolescent Health, School of Public Health, 
      Guangxi Medical University, Nanning, Guangxi, China.
FAU - Qiu, Xiaoqiang
AU  - Qiu X
AUID- ORCID: 0000-0001-9881-3664
AD  - Department of Epidemiology and Health Statistics, School of Public Health, 
      Guangxi Medical University, Nanning, Guangxi, China. xqqiu9999@163.com.
LA  - eng
GR  - AB17195012/the Guangxi Key Research Program/
GR  - 81860587/National Natural Science Foundation of China/
PT  - Journal Article
DEP - 20220329
PL  - Germany
TA  - Environ Sci Pollut Res Int
JT  - Environmental science and pollution research international
JID - 9441769
RN  - 0 (Phthalic Acids)
RN  - 2286E5R2KE (Dibutyl Phthalate)
RN  - 6O7F7IX66E (phthalic acid)
RN  - C42K0PH13C (Diethylhexyl Phthalate)
SB  - IM
MH  - Bayes Theorem
MH  - Case-Control Studies
MH  - China
MH  - Dibutyl Phthalate
MH  - *Diethylhexyl Phthalate
MH  - Female
MH  - Fetal Growth Retardation/chemically induced/epidemiology
MH  - Humans
MH  - Infant, Newborn
MH  - *Phthalic Acids/analysis
MH  - Pregnancy
OTO - NOTNLM
OT  - Coexposure
OT  - Endocrine disrupting chemicals
OT  - Fetal growth restriction
OT  - Nested case-control study
OT  - Phthalates
EDAT- 2022/03/31 06:00
MHDA- 2022/08/26 06:00
CRDT- 2022/03/30 05:43
PHST- 2021/12/07 00:00 [received]
PHST- 2022/03/22 00:00 [accepted]
PHST- 2022/03/31 06:00 [pubmed]
PHST- 2022/08/26 06:00 [medline]
PHST- 2022/03/30 05:43 [entrez]
AID - 10.1007/s11356-022-19919-z [pii]
AID - 10.1007/s11356-022-19919-z [doi]
PST - ppublish
SO  - Environ Sci Pollut Res Int. 2022 Aug;29(38):57318-57329. doi: 
      10.1007/s11356-022-19919-z. Epub 2022 Mar 29.